Results 71 to 80 of about 1,442,388 (221)

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity-2

, 2011
Copyright information:Taken from "Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity"BMC Neuroscience 2005;6():18-18.Published online 17 Mar 2005PMCID:PMC1079866.Copyright © 2005 Airey et al; licensee BioMed ...
Katherine M Enzinger (71411), David C Airey (65999), Alicia I Robbins (71410), Christine E Collins (66002), Fangbai Wu (66000)   +4 more
core   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Dual Host–Pathogen Screening of the Lung During Severe Influenza Using Spatial Transcriptomics

Immunology &Cell Biology, EarlyView.
We performed genome‐wide spatial transcriptomics at 10 μm resolution on the lungs of mice infected with influenza A virus. We utilised publicly available scRNAseq reference datasets to identify cell types present. We found viral transcripts across all detected cell types, suggesting localised indiscriminate infection.
Marcus Z. W. Tong, Oliver P. Skinner, Chen Zhu, Brooke J. Wanrooy, Ashlyn S. Kerr, Zheng Ruan, Cameron G. Williams, Heran Zhang, Linda M. Wakim, Ashraful Haque   +9 more
wiley   +1 more source

The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

Reproductive Biology and Endocrinology, 2007
Background A major event in the post-meiotic development of male germ cells is the formation of the acrosome. This process can be perturbed in C57BL/6 mice by administration of the small molecule miglustat (N-butyldeoxynojirimycin, NB-DNJ). The miglustat-
Boomkamp Stephanie, Gottwald Ulrich, Leifke Eckhard, Fritsch Martin, Voigtmann Ulrike, Walden Charlotte M, Bone Wilhelm, Platt Frances M, van der Spoel Aarnoud C   +8 more
doaj   +1 more source

Superovulation using the combined administration of inhibin antiserum and equine chorionic gonadotropin increases the number of ovulated oocytes in C57BL/6 female mice. [PDF]

PLoS ONE, 2015
Superovulation is a reproductive technique generally used to produce genetically engineered mice. Superovulation in mice involves the administration of equine chorionic gonadotropin (eCG) to promote follicle growth and then that of human chorionic ...
Toru Takeo, Naomi Nakagata
doaj   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping

Frontiers in Genetics, 2019
The interfrontal bone (IF) is a minor skeletal trait residing between the frontal bones. IF is considered a quasi-continuous trait. Genetic and environmental factors appear to play roles in its development. The mechanism(s) underlying IF bone development
Heather Zimmerman, Zhaoyu Yin, Fei Zou, Eric T. Everett, Eric T. Everett   +4 more
doaj   +1 more source

Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis [PDF]

Cellular Microbiology, 2019
Individual susceptibility differences to fungal infection following invasive and/or immunosuppressive medical interventions are an important clinical issue. In order to explore immune response-related factors that may be linked to fungal infection susceptibility, we have compared the response of inbred C57BL/6J and outbred CD1 mouse strains to ...
Esther Carreras, María Velasco de Andrés, Marc Orta‐Mascaró, Inês T. Simões, Cristina Català, Oscar Zaragoza, Francisco Lozano   +6 more
openaire   +2 more sources