Results 41 to 50 of about 2,972 (170)
Communications Biology, 2023 Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun +21 more
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Medicina Oral Patología Oral y Cirugia Bucal, 2014 The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC.Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues. Lentiviral silencing ANO1 was used in SCC-25 cell line to study the cell migration and cell detachment.Immunohistochemical staining revealed that ...
Li, Yadong, Zhang, Jinsong, Hong, Suling
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PLoS ONE, 2015 The calcium-activated chloride channel Ano1 (TMEM16A) is overexpressed in many tumors. Although Ano1 overexpression is found in breast cancer due to 11q13 amplification, it remains unclear whether signaling pathways are involved in Ano1 overexpression ...
Huizhe Wu +11 more
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Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.
PLoS ONE, 2016 Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression.
Yohan Seo +6 more
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ANO1 plays a critical role in prostatic hyperplasia [PDF]
Proceedings of the National Academy of Sciences, 2015 Benign prostatic hyperplasia (BPH) is a troubling problem that affects many older men worldwide (1). This condition poses a treatment challenge because current pharmacologic therapies can have untoward side effects. A better understanding of the pathogenesis of BPH would allow for the development of novel therapies for this condition.
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TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology, 2023 Abstract Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is highly permeable to calcium. This channel is strongly expressed in skin keratinocytes and is involved in warmth sensation, itch, wound healing and secretion of several cytokines ...
Yu Yamanoi +5 more
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TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries [PDF]
Circulation Research, 2012 Rationale: Pressure-induced arterial depolarization and constriction (the myogenic response) is a smooth muscle cell (myocyte)-specific mechanism that controls regional organ blood flow and systemic blood pressure.
Simon, Bulley +6 more
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The Function and Mechanism of TMEM16A/ANO1 in Pancreatic Cancer [PDF]
Biophysical Journal, 2017 Pancreatic cancer is the eighth leading cause of cancer death and is difficult to treat because clinical presentation is often late, and the disease is resistant to conventional chemotherapy. About 57% of pancreatic cancer patients are diagnosed at distant metastasis status and five-year survival rate is only 2%.
Yonjung Kim, Hyung Soon Park
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British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
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Cellular Physiology and Biochemistry, 2014 Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco +10 more
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