The role of anoctamin 1 in liver disease. [PDF]
J Cell Mol MedLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC).
Li X +6 more
europepmc +4 more sources
Interaction between thermosensitive TRP channels and anoctamin 1. [PDF]
J Physiol SciSome thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ...
Takayama Y.
europepmc +4 more sources
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. [PDF]
Pflugers Arch, 2023 Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral ...
Ousingsawat J +3 more
europepmc +5 more sources
Anoctamin-1 in the juvenile rat urinary bladder. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos +2 more
doaj +6 more sources
Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity [PDF]
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +5 more sources
Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis†. [PDF]
Biol ReprodAltered peristaltic and ciliary dysfunction is a feature of females with endometriosis. To further explore this premise, we examined the ampulla of rhesus macaques (Macaca mulatta) with and without spontaneous endometriosis for the expression of ...
Luo F, Slayden O.
europepmc +4 more sources
Frontiers in Bioscience-Landmark, 2022 Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu +7 more
doaj +4 more sources
Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj +3 more sources
Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. [PDF]
FASEB J, 2019 The Ca2+‐activated Cl− channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development.
Mazzone A +8 more
europepmc +4 more sources
Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle. [PDF]
J Physiol Sci, 2021 Currently available tocolytic agents are not effective treatment for preterm labor beyond 48 h. A major reason is the development of maternal side effects which preclude the maintenance of an effective steady-state drug concentration.
Hyuga S +8 more
europepmc +2 more sources