Results 21 to 30 of about 2,166,952 (261)
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
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Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Nature Communications, 2016 The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Xia Ding +20 more
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Developmental Changes in the ECG of a Hamster Model of Muscular Dystrophy and Heart Failure
Frontiers in Pharmacology, 2012 Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The delta-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular ...
Thomas Gerard Hampton +4 more
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Cancer cell survival depends on collagen uptake into tumor-associated stroma
Nature Communications, 2022 Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu +21 more
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Insulin Resistance: From Mechanisms to Therapeutic Strategies [PDF]
Diabetes & Metabolism Journal, 2022 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee +2 more
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Disease Models & Mechanisms, 2021 In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown.
Anum Rahman +8 more
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Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI
Scientific Reports, 2022 Animal models are an indispensable platform used in various research disciplines, enabling, for example, studies of basic biological mechanisms, pathological processes and new therapeutic interventions.
Markus Kraiger +8 more
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Nature Communications, 2021 LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.
Xiaoping Xu +11 more
doaj +1 more source
The Journal of the American Association of Gynecologic Laparoscopists, 1999 To develop a technique for performing laparoscopy in the mouse.Controlled animal study (Canadian Task Force classification II-1).University research laboratory.Twenty-eight CD-1 pregnant mice.Eight mice underwent anesthesia only and 20 had anesthesia plus laparoscopy at 5.5 and at 10.5 days' gestation (implantation occurs on day 4.5 and delivery on ...
E, Hirsch +3 more
openaire +2 more sources