Results 21 to 30 of about 3,792 (162)

Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. [PDF]

PLoS ONE, 2012
Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and sensitive marker for the diagnosis of gastrointestinal stromal tumors (GIST) and has recently ...
Christian Ruiz, Joana Raquel Martins, Florian Rudin, Sandra Schneider, Tanja Dietsche, Claude A Fischer, Luigi Tornillo, Luigi M Terracciano, Rainer Schreiber, Lukas Bubendorf, Karl Kunzelmann   +10 more
doaj   +1 more source

Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Brain Research Bulletin, 2023
Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models.
Ying Wang, Weiwei Liang, Tianhang Wang, Chunting Zhang, Yueqing Yang, Chaohua Cong, Xudong Wang, Shuyu Wang, Di Wang, Di Huo, Hongyong Wang, Xiaoli Su, Xingli Tan, Honglin Feng   +13 more
doaj   +1 more source

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in Physiology, 2020
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj   +1 more source

Anoctamin-1 in the juvenile rat urinary bladder. [PDF]

PLoS ONE, 2014
PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos, Marcus J Drake, Bahareh Vahabi   +2 more
doaj   +1 more source

Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1

, 2021
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activated chloride ...
Oh-Bin Kwon, Sungwoo Jo, Yohan Seo, Seon Ju Park, Sion Lee, Uk Yeol Moon, Wan Namkung, Sungwoo Lee, Joo Han Woo, Hye In Oh, Sung Baek Jeong   +10 more
core   +1 more source

ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma [PDF]

, 2021
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that derive from the mucosal epithelium of the upper aerodigestive tract and present high mortality rate.
Karhemo Piia-Riitta, Filippou Artemis, Klefström Juha, Joensuu Heikki, Pehkonen Henna, Monni Outi, Mäkitie Antti A, Nieminen Anni I, Väänänen Juho, Grénman Reidar   +9 more
core   +3 more sources

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]

, 2014
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca2+-activated Cl- channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in
Sauter, Daniel Rafael Peter, E. H. Larsen, Pedersen, Stine Helene Falsig, Hoffmann, Else Kay, Larsen, Erik Hviid, I. Novak, Novak, Ivana, S. F. Pedersen, D. R. P. Sauter, E. K. Hoffmann   +9 more
core   +1 more source

Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1

, 2020
Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including human prostate cancer and oral squamous cell carcinomas. ANO1 plays a critical role in tumor growth and maintenance of these cancers.
Phan Van Kiem, Chau Van Minh, Yechan Lee, Yohan Seo, Duong Thi Hai Yen, Yunkyung Heo, Seung Hyun Kim, Nguyen Hoang Anh, Nguyen Hoai Nam, Sungwoo Jo, So-Hyeon Park, Wan Namkung, Dongkyu Jeon, Bui Huu Tai, Nguyen Xuan Nhiem   +14 more
core   +1 more source

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Frontiers in Pharmacology, 2023
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park, Raju Das, Nguyen Xuan Nhiem, Nguyen Xuan Nhiem, Sung Baek Jeong, Minuk Kim, Dongguk Kim, Hye In Oh, Su-Hyeon Cho, Oh-Bin Kwon, Jae-Hyeog Choi, Chul Soon Park, Song-Rae Kim, Uk Yeol Moon, Boksik Cha, Dong Kyu Choi, Sungwoo Lee, Wan Namkung, Joohan Woo, Joohan Woo, Yohan Seo   +20 more
doaj   +1 more source

Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.

PLoS ONE, 2016
Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression.
Yohan Seo, Ho K Lee, Jinhong Park, Dong-Kyu Jeon, Sungwoo Jo, Minjae Jo, Wan Namkung   +6 more
doaj   +1 more source