Results 41 to 50 of about 13,142 (173)

Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL/6J and DBA/2J Mice Using Magnetic Resonance Imaging

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
C57BL/6J and DBA/2J mice were used to investigate strain and sex‐specific features of the brain connectome in awake animals using magnetic resonance imaging (MRI). By combining resting‐state and diffusion MRI, we found significant differences in the motor, sensory, limbic, and salience networks between C57BL/6J and DBA/2J mice.
Tanzil M. Arefin, Hayreddin Said Ünsal, Thomas Neuberger, Nanyin Zhang, Helen M. Kamens   +4 more
wiley   +1 more source

Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains

Fluids and Barriers of the CNS, 2021
Background Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants.
Johanna Schaffenrath, Sheng-Fu Huang, Tania Wyss, Mauro Delorenzi, Annika Keller   +4 more
doaj   +1 more source

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta‐Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Understanding the congruent effects of different types of antidepressant treatments on sensitive brain regions, such as the hippocampus and cortex, can highlight essential mechanisms of action. We used a systematic meta‐analysis of public transcriptional profiling datasets to identify genes and functional gene sets that are differentially expressed ...
Eva M. Geoghegan, Megan H. Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I. Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra’eed Bhuiyan, Sophie Mensch, Stanley J. Watson Jr., Huda Akil, René Hen   +11 more
wiley   +1 more source

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS Genetics, 2012
Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by prolongation of the PR interval on the surface electrocardiogram (ECG). Prolongation of the PR interval is
Elisabeth M Lodder, Brendon P Scicluna, Annalisa Milano, Albert Y Sun, Hao Tang, Carol Ann Remme, Perry D Moerland, Michael W T Tanck, Geoffrey S Pitt, Douglas A Marchuk, Connie R Bezzina   +10 more
doaj   +1 more source

Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

BMC Neuroscience, 2007
Background Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression.
Schlamp Cassandra L, Semaan Sheila J, Li Yan, Nickells Robert W   +3 more
doaj   +1 more source

Conjoined Parasitic Twins (Cephalo‐Thoracopagus Parasiticus) in a Free Ranging Northern Bat (Eptesicus nilssonii): A Micro‐CT Anatomic and Genetic Survey

Anatomia, Histologia, Embryologia, Volume 55, Issue 2, March 2026.
ABSTRACT The detailed anatomical situation of male stillborn cephalo‐thoracopagus twins in a wild ranging northern bat (Eptesicus nilssonii) is described by means of full body micro‐CT scans in high resolution with three‐dimensional computational reconstruction.
J. Meyer, V. N. Laine, J. van der Kooij, B. Richter, S. Handschuh, M. Gumpenberger   +5 more
wiley   +1 more source

Reactions to spatial and nonspatial change in two inbred strains of mice: Further evidence supporting the hippocampal dysfunction hypothesis in the DBA/2 strain [PDF]

Psychobiology, 1995
Mice belonging to the inbred C57BL/6 and DBA/2 strains were repeatedly exposed to a given spatial configuration of five objects contained in an open field. Locomotor activity, habituation of exploration, and reactivity to the displacement of some objects (spatial change) and to the substitution of a familiar object by a new one (nonspatial change) were
Ammassari Teul M, Tozzi, Alessandro, Rossi Arnaud C, Save E, Thinus Blanc C.   +4 more
openaire   +3 more sources

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 [PDF]

Genes & Immunity, 2003
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that ...
H-C, Hsu, H-G, Zhang, L, Li, N, Yi, P-A, Yang, Q, Wu, J, Zhou, S, Sun, X, Xu, X, Yang, L, Lu, G, Van Zant, R W, Williams, D B, Allison, J D, Mountz   +14 more
openaire   +2 more sources

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source