Results 1 to 10 of about 2,166,853 (162)
Cell, 2020 Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the complicated circuits underlying ...
Abbott, Larry F. +24 more
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Author Correction: Study of mouse behavior in different gravity environments
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Michihiko Shimomura +7 more
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Study of mouse behavior in different gravity environments
Scientific Reports, 2021 Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study,
Michihiko Shimomura +7 more
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Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring
Translational Psychiatry, 2021 Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce long-term effects in offspring. These effects include increased risk of neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), depression ...
Darren J. Fernandes +7 more
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Mouse Resource Browser--a database of mouse databases [PDF]
Database, 2010 The laboratory mouse has become the organism of choice for discovering gene function and unravelling pathogenetic mechanisms of human diseases through the application of various functional genomic approaches. The resulting deluge of data has led to the deployment of numerous online resources and the concomitant need for formalized experimental ...
Michael Zouberakis +11 more
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Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
Nature Communications, 2020 Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates ...
Gianluca Fulgenzi +11 more
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Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty
Cells, 2023 The spreading of senescent cells’ burden holds profound implications for frailty, prompting the exploration of novel therapeutic targets. In this perspective review, we delve into the intricate mechanisms underlying senescent cell spreading, its ...
Serena Marcozzi +6 more
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Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour
Scientific Reports, 2022 Protocadherin 9 (Pcdh9) is a member of the cadherin superfamily and is uniquely expressed in the vestibular and limbic systems; however, its physiological role remains unclear.
Masato Uemura +12 more
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Molecular Autism, 2017 Background Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls. The majority of RTT cases are caused by de novo mutations in methyl-CpG-binding protein 2 (MECP2), and several mouse models have been created to further ...
Rylan Allemang-Grand +6 more
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Animal Welfare, 2000 AbstractIn this paper we describe the existence and consequences of subspecific and individual variation in the genetic make-up of house mice. The purpose is to illustrate forms of variation that are often neglected in discussions about animal care and experimental design. Towards this end, different inbred mouse strains as well as genetically selected
Sluyter, F., Oortmerssen, G.A. van
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