Results 1 to 10 of about 3,039,643 (308)

Mouse MRI shows brain areas relatively larger in males emerge before those larger in females

Nature Communications, 2018
Sex differences occur in various aspects of neurodevelopment. Here the authors use manganese-enhanced MRI at nine different postnatal stages to detail the development of structural sex differences in the mouse brain.
Lily R. Qiu, Darren J. Fernandes, Kamila U. Szulc-Lerch, Jun Dazai, Brian J. Nieman, Daniel H. Turnbull, Jane A. Foster, Mark R. Palmert, Jason P. Lerch   +8 more
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Selective breeding and selection mapping using a novel wild-derived heterogeneous stock of mice revealed two closely-linked loci for tameness

Scientific Reports, 2017
Tameness is a major behavioral factor for domestication, and can be divided into two potential components: motivation to approach humans (active tameness) and reluctance to avoid humans (passive tameness).
Yuki Matsumoto, Tatsuhiko Goto, Jo Nishino, Hirofumi Nakaoka, Akira Tanave, Toshiyuki Takano-Shimizu, Richard F. Mott, Tsuyoshi Koide   +7 more
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Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant

Cell Death and Disease, 2023
Pathogenic variants in BRCA2 are known to significantly increase the lifetime risk of developing breast and ovarian cancers. Sequencing-based genetic testing has resulted in the identification of thousands of BRCA2 variants that are considered to be ...
Arun Prakash Mishra, Suzanne Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K. Martin, Mary Albaugh, Eileen Southon, Sandra Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K. Sharan   +15 more
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Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging

Molecular Autism, 2018
Background The serotonin (5-HT) system has long been implicated in autism spectrum disorder (ASD) as indicated by elevated whole blood and platelet 5-HT, altered platelet and brain receptor and transporter binding, and genetic linkage and association ...
Jacob Ellegood, Yohan Yee, Travis M. Kerr, Christopher L. Muller, Randy D. Blakely, R. Mark Henkelman, Jeremy Veenstra-VanderWeele, Jason P. Lerch   +7 more
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X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes

Nature Communications
The lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest ...
Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen   +25 more
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Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

Scientific Reports, 2017
Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice.
Yasuyuki Horii, Tatsuhiro Nagasawa, Hiroyuki Sakakibara, Aki Takahashi, Akira Tanave, Yuki Matsumoto, Hiromichi Nagayama, Kazuto Yoshimi, Michiko T. Yasuda, Kayoko Shimoi, Tsuyoshi Koide   +10 more
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LSH mediates gene repression through macroH2A deposition

Nature Communications, 2020
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge   +8 more
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Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery

Translational Psychiatry
Major depressive disorder (MDD) is a severe psychiatric condition that significantly impacts the overall quality of life. Although MDD can occur across all age groups, it is notably prevalent among older individuals, with the aggravating circumstance ...
Giovanni Lai, Marco Malavolta, Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Tiziana Casoli, Marta Balietti   +6 more
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Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice

BMC Genomics, 2018
Background Salmonella is a Gram-negative bacterium causing a wide range of clinical syndromes ranging from typhoid fever to diarrheic disease. Non-typhoidal Salmonella (NTS) serovars infect humans and animals, causing important health burden in the world.
Jing Zhang, Danielle Malo, Richard Mott, Jean-Jacques Panthier, Xavier Montagutelli, Jean Jaubert   +5 more
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Claudin-12 is not required for blood–brain barrier tight junction function

Fluids and Barriers of the CNS, 2019
Background The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS.
Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt   +10 more
doaj   +1 more source