Results 21 to 30 of about 2,978 (169)
Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1 [PDF]
International Journal of Molecular Sciences, 2020 Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including human prostate cancer and oral squamous cell carcinomas. ANO1 plays a critical role in tumor growth and maintenance of these cancers. In this study, we have isolated two new compounds (1 and 2) and four known compounds (3–6) from Mallotus ...
Yohan Seo +14 more
openaire +2 more sources
ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer
Frontiers in Oncology, 2022 ANO1, a calcium-activated chloride channel (CACC), is also known as transmembrane protein 16A (TMEM16A). It plays a vital role in the occurrence, development, metastasis, proliferation, and apoptosis of various malignant tumors.
Saisai Guo, Linna Zhang, Na Li
doaj +1 more source
Brain Research Bulletin, 2023 Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models.
Ying Wang +13 more
doaj +1 more source
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter +4 more
openaire +4 more sources
ANO1: an additional key player in cyst growth [PDF]
Kidney International, 2014 Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an
Tetsuhiro, Tanaka, Masaomi, Nangaku
openaire +2 more sources
Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)
Journal of General Physiology, 2022 Numerous essential physiological processes depend on the TMEM16A-mediated Ca2+-activated chloride fluxes. Extensive structure–function studies have helped to elucidate the Ca2+ gating mechanism of TMEM16A, revealing a Ca2+-sensing element close to the anion pore that alters conduction.
José J. De Jesús-Pérez +7 more
openaire +2 more sources
Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells. [PDF]
PLoS ONE, 2017 Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to ...
Yohan Seo +6 more
doaj +1 more source
Anoctamin-1 in the juvenile rat urinary bladder. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos +2 more
doaj +1 more source
Ano1 as a regulator of proliferation
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011 Ano1 is a recently discovered Ca2+-activated Cl− channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in the gut. However, Ano1 is expressed on all classes of ICC, even those that do not contribute to generation of the slow wave, suggesting that Ano1 may have an alternate function in these cells.
Jennifer E, Stanich +7 more
openaire +3 more sources
Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis [PDF]
Journal of Biological Chemistry, 2011 Diabetes affects many organs including the stomach. Altered number and function of interstitial cells of Cajal (ICC), the gastrointestinal pacemaker cells, underlie a number of gastrointestinal motility disorders, including diabetic gastroparesis. In the muscle layers, ICC selectively express Ano1, thought to underlie classical Ca(2+)-activated Cl ...
Mazzone, Amelia +12 more
openaire +3 more sources