Results 111 to 120 of about 1,442,388 (221)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

Frontiers in Neuroscience
Oscillations, a highly conserved brain function across mammalian species, play a pivotal role in both brain physiology and pathology. Traumatic brain injury (TBI) frequently results in subacute and chronic alterations in brain oscillations, which are ...
Tyler Shannon, Noah Levine, Rina Dirickson, Yuyan Shen, Christopher Cotter, Christopher Cotter, Noora Rajjoub, Julie Fitzgerald, Julie Fitzgerald, Fernando Pardo-Manuel de Villena, Fernando Pardo-Manuel de Villena, Olga Kokiko-Cochran, Olga Kokiko-Cochran, Olga Kokiko-Cochran, Bin Gu, Bin Gu   +15 more
doaj   +1 more source

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

Distinct EEG Features and Sleep/Wake Behaviour Predict Anxiety Phenotypes in Mice

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Preoperative anxiety is a prevalent clinical problem linked to adverse surgical outcomes, including elevated pain, prolonged hospital stays and increased risk of postoperative delirium. Current assessments rely heavily on subjective measures, necessitating objective biomarkers.
A. Altunkaya, K. M. Mengel, M. V. Schmidt, B. Solak, M. Kreuzer, G. Rammes, G. Schneider, T. Fenzl   +7 more
wiley   +1 more source

Differences in the Flexibility of Switching Learning Strategies and CREB Phosphorylation Levels in Prefrontal Cortex, Dorsal Striatum, and Hippocampus in Two Inbred Strains of Mice

Frontiers in Behavioral Neuroscience, 2016
Flexibility in using different learning strategies was assessed in two different inbred strains of mice, the C57BL/6 and DBA/2 strains. Mice were trained sequentially in two different Morris water maze protocols that tested their ability to switch their ...
Woo-Hyun Cho, Jung-Soo Han
doaj   +1 more source

Haploinsufficiency of the Tyrosine Hydroxylase Gene in the Inbred C57BL/6J Strain Alters Behavior, Immunity, and Oxidative Stress, Especially After Acute Stress

Catecholamines (CA) are considered to play key roles in acute stress responses, but they also regulate important functions of the nervous, immune, and endocrine systems and are essential for body homeostasis and health.
Fuente Del Rey, María Mónica De La, De la Fuente, M\uf3nica, Mónica De la Fuente, Garrido, Antonio, F\ue9lix, Judith, Antonio Garrido, Judith Félix, Félix Escalera, Judith   +7 more
core   +1 more source

Vaccination With Trichuris muris Poly‐Cysteine and Histidine‐Tailed Protein p43 Protects Against Chronic Infection

Parasite Immunology, Volume 48, Issue 10, October 2026.
ABSTRACT Trichuris trichiura is one of the soil transmitted geohelminths which together currently affect approximately 25% of the global population resulting in considerable morbidity particularly in children and young adults. Recent estimates put infection by T. trichiura at approximately 513 million.
Allison J. Bancroft, Kelly S. Hayes, Laura Campbell, Seona Thompson, Christina Dold, Luke Blackwell, Christine S. Rollier, David J. Thornton, Richard K. Grencis   +8 more
wiley   +1 more source

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants[S]

Journal of Lipid Research, 2018
Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with ...
Jessica M. Lee, Jessica R. Ong, Laurent Vergnes, Thomas Q. de Aguiar Vallim, Jonathan Nolan, Rita M. Cantor, JulianR.F. Walters, Karen Reue   +7 more
doaj   +1 more source

Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production [PDF]

, 2005
It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females.
Bastian Pasche, Helmut Fuchs, Andreas Lengeling, Hrabě de Angelis, M., Franz, T.J., Busch, D.H., Tobias J. Franz, Pasche, B., Busch, Dirk H, Busch, Dirk H., Kalaydjiev, S., Kremmer, E., Valérie Gailus-Durner, Martin Hrabé de Angelis, Kremmer, Elisabeth, Franz, Tobias J., De Angelis, Martin Hrabé, Pasche, Bastian, Dirk H. Busch, Lengeling, A., Fuchs, H., Fuchs, Helmut, Kalaydjiev, Svetoslav, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lengeling, Andreas, Svetoslav Kalaydjiev, Gailus-Durner, V., Franz, Tobias J, Elisabeth Kremmer, Pasche, B;Kalaydjiev, S;Franz, TJ;Kremmer, E;Gailus-Durner, V;Fuchs, H;Hrabé de Angelis, M;Lengeling, A;Busch, DH, Pasche, B. ; Kalaydjiev, S. ; Franz, T.J. ; Kremmer, E. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabé de Angelis, M. ; Lengeling, A. ; Busch, D.H.   +31 more
core   +1 more source