Results 21 to 30 of about 2,175,037 (261)
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
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Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Nature Communications, 2016 The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Xia Ding +20 more
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Developmental Changes in the ECG of a Hamster Model of Muscular Dystrophy and Heart Failure
Frontiers in Pharmacology, 2012 Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The delta-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular ...
Thomas Gerard Hampton +4 more
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Cancer cell survival depends on collagen uptake into tumor-associated stroma
Nature Communications, 2022 Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu +21 more
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Disease Models & Mechanisms, 2021 In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown.
Anum Rahman +8 more
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Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI
Scientific Reports, 2022 Animal models are an indispensable platform used in various research disciplines, enabling, for example, studies of basic biological mechanisms, pathological processes and new therapeutic interventions.
Markus Kraiger +8 more
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The Journal of the American Association of Gynecologic Laparoscopists, 1999 To develop a technique for performing laparoscopy in the mouse.Controlled animal study (Canadian Task Force classification II-1).University research laboratory.Twenty-eight CD-1 pregnant mice.Eight mice underwent anesthesia only and 20 had anesthesia plus laparoscopy at 5.5 and at 10.5 days' gestation (implantation occurs on day 4.5 and delivery on ...
E, Hirsch +3 more
openaire +2 more sources
Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia
Disease Models & Mechanisms, 2019 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani +7 more
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Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source