Results 21 to 30 of about 8,763 (208)

Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]

Frontiers in Pharmacology
Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo, Yohan Seo, Sion Lee, Raju Das, Sung Baek Jeong, Chul Soon Park, Minuk Kim, Deok Kyu Yoon, Armin Sultana, Kantu Das, Jae-Eon Lee, Yong Hyun Jeon, Phan Thi Thanh Huong, Nguyen Xuan Nhiem, Joohan Woo, Joohan Woo   +15 more
doaj   +2 more sources

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma [PDF]

Scientific Reports
Human papilloma virus-negative head and neck squamous cell carcinoma (HNSCC) frequently harbors 11q13 amplifications. Among the oncogenes at this locus, CCND1 and ANO1 are linked to poor prognosis; however, their individual roles in treatment resistance ...
Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer   +5 more
doaj   +2 more sources

Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 [PDF]

International Journal of Molecular Sciences, 2021
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activated chloride channel (CaCC) overexpressed in various carcinomas.
Yohan Seo, Sung Baek Jeong, Joo Han Woo, Oh-Bin Kwon, Sion Lee, Hye In Oh, Sungwoo Jo, Seon Ju Park, Wan Namkung, Uk Yeol Moon, Sungwoo Lee   +10 more
openaire   +2 more sources

Prognostic significance of ANO1 expression in cancers

Medicine, 2021
Abstract Background: Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of ANO1 in cancers. Methods: A total of 1760 patients from 7 eligible studies were included into the analysis.
Congxiao Zhang, Haini Li, Jing Gao, Xiaoqing Cui, Shengmei Yang, Zongtao Liu   +5 more
openaire   +2 more sources

Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1 [PDF]

International Journal of Molecular Sciences, 2020
Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including human prostate cancer and oral squamous cell carcinomas. ANO1 plays a critical role in tumor growth and maintenance of these cancers. In this study, we have isolated two new compounds (1 and 2) and four known compounds (3–6) from Mallotus ...
Yohan Seo, Nguyen Hoang Anh, Yunkyung Heo, So-Hyeon Park, Phan Van Kiem, Yechan Lee, Duong Thi Hai Yen, Sungwoo Jo, Dongkyu Jeon, Bui Huu Tai, Nguyen Hoai Nam, Chau Van Minh, Seung Hyun Kim, Nguyen Xuan Nhiem, Wan Namkung   +14 more
openaire   +2 more sources

Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Brain Research Bulletin, 2023
Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models.
Ying Wang, Weiwei Liang, Tianhang Wang, Chunting Zhang, Yueqing Yang, Chaohua Cong, Xudong Wang, Shuyu Wang, Di Wang, Di Huo, Hongyong Wang, Xiaoli Su, Xingli Tan, Honglin Feng   +13 more
doaj   +1 more source

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +2 more sources

ANO1: an additional key player in cyst growth [PDF]

Kidney International, 2014
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an
Tetsuhiro, Tanaka, Masaomi, Nangaku
openaire   +2 more sources

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter, Novak, Ivana, Pedersen, Stine Helene Falsig, Larsen, Erik Hviid, Hoffmann, Else Kay   +4 more
openaire   +4 more sources

Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)

Journal of General Physiology, 2022
Numerous essential physiological processes depend on the TMEM16A-mediated Ca2+-activated chloride fluxes. Extensive structure–function studies have helped to elucidate the Ca2+ gating mechanism of TMEM16A, revealing a Ca2+-sensing element close to the anion pore that alters conduction.
José J. De Jesús-Pérez, Ana E. López-Romero, Odalys Posadas, Guadalupe Segura-Covarrubias, Iván Aréchiga-Figueroa, Braulio Gutiérrez-Medina, Patricia Pérez-Cornejo, Jorge Arreola   +7 more
openaire   +2 more sources