Results 61 to 70 of about 1,160,575 (212)

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source

Efficient Derivation and Transcriptional Characterization of Mouse Extra‐Embryonic Endoderm Stem Cell Lines Generated by Somatic Cell Nuclear Transfer

Stem Cells International, Volume 2026, Issue 1, 2026.
Somatic cell nuclear transfer (SCNT) holds great promise for regenerative medicine and agriculture, but its application is severely hampered by low efficiency, primarily attributable to aberrant epigenetic reprogramming. Although embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) have been successfully derived from cloned embryos, an in ...
Shuaipeng Li, Shu Wei, Guomeng Li, Mei Hu, Jiangwei Lin, Wandong Bao, Satabdi Datta Choudhury   +6 more
wiley   +1 more source

Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 [PDF]

Genes & Immunity, 2003
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that ...
H-C, Hsu, H-G, Zhang, L, Li, N, Yi, P-A, Yang, Q, Wu, J, Zhou, S, Sun, X, Xu, X, Yang, L, Lu, G, Van Zant, R W, Williams, D B, Allison, J D, Mountz   +14 more
openaire   +2 more sources

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

Bone Research
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally acquired and associated with RA susceptibility.
Hongzhen Chen, Xuekun Fu, Xiaohao Wu, Junyi Zhao, Fang Qiu, Zhenghong Wang, Zhuqian Wang, Xinxin Chen, Duoli Xie, Jie Huang, Junyu Fan, Xu Yang, Yi Song, Jie Li, Dongyi He, Guozhi Xiao, Aiping Lu, Chao Liang   +17 more
doaj   +1 more source

Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.

PLoS ONE, 2013
This study builds on the findings that physical activity, such as wheel running in mice, enhances cell proliferation and neurogenesis in the adult hippocampus of the common mouse strain C57BL/6, and that the baseline level of neurogenesis varies by ...
Rupert W Overall, Tara L Walker, Odette Leiter, Sina Lenke, Susann Ruhwald, Gerd Kempermann   +5 more
doaj   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, Volume 66, Issue 12, Page 4983-4995, December 2025.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Mouse development - From oocyte to stem cells

European Journal of Histochemistry, 2014
This is a really good book for those who love developmental biology: young fellows at the beginning of their careers, esteemed professors, historians of science or fully active leading researchers.
Manuela Monti
doaj   +1 more source

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism‐related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Our previous work established the AD‐BXD mouse panel as an innovative model for studying the genetic complexity and heterogeneity underlying Alzheimer's disease (AD). In this study, we leveraged this model and proteomics approach to identify protein signatures linked to cognitive resilience in AD.
Yu Chen, Tamara K. Stevenson, Yiding Cao, Lauren A. Fish, Julia E. Robbins, Gennifer E. Merrihew, Jea Park, Timothy J. Hohman, Michael J. MacCoss, Catherine C. Kaczorowski   +9 more
wiley   +1 more source

Technetium-99m pyrophosphate uptake in spontaneously occurring perimyocardial lesions in an inbred strain of DBA/2 mice.

Japanese Circulation Journal, 1982
The spontaneous occurrence of perimyocardial calcification localized in the right ventricle has been reported in an inbred strain of DBA/2 mice. In this paper we examined the correlation between the myocardial uptake ratio of technetium-99m pyrophosphate (99mTc-PYP) and pathological findings in these mice ranging in age from one to 12 months and became
YOSHIDA, AKIRA, MATSUMORI, AKIRA, KAWAI, CHUICHI, TORIZUKA, KANJI   +3 more
openaire   +3 more sources

Quantitative Trait Loci Analysis of Structural and Material Skeletal Phenotypes in C57BL/6J and DBA/2 Second-Generation and Recombinant Inbred Mice [PDF]

Journal of Bone and Mineral Research, 2005
Abstract QTL analyses identified several chromosomal regions influencing skeletal phenotypes of the femur and tibia in BXD F2 and BXD RI populations of mice. QTLs for skeletal traits co-located with each other and with correlated traits such as body weight and length, adipose mass, and serum alkaline phosphatase ...
Lang, Dean H., Sharkey, Neil A., Mack, Holly A. (R18996), Vogler, George P., Vandenbergh, David J., Blizard, David A., Stout, Joseph T., McClearn, Gerald E.   +7 more
openaire   +3 more sources