Results 31 to 40 of about 13,142 (173)
Memorias do Instituto Oswaldo Cruz, 1992 Different patterns of cutaneous leishmaniasis can be induced when a challenge of alike dose of Leishmania amazonensis amastigotes in various inbred strains was applied.
Kátia da Silva Calabrese +1 more
doaj +1 more source
Metabolic Adaptations of Three Inbred Strains of Mice (C57BL/6, DBA/2, and 129T2) in Response to a High-Fat Diet [PDF]
The Journal of Nutrition, 2004 Although it is now becoming more evident that the strain of mouse used to generate genetically modified models for the study of endocrine disorders contributes to the ensuing phenotype, metabolic characterization of these common strains used to produce genetically altered mice has been limited.
Alexandra, Funkat +4 more
openaire +2 more sources
British Journal of Haematology, EarlyView.Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
Frontiers in Microbiology, 2016 Tuberculosis is caused by Mycobacterium tuberculosis (M. tuberculosis, Mtb) infection, and it remains major life-threatening infectious diseases worldwide. Although Mtb has infected one-third of the present human population, only 5-10% of immunocompetent
Hyo-Ji eLee +2 more
doaj +1 more source
Physiological Genomics, 2010 To confirm seizure susceptibility (SZS) quantitative trait loci (QTLs) on chromosome (chr) 15 identified previously using C57BL/6J (B6) and DBA/2J (D2) mice and to refine their genomic map position, we studied a set of three congenic strains in which overlapping segments of chr 15 from D2 were transferred onto the B6 background.
T N, Ferraro +8 more
openaire +3 more sources
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Immobilization induced osteopenia is strain specific in mice
Bone Reports, 2015 Immobilization causes rapid and massive bone loss. By comparing Botulinum Toxin A (BTX)-induced bone loss in mouse strains with different genetic backgrounds we investigated whether the genetic background had an influence on the severity of the ...
Andreas Lodberg +5 more
doaj +1 more source
Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures
Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.This study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Markos Michail Chatzigiannis +2 more
wiley +1 more source
Journal of Lipid Research, 1995 A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk +5 more
doaj +1 more source
Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice
Scientific Reports, 2023 The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo +4 more
doaj +1 more source