Results 21 to 30 of about 111,193 (254)
The Distribution and Role of the CFTR Protein in the Intracellular Compartments
Membranes, 2021 Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is caused by mutations in the gene encoding CFTR with the most common phenylalanine deletion at position 508. CFTR is an anion channel mainly conducting Cl− across
Agnieszka Lukasiak, Miroslaw Zajac
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LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
eLife, 2020 The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states
Jack P Green +12 more
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Role of quercetin in modulating chloride transport in the intestine
Frontiers in Physiology, 2016 Epithelial chloride channels provide the pathways for fluid secretion in the intestine. Cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCCs) are the main chloride channels in the luminal membrane of ...
Bo Yu +5 more
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Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
Frontiers in Pharmacology, 2017 Chloride channels play an essential role in a variety of physiological functions and in human diseases. Historically, the field of chloride channels has long been neglected owing to the lack of powerful selective pharmacological agents that are needed to
Jonas Friard +5 more
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Development of chloride channel modulators
Kidney International, 1995 Chloride channels are ubiquitously distributed, biophysically varied and functionally diverse. Despite the known contribution of chloride channels to the physiology of various cell types and the pathology of several diseases, high affinity ligands are not available to study these channels.
Singh, Ashvani K. +2 more
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Chloride channels in the eel intestine [PDF]
Journal of Experimental Biology, 1999 ABSTRACT Patches of freshly isolated epithelial cells from eel Anguilla anguilla intestine bathed by the same solution on both sides in the cell-attached configuration had conductances of 57.0±1.8 pS (for positive voltages) and 13.3±0.7 pS (for negative voltages) (means ± S.E.M., N=25).
, Bicho, , Ferreira, , Ferreira
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Сибирский научный медицинский журналChloride channels play a fundamental role in cellular homeostasis, influencing ion balance, pH regulation, and apoptotic signaling. While glutamate-gated chloride channels (GluCl) are traditionally restricted to invertebrates, recent evidence suggests ...
M. M. Akl, A. Ahmed
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Analecta Veterinaria, 2017 La diarrea es un desorden común en potrillos lactantes, y no se dispone de antidiarreicos antisecretorios específicos. El objetivo del estudio fue evaluar la seguridad y eficacia de una formulación en pasta con cubierta entérica del extracto botánico ...
Siobhan McAuliffe +6 more
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Ion channel expression in the developing enteric nervous system. [PDF]
PLoS ONE, 2015 The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry ...
Caroline S Hirst +10 more
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Positive modulation of the TMEM16B mediated currents by TRPV4 antagonist
Biochemistry and Biophysics Reports, 2021 Calcium-activated chloride channels (CaCCs) play important roles in many physiological processes and their malfunction is implicated in diverse pathologies such as cancer, asthma, and hypertension.
Adan Hernandez +3 more
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