Results 91 to 100 of about 1,340,693 (219)

Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice

Journal of Lipid Research, 1993
Compared to BALB/c mice, inbred C57BL/6 mice are more susceptible to developing fatty streak atherosclerotic lesions when fed a cholesterol-rich diet containing taurocholate. We examined the metabolic basis for the taurocholate requirement.
S Dueland, J Drisko, L Graf, D Machleder, AJ Lusis, RA Davis   +5 more
doaj   +1 more source

Consistent individual differences in some behaviors in mice of the C57Bl/6J inbred strain [PDF]

Anuario de Psicología, 2016
Mice of the inbred C57Bl/6J strain displayed considerable inter-mice variation in ambulation, rearing, grooming, and defecation in the open-field (coefficients of variation from 30% to 150%). Those differences were not random, because six measurements of the same behavior, taken along six months, were correlated (Kendall coefficients of concordance were ...
openaire   +3 more sources

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

Baat‐Deficient Mice Recapitulate Elevated 7α‐Hydroxy‐3‐Oxo‐4‐Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACTBile acid Coenzyme A: amino acid N‐acyltransferase (BAAT) catalyzes the conjugation of bile acids with taurine or glycine, a process essential for bile acid solubility and intestinal lipid absorption. Mutations in BAAT cause an inborn error of bile acid metabolism, typically characterized by reduced conjugated bile acids and fat‐soluble vitamin
Soma Koga, Hajime Takei, Ryutaro Tamura, Yugo Takaki, Hiroyuki Kusuhara, Hiroshi Nittono, Hisamitsu Hayashi   +6 more
wiley   +1 more source

Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
This study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa   +2 more
wiley   +1 more source

Postnatal development of the optic nerve in (C57BL x CBA)F1 hybrid mice:general changes in morphometric parameters [PDF]

, 1996
A morphometric analysis of the optic nerve in different age groups of (C57BL x CBA)F1 hybrid mice was carried out. Morphometric parameters examined were mean nerve cross-sectional area (csa), mean myelinated nerve fibre count, mean myelinated nerve fibre
Dangata, Y Y, Findlater, G S, Kaufman, M H   +2 more
core  

The role of GABAB(1) receptor isoforms in anxiety and depression : genetic and pharmacological studies in the mouse [PDF]

, 2007
Anxiety and depression disorders represent common, serious and growing health problems world-wide. The neurobiological basis of anxiety and depression, however, remains poorly understood.
Jacobson, Laura Helen
core   +1 more source

Development of a syngeneic mouse model of epithelial ovarian cancer

Journal of Ovarian Research, 2010
Background Most cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity.
Quinn Bridget A, Xiao Fang, Bickel Laura, Martin Lainie, Hua Xiang, Klein-Szanto Andres, Connolly Denise C   +6 more
doaj   +1 more source

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity-1

, 2011
Copyright information:Taken from "Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity"BMC Neuroscience 2005;6():18-18.Published online 17 Mar 2005PMCID:PMC1079866.Copyright © 2005 Airey et al; licensee BioMed ...
Katherine M Enzinger (71411), David C Airey (65999), Alicia I Robbins (71410), Christine E Collins (66002), Fangbai Wu (66000)   +4 more
core   +1 more source

Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]

, 2006
The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
core   +1 more source