Results 11 to 20 of about 13,142 (173)
Frontiers in Cell and Developmental Biology, 2022 Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice.
Juan-Felipe Perez-Correa +6 more
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DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. [PDF]
PLoS ONE, 2015 Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction.
Harriet M Jackson +8 more
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Frontiers in Behavioral Neuroscience, 2020 Sensation seeking is a heritable trait that is genetically correlated with substance use; the shared genetic mechanisms underlying these traits are largely unknown.
Price E. Dickson, Guy Mittleman
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Host genetic background strongly influences the response to influenza a virus infections. [PDF]
PLoS ONE, 2009 The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the ...
Barkha Srivastava +7 more
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Genetic analysis of intestinal cholesterol absorption in inbred mice
Journal of Lipid Research, 2001 A genetic mapping strategy was employed to identify chromosomal regions harboring genes that influence the absorption of intestinal cholesterol in the mouse.
Margrit Schwarz +3 more
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Frontiers in Pharmacology, 2018 Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-
Cheryl Reed +8 more
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Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice, [PDF]
Journal of Lipid Research, 2003 To investigate genetic contributions to individual variations of lipoprotein cholesterol concentrations, we performed quantitative trait locus/loci (QTL) analyses of an intercross of CAST/Ei and DBA/2J inbred mouse strains after feeding a high-cholesterol cholic acid diet for 10 weeks. In total, we identified four QTL for HDL cholesterol.
Lyons, M A +6 more
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Virology Journal, 2012 Background The mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly
Dengler Leonie +4 more
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Foster dams rear fighters: strain-specific effects of within-strain fostering on aggressive behavior in male mice. [PDF]
PLoS ONE, 2013 It is well known that genes and environment interact to produce behavioral phenotypes. One environmental factor with long-term effects on gene transcription and behavior is maternal care.
Kimberly H Cox +2 more
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Genes, Brain and Behavior, 2023 AbstractNicotine is the reinforcing ingredient in tobacco. Following chronic exposure, sudden cessation of nicotine use produces negative symptoms of withdrawal that contribute to dependence. The molecular mechanisms underlying nicotine withdrawal behaviors, however, are poorly understood.
Maren L. Smith +5 more
openaire +2 more sources