Results 81 to 90 of about 209,389 (213)

Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 Mice

, 2020
Development of medical countermeasures against radiation relies on robust animal models for efficacy testing. Mouse models have advantages over larger species due to economics, ease of conducting aging studies, existence of historical databases, and ...
Barry P. Katz, Miller, Steve J., Sampson, Carol H., Feng, Hailin, Hailin Feng, Unthank, Joseph L., Steven J. Miller, Alexa Fisher, Hui Lin Chua, Patterson, Andrea M., Katz, Barry P., Andrea M. Patterson, Carol H. Sampson, Fisher, Alexa, MacVittie, Thomas J., Plett, P. Artur, Orschell, Christie M., P. Artur Plett, Joseph L. Unthank, Christie M. Orschell, Thomas J. MacVittie, Chua, Hui Lin   +21 more
core   +1 more source

The Inflammatory Response in the Murine Ovalbumin‐Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Ida Wang Henriksen, Christina Bartholdy, Janne Koch, Denitsa Vladimirova Stefanova, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen   +5 more
wiley   +1 more source

Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice

Journal of Lipid Research, 1993
Compared to BALB/c mice, inbred C57BL/6 mice are more susceptible to developing fatty streak atherosclerotic lesions when fed a cholesterol-rich diet containing taurocholate. We examined the metabolic basis for the taurocholate requirement.
S Dueland, J Drisko, L Graf, D Machleder, AJ Lusis, RA Davis   +5 more
doaj   +1 more source

Mitochondrial‐Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC‐HETB/W Rat

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia‐Jaramillo, Nagib Ahsan, Janet C. Siebert, Sarah J. Borengasser, Norman G. Hord, Michael B. Stout, Steven Austad, Arlan Richardson   +13 more
wiley   +1 more source

Development of a syngeneic mouse model of epithelial ovarian cancer

Journal of Ovarian Research, 2010
Background Most cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity.
Quinn Bridget A, Xiao Fang, Bickel Laura, Martin Lainie, Hua Xiang, Klein-Szanto Andres, Connolly Denise C   +6 more
doaj   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, Volume 13, Issue 28, 18 May 2026.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency [PDF]

, 2005
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria.
Lamb, Tracey J, Andrea L. Graham, Tracey J. Lamb, Andrew F. Read, A Andrew F. Read, Judith E. Allen, Graham, Andrea L, Read, Andrew F, Allen, Judith E   +8 more
core   +1 more source

sj-pdf-1-lan-10.1177_00236772221138942 - Supplemental material for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice

, 2023
Supplemental material, sj-pdf-1-lan-10.1177_00236772221138942 for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice by Davide De Biase, Teresa Bruna Pagano, Donatella Malanga, Valeria Russo, Giuseppe ...
Serenella Papparella (849204), Orlando Paciello (296217), Valentina Iovane (6077066), Marzia Scarfò (269240), Davide De Biase (4806198), Valeria Russo (365364), Giuseppe Piegari (8097332), Teresa Bruna Pagano (8097329), Ilaria d’Aquino (14342356), Donatella Malanga (184157), Slawomir Wojcik (14342359)   +10 more
core   +1 more source

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity-2

, 2011
Copyright information:Taken from "Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity"BMC Neuroscience 2005;6():18-18.Published online 17 Mar 2005PMCID:PMC1079866.Copyright © 2005 Airey et al; licensee BioMed ...
Katherine M Enzinger (71411), David C Airey (65999), Alicia I Robbins (71410), Christine E Collins (66002), Fangbai Wu (66000)   +4 more
core   +1 more source

sj-pdf-2-lan-10.1177_00236772221138942 - Supplemental material for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice

, 2023
Supplemental material, sj-pdf-2-lan-10.1177_00236772221138942 for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice by Davide De Biase, Teresa Bruna Pagano, Donatella Malanga, Valeria Russo, Giuseppe ...
Serenella Papparella (849204), Orlando Paciello (296217), Valentina Iovane (6077066), Marzia Scarfò (269240), Davide De Biase (4806198), Valeria Russo (365364), Giuseppe Piegari (8097332), Teresa Bruna Pagano (8097329), Ilaria d’Aquino (14342356), Donatella Malanga (184157), Slawomir Wojcik (14342359)   +10 more
core   +1 more source