Results 61 to 70 of about 13,142 (173)

In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain

Scientific Reports, 2017
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer.
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J. Okano, Hideyuki Okano   +5 more
doaj   +1 more source

Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains. [PDF]

PLoS ONE, 2011
The mouse has emerged as a uniquely valuable species for studying the molecular and genetic basis of complex behaviors and modeling neuropsychiatric disease states.
Lauren Lederle, Susanna Weber, Tara Wright, Michael Feyder, Jonathan L Brigman, Hans S Crombag, Lisa M Saksida, Timothy J Bussey, Andrew Holmes   +8 more
doaj   +1 more source

Enhancing sudden unexpected death in epilepsy (SUDEP) research through development of common data elements

Epilepsia Open, Volume 10, Issue 5, Page 1426-1438, October 2025.
Abstract Objective Sudden Unexpected Death in Epilepsy (SUDEP) is a fatal complication for individuals living with epilepsy and is associated with significant personal and public burden. While certain neurotransmitters and neuronal pathways have been associated with SUDEP, the exact biological mechanisms are unknown.
Sloka S. Iyengar, Elaine K. O'Loughlin, Lauren Harte‐Hargrove, Mary Holmay, Laura S. Lubbers, CURE Epilepsy SUDEP Data Standardization Project Steering Committee, CURE Epilepsy SUDEP Data Standardization Project Working Group Members, Lisa M. Bateman, Edward Glasscock, Samden Lhatoo, Philippe Ryvlin, Kristina Simeone, Charles Akos Szabo, Melanie Whittamore‐Mantzios, David Auerbach, Gordon Buchanan, Jeffrey Buchhalter, Beate Diehl, Elizabeth Donner, Carl Faingold, Daniel Friedman, Christina Gross, Bin Gu, Franck Kalume, David Ryan King, Nuria Lecumberri, Susanne Mueller, William Nobis, Jeffrey Noebels, Terence O’Brien, Manoj Patel, George Richerson, Steven Schachter, Timothy Simeone, Ian Wenker   +34 more
wiley   +1 more source

Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER

Physiological Reports, Volume 13, Issue 19, October 2025.
Study and results overview. Abstract Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain‐specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory ...
N. Amiri, H. Zhang, R. McMillan, R. W. Grange, J. C. Drake   +4 more
wiley   +1 more source

Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment

Frontiers in Behavioral Neuroscience, 2014
Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in ...
Natalia eKulesskaya, Nina N Karpova, Li eMa, Li eTian, Vootele eVoikar   +4 more
doaj   +1 more source

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, Volume 10, Issue S1, Page S40-S52, August 2025.
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.
Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley   +1 more source

MYH6‐Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2‐mdx Mice

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
D2.B10‐Dmdmdx/J dystrophic mice were crossed with Tg(myh6‐cre)1Jmk/J mice to create a cardiac‐specific Myh6‐cre (Cre+) promoter region on the D2‐mdx background. Cre+ dystrophic animals demonstrate worse right and left ventricular systolic function, which correlates with increased cardiac‐specific fibrosis and ultimately reduced survival.
India K. Hawkins, Trung Phi, Joshua Mitchell, Frank Corwin, Adolfo G. Mauro, Fadi N. Salloum, Frank J. Raucci Jr.   +6 more
wiley   +1 more source

Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?

Frontiers in Psychiatry
Under conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed, Cheryl Reed, Tamara J. Phillips, Tamara J. Phillips, Tamara J. Phillips   +4 more
doaj   +1 more source

Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds.

PLoS ONE, 2017
Quantitative trait locus (QTL) analyses of intercross populations between widely used mouse inbred strains provide a powerful approach for uncovering genetic factors that influence susceptibility to atherosclerosis.
Natalia Makhanova, Andrew P Morgan, Yukako Kayashima, Andrei Makhanov, Sylvia Hiller, Svetlana Zhilicheva, Longquan Xu, Fernando Pardo-Manuel de Villena, Nobuyo Maeda   +8 more
doaj   +1 more source