Results 51 to 60 of about 3,039,643 (308)
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome [PDF]
, 2009 Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O’Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033–
Bliss, T. V.P. +18 more
core +1 more source
Nature Communications, 2021 LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.
Xiaoping Xu +11 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
dancebean/mouse-brain-atlas 0.2
, 2019 Mouse Brain Atlas, including templates full brain of FVB_NCrl/C57BL/6J mouse model, and atlas of cerebellum for Tc1 mouse. The most up-to-dated mouse cerebellar laminar sublayer data is available at: https://github.com/dancebean/mouse-brain-atlas/tree/0.
dancebean
core +1 more source
Efficient genome editing in wild strains of mice using the i-GONAD method
Scientific Reports, 2022 Wild mouse strains have been used for many research studies, because of the high level of inter-strain genetic and phenotypic variations in them, in addition to the characteristic phenotype maintained from wild mice.
Yuji Imai +3 more
doaj +1 more source
Biomedicines, 2021 The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal therapies should tackle the core AD pathophysiology and prevent the decline
Yi-An Chen +7 more
doaj +1 more source
Journal of Law and the Biosciences, 2015 As one of the actors in the mouse trolling drama detailed in Bubela, Vishnubhakat and Cook-Deegan (2015),1 I might say that, although I was not aware of this or contacted by the authors before publication, I am in complete agreement with their paper and its conclusions.
openaire +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source