Results 21 to 30 of about 3,039,643 (308)

BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks

Nature Communications, 2022
Mishra et al. have generated mice with a single amino acid substitution in BRCA2, which disrupts its interaction with DSS1 resulting in a severe HR defect. They show the interaction to be dispensable for HR at replication induced and meiotic DSBs.
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan   +15 more
doaj   +1 more source

Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay

Breast Cancer Research, 2020
Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance.
Nirmala Sirisena, Kajal Biswas, Teresa Sullivan, Stacey Stauffer, Linda Cleveland, Eileen Southon, Vajira H. W. Dissanayake, Shyam K. Sharan   +7 more
doaj   +1 more source

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

Brain Sciences, 2021
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova, Tiziana Orsini, Paolo Fruscoloni, Francesco Chiani, Alessia Gambadoro, Sabrina Putti, Maurizio Cirilli, Alessio Mezzi, Saulius Kaciulis, Miriam Pasquini, Marcello Raspa, Ferdinando Scavizzi, Glauco P. Tocchini-Valentini   +12 more
doaj   +1 more source

A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays

npj Genomic Medicine, 2020
Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are considered to
Kajal Biswas, Gary B. Lipton, Stacey Stauffer, Teresa Sullivan, Linda Cleveland, Eileen Southon, Susan Reid, Valentin Magidson, Edwin S. Iversen, Shyam K. Sharan   +9 more
doaj   +1 more source

Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. [PDF]

, 2001
peer reviewedBACKGROUND: The ENU Mouse Mutagenesis Project aims at a large-scale, systematic production of mouse mutants using the alkylating agent ethyl-nitrosourea (ENU).
Wolf, A., Behrendt, Heidrun, Alessandrini, Francesca, Behrend, H., Ring, J., Wolf, Alexander, Ring, Johannes, Jakob, T., Hrabe de Angelis, M., Jakob, Thilo, Alessandrini, F., BALLING, Rudi, Wolf, Eckhard, Behrendt, H., Hrabé de Angelis, Martin, Wolf, E., Balling, R., Balling, Rudolf, Alessandrini, F. ; Jakob, T. ; Wolf, A. ; Wolf, E. ; Balling, R. ; Hrabé de Angelis, M. ; Ring, J. ; Behrend, H., Alessandrini, Francesca;Jakob, Thilo;Wolf, Alexander;Wolf, Eckhard;Balling, Rudolf;de Angelis, Martin Hrabe;Ring, Johannes;Behrendt, Heidrun   +19 more
core   +1 more source

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

Nature Communications, 2018
Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.
Kajal Biswas, Subha Philip, Aditya Yadav, Betty K. Martin, Sandra Burkett, Vaibhav Singh, Anav Babbar, Susan Lynn North, Suhwan Chang, Shyam K. Sharan   +9 more
doaj   +1 more source

Pontin is essential for murine hematopoietic stem cell survival

Haematologica, 2012
Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression.
Oxana Bereshchenko, Elena Mancini, Luisa Luciani, Adriana Gambardella, Carlo Riccardi, Claus Nerlov   +5 more
doaj   +1 more source

Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease

EMBO Molecular Medicine, 2014
The recent precipitous rise in autoimmune diseases is placing an increasing clinical and economic burden on health systems worldwide. Current therapies are only moderately efficacious, often coupled with adverse side effects.
Daniel Bilbao, Luisa Luciani, Bjarki Johannesson, Agnieszka Piszczek, Nadia Rosenthal   +4 more
doaj   +1 more source

TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior

Translational Psychiatry, 2022
Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling through basal forebrain projections
Sudhirkumar Yanpallewar, Francesco Tomassoni-Ardori, Mary Ellen Palko, Zhenyi Hong, Erkan Kiris, Jodi Becker, Gianluca Fulgenzi, Lino Tessarollo   +7 more
doaj   +1 more source

Cloning expression and characterisation of the globular head regions of mouse CIQ [PDF]

, 2014
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityThe classical pathway of complement system, activated by immune complexes, involves binding of globular heads of C1q to the Fc regions of aggregated IgG or ...
Shastri, Abhishek
core   +7 more sources