Results 31 to 40 of about 2,978 (169)
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
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ANO1 Activation does not require Calmodulin [PDF]
Biophysical Journal, 2013 The Ca2+-activated Cl channel anoctamin-1 (ANO1, also called TMEM16A), a member of the Anoctamin superfamily, plays a variety of important physiological roles including epithelial fluid secretion. ANO1 is activated and gated by intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to ANO1 or whether an additional Ca2+-binding subunit
Yu, Kuai +4 more
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The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration [PDF]
Pflügers Archiv - European Journal of Physiology, 2013 Members of the TMEM16 family have recently been described as Ca(2+)-activated Cl(-) channels. They have been implicated in cancer and appear to be associated with poor patient prognosis. Here, we investigate the role of TMEM16 channels in cell migration, which is largely unknown.
Jacobsen, K.S. +5 more
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Frontiers in Pharmacology, 2023 Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park +20 more
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The Putative Ca2+-Acting Site in ANO1 [PDF]
Biophysical Journal, 2010 Ca2+-activated Cl- channels (CaCC) mediate numerous physiological functions including vectorial Cl- movements across epithelia. Anoctamin1/TMEM16A (Ano1) confers Ca2+-activated Cl- currents. ANO1 having TMs with a putative pore region between TM5 and TM6 shows similar biophysical as well as pharmacological properties as those known for endogenous CaCCs.
Oh, Uhtaek, Tak, Min Ho, Yang, Yung Duk
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Medicina Oral Patología Oral y Cirugia Bucal, 2014 The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC.Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues. Lentiviral silencing ANO1 was used in SCC-25 cell line to study the cell migration and cell detachment.Immunohistochemical staining revealed that ...
Li, Yadong, Zhang, Jinsong, Hong, Suling
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Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
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Journal of Animal Reproduction and Biotechnology, 2022 Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
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Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.
PLoS ONE, 2016 Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression.
Yohan Seo +6 more
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Communications Biology, 2023 Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun +21 more
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