Results 11 to 20 of about 2,166,952 (261)
Nature Communications, 2022 Mishra et al. have generated mice with a single amino acid substitution in BRCA2, which disrupts its interaction with DSS1 resulting in a severe HR defect. They show the interaction to be dispensable for HR at replication induced and meiotic DSBs.
Arun Prakash Mishra +15 more
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Breast Cancer Research, 2020 Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance.
Nirmala Sirisena +7 more
doaj +1 more source
npj Genomic Medicine, 2020 Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are considered to
Kajal Biswas +9 more
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Brain Sciences, 2021 Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova +12 more
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Nature Reviews Genetics, 2020 A new study in Cell describes the CRISPR array repair lineage tracing (CARLIN) engineered mouse line that genomically encodes all the components for CRISPR-based lineage tracking at single-cell resolution.
openaire +2 more sources
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
Nature Communications, 2018 Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.
Kajal Biswas +9 more
doaj +1 more source
Pontin is essential for murine hematopoietic stem cell survival
Haematologica, 2012 Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression.
Oxana Bereshchenko +5 more
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Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease
EMBO Molecular Medicine, 2014 The recent precipitous rise in autoimmune diseases is placing an increasing clinical and economic burden on health systems worldwide. Current therapies are only moderately efficacious, often coupled with adverse side effects.
Daniel Bilbao +4 more
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Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
Scientific Reports, 2017 Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders.
Yixing Han +5 more
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TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
Translational Psychiatry, 2022 Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling through basal forebrain projections
Sudhirkumar Yanpallewar +7 more
doaj +1 more source