Results 21 to 30 of about 2,972 (170)

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Frontiers in Bioscience-Landmark, 2022
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei   +7 more
doaj   +1 more source

Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1 [PDF]

International Journal of Molecular Sciences, 2020
Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including human prostate cancer and oral squamous cell carcinomas. ANO1 plays a critical role in tumor growth and maintenance of these cancers. In this study, we have isolated two new compounds (1 and 2) and four known compounds (3–6) from Mallotus ...
Yohan Seo, Nguyen Hoang Anh, Yunkyung Heo, So-Hyeon Park, Phan Van Kiem, Yechan Lee, Duong Thi Hai Yen, Sungwoo Jo, Dongkyu Jeon, Bui Huu Tai, Nguyen Hoai Nam, Chau Van Minh, Seung Hyun Kim, Nguyen Xuan Nhiem, Wan Namkung   +14 more
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Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Brain Research Bulletin, 2023
Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models.
Ying Wang, Weiwei Liang, Tianhang Wang, Chunting Zhang, Yueqing Yang, Chaohua Cong, Xudong Wang, Shuyu Wang, Di Wang, Di Huo, Hongyong Wang, Xiaoli Su, Xingli Tan, Honglin Feng   +13 more
doaj   +1 more source

ANO1: an additional key player in cyst growth [PDF]

Kidney International, 2014
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an
Tetsuhiro, Tanaka, Masaomi, Nangaku
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ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter, Novak, Ivana, Pedersen, Stine Helene Falsig, Larsen, Erik Hviid, Hoffmann, Else Kay   +4 more
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Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)

Journal of General Physiology, 2022
Numerous essential physiological processes depend on the TMEM16A-mediated Ca2+-activated chloride fluxes. Extensive structure–function studies have helped to elucidate the Ca2+ gating mechanism of TMEM16A, revealing a Ca2+-sensing element close to the anion pore that alters conduction.
José J. De Jesús-Pérez, Ana E. López-Romero, Odalys Posadas, Guadalupe Segura-Covarrubias, Iván Aréchiga-Figueroa, Braulio Gutiérrez-Medina, Patricia Pérez-Cornejo, Jorge Arreola   +7 more
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Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells. [PDF]

PLoS ONE, 2017
Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to ...
Yohan Seo, Kunhi Ryu, Jinhong Park, Dong-Kyu Jeon, Sungwoo Jo, Ho K Lee, Wan Namkung   +6 more
doaj   +1 more source

Ano1 as a regulator of proliferation

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
Ano1 is a recently discovered Ca2+-activated Cl− channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in the gut. However, Ano1 is expressed on all classes of ICC, even those that do not contribute to generation of the slow wave, suggesting that Ano1 may have an alternate function in these cells.
Jennifer E, Stanich, Simon J, Gibbons, Seth T, Eisenman, Michael R, Bardsley, Jason R, Rock, Brian D, Harfe, Tamas, Ordog, Gianrico, Farrugia   +7 more
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Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis [PDF]

Journal of Biological Chemistry, 2011
Diabetes affects many organs including the stomach. Altered number and function of interstitial cells of Cajal (ICC), the gastrointestinal pacemaker cells, underlie a number of gastrointestinal motility disorders, including diabetic gastroparesis. In the muscle layers, ICC selectively express Ano1, thought to underlie classical Ca(2+)-activated Cl ...
Mazzone, Amelia, Bernard, Cheryl E., Strege, Peter R., Beyder, Arthur, Galietta, Luis J. V., Pasricha, Pankaj J., Rae, James L., Parkman, Henry P., Linden, David R., Szurszewski, Joseph H., Ördög, Tamas, Gibbons, Simon J., Farrugia, Gianrico   +12 more
openaire   +3 more sources

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in Physiology, 2020
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj   +1 more source