Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders [PDF]
Frontiers in Physiology, 2023 Chloride homeostasis is critical in the physiological functions of the central nervous system (CNS). Its concentration is precisely regulated by multiple ion-transporting proteins such as chloride channels and transporters that are widely distributed in ...
Zhiyu Wang, Kaylee Choi
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Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels [PDF]
Molecules, 2023 Many transmembrane proteins are modulated by intracellular or extracellular pH. Investigation of pH dependence generally proceeds by mutagenesis of a wide set of amino acids, guided by properties such as amino-acid conservation and structure.
Kathleen Elverson +3 more
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The Role of Chloride Channels in the Multidrug Resistance [PDF]
Membranes, 2021 Nowadays, one of medicine’s main and most challenging aims is finding effective ways to treat cancer. Unfortunately, although there are numerous anti-cancerous drugs, such as cisplatin, more and more cancerous cells create drug resistance.
Bartosz Wilczyński +3 more
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The role of the Smad2/3/4 signaling pathway in osteogenic differentiation regulation by ClC-3 chloride channels in MC3T3-E1 cells [PDF]
Journal of Orthopaedic Surgery and Research, 2022 Background ClC-3 chloride channels promote osteogenic differentiation. Transforming growth factor-β1 (TGF-β1) and its receptors are closely related to ClC-3 chloride channels, and canonical TGF-β1 signaling is largely mediated by Smad proteins.
Xiaolin Lu +4 more
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Role of voltage-gated chloride channels in epilepsy: current insights and future directions [PDF]
Frontiers in PharmacologyEpilepsy is a prevalent chronic neurological disorder characterised by recurrent seizures caused by excessive neuronal discharge. Disruptions in chloride ion homeostasis significantly affect neuronal excitability, and play a crucial role in the ...
Ming-Ming Ni +4 more
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Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies? [PDF]
Pharmacology Research & PerspectivesChloride channels are involved in many cellular processes, including cell volume regulation, modulation of cell excitability, and electrolyte and water secretion.
Paola Laghetti +4 more
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Placental Chloride Channels: A Review
Placenta, 2009 The human placental syncytiotrophoblast (hSTB) is a polarized epithelial structure, that forms the main barrier to materno-fetal exchange. The chloride (Cl(-)) channels in other epithelial tissues contribute to several functions, such as maintenance of the membrane potential, volume regulation, absorption and secretion.
G Riquelme
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Chloride channels as drug targets [PDF]
Nature Reviews Drug Discovery, 2008 Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth ...
Luis Galietta +2 more
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Intracellular Chloride Channels: Novel Biomarkers in Diseases [PDF]
Frontiers in Physiology, 2020 Ion channels are integral membrane proteins present on the plasma membrane as well as intracellular membranes. In the human genome, there are more than 400 known genes encoding ion channel proteins.
Shubha Gururaja Rao +2 more
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Cardiac Electrophysiological Effects of Light-Activated Chloride Channels [PDF]
Frontiers in Physiology, 2018 During the last decade, optogenetics has emerged as a paradigm-shifting technique to monitor and steer the behavior of specific cell types in excitable tissues, including the heart.
Ramona A. Kopton +17 more
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