Results 31 to 40 of about 3,039,643 (308)

Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells

Scientific Reports, 2017
Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders.
Yixing Han, Jianke Ren, Eunice Lee, Xiaoping Xu, Weishi Yu, Kathrin Muegge   +5 more
doaj   +1 more source

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Polgár, Zsuzsanna, Varga, Eszter, Klincumhom, Nuttha, Dinnyés, András, Nemes, Csilla, Pirity, Melinda K.   +5 more
core   +1 more source

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Nature Communications, 2016
The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig, Shyam K. Sharan   +20 more
doaj   +1 more source

Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

Cell Reports, 2023
Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu, Ling Lin, Babul Moni Ram, Omprakash Shriwas, Kun-Han Chuang, Siyuan Dai, Kuo-Hui Su, Zijian Tang, Chengkai Dai   +8 more
doaj   +1 more source

Developmental Changes in the ECG of a Hamster Model of Muscular Dystrophy and Heart Failure

Frontiers in Pharmacology, 2012
Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The delta-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular ...
Thomas Gerard Hampton, Ajit eKale, Scott eMcCue, Hemmi eBhagavan, Case eVanDongen   +4 more
doaj   +1 more source

Mouse Trapping [PDF]

Science, 1893
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openaire   +3 more sources

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Nature Communications, 2022
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix   +21 more
doaj   +1 more source

A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow

Disease Models & Mechanisms, 2021
In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown.
Anum Rahman, Taylor DeYoung, Lindsay S. Cahill, Yohan Yee, Sarah K. Debebe, Owen Botelho, Mike Seed, Rajiv R. Chaturvedi, John G. Sled   +8 more
doaj   +1 more source

Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]

, 2003
The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J., Speicher, M. R., Klein, C. A., Klein, C.A., Jentsch, I., Speicher, M.R., Jentsch, I;Geigl, J;Klein, CA;Speicher, MR, Jentsch, I.;Geigl, J.;Klein, C. A.;Speicher, M. R.   +7 more
core   +1 more source

Enhanced gene trapping in mouse embryonic stem cells [PDF]

, 2008
Gene trapping is used to introduce insertional mutations into genes of mouse embryonic stem cells (ESCs). It is performed with gene trap vectors that simultaneously mutate and report the expression of the endogenous gene at the site of insertion and ...
Hansen, J., von Melchner, H., Ruiz Noppinger, Patricia, Wurst, W., Schnütgen, Frank, Floss, Thomas, Hansen, Jens, Horn, C., Ruiz Noppinger, P., Horn, Carsten, Lutz, M., Lutz, Marcus, Schnütgen, F., De-Zolt, Silke, De-Zolt, S., Wurst, Wolfgang, Melchner, Harald von (Prof. Dr.), Floß, T.   +17 more
core   +1 more source