Results 31 to 40 of about 2,972 (170)
Anoctamin-1 in the juvenile rat urinary bladder. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos +2 more
doaj +1 more source
The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration [PDF]
Pflügers Archiv - European Journal of Physiology, 2013 Members of the TMEM16 family have recently been described as Ca(2+)-activated Cl(-) channels. They have been implicated in cancer and appear to be associated with poor patient prognosis. Here, we investigate the role of TMEM16 channels in cell migration, which is largely unknown.
Jacobsen, K.S. +5 more
openaire +4 more sources
Frontiers in Pharmacology, 2023 Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park +20 more
doaj +1 more source
ANO1 Activation does not require Calmodulin [PDF]
Biophysical Journal, 2013 The Ca2+-activated Cl channel anoctamin-1 (ANO1, also called TMEM16A), a member of the Anoctamin superfamily, plays a variety of important physiological roles including epithelial fluid secretion. ANO1 is activated and gated by intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to ANO1 or whether an additional Ca2+-binding subunit
Yu, Kuai +4 more
openaire +1 more source
The Putative Ca2+-Acting Site in ANO1 [PDF]
Biophysical Journal, 2010 Ca2+-activated Cl- channels (CaCC) mediate numerous physiological functions including vectorial Cl- movements across epithelia. Anoctamin1/TMEM16A (Ano1) confers Ca2+-activated Cl- currents. ANO1 having TMs with a putative pore region between TM5 and TM6 shows similar biophysical as well as pharmacological properties as those known for endogenous CaCCs.
Oh, Uhtaek, Tak, Min Ho, Yang, Yung Duk
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Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +1 more source
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2022 Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
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Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells [PDF]
PeerJ, 2023 Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription ...
Yasuhiro Kimura +3 more
doaj +2 more sources
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj +1 more source