Results 41 to 50 of about 8,763 (208)

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Frontiers in Pharmacology, 2023
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park, Raju Das, Nguyen Xuan Nhiem, Nguyen Xuan Nhiem, Sung Baek Jeong, Minuk Kim, Dongguk Kim, Hye In Oh, Su-Hyeon Cho, Oh-Bin Kwon, Jae-Hyeog Choi, Chul Soon Park, Song-Rae Kim, Uk Yeol Moon, Boksik Cha, Dong Kyu Choi, Sungwoo Lee, Wan Namkung, Joohan Woo, Joohan Woo, Yohan Seo   +20 more
doaj   +1 more source

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]

, 2016
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R, Burgoyne, Adam M, Chan, Jonathan C, Chmielecki, Juliann, Gao, Fei, Harismendy, Olivier, Kendrick, Michael L, Lee, Tracy E, Leonard, Stephanie Y, Mao, Junhao, Morosini, Deborah, Ordog, Tamas, Ross, Jeffrey S, Shi, Eileen, Sicklick, Jason K, Siena, Martina De, Syed, Sabriya A, Tang, Chih-Min, Wang, Kai   +18 more
core   +2 more sources

The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration [PDF]

Pflügers Archiv - European Journal of Physiology, 2013
Members of the TMEM16 family have recently been described as Ca(2+)-activated Cl(-) channels. They have been implicated in cancer and appear to be associated with poor patient prognosis. Here, we investigate the role of TMEM16 channels in cell migration, which is largely unknown.
Jacobsen, K.S., Zeeberg, K., Sauter, Daniel Rafael Peter, Poulsen, K.A., Hoffmann, Else Kay, Schwab, A.   +5 more
openaire   +4 more sources

Involvement of the transmembrane protein p23 in biosynthetic protein transport [PDF]

, 1997
The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Alcalde, Allan, Aniento, Aniento, Ansorge, Belden, Bergmann, Blum, Bomsel, Celis, Church, Cole, Cosson, Dupree, Elrod-Erickson, Emans, Evan, Fiedler, Griffiths, Griffiths, Griffiths, Griffiths, Gruenberg, Gruenberg, Gruenberg, Hauri, Jackson, Klausner, Kozak, Kreis, Kreis, Kreis, Laemmli, Letourneur, Letourneur, Lewis, Lippincott-Schwartz, Lotti, Lowe, Ludwig, Luzio, Nakamura, Nielsen, Nilsson, Nilsson, Oprins, Orci, Orci, Palade, Pelham, Pepperkok, Pevsner, Pryer, Quinn, Rambourg, Rios, Rogalski, Rothman, Saraste, Saraste, Scheel, Schimmöller, Schweizer, Schweizer, Serafini, Sohn, Stamnes, Subramaniam, Sönnichsen, Tang, Tang, Tisdale, Trowbridge, Wada, Warren   +74 more
core   +2 more sources

The Putative Ca2+-Acting Site in ANO1 [PDF]

Biophysical Journal, 2010
Ca2+-activated Cl- channels (CaCC) mediate numerous physiological functions including vectorial Cl- movements across epithelia. Anoctamin1/TMEM16A (Ano1) confers Ca2+-activated Cl- currents. ANO1 having TMs with a putative pore region between TM5 and TM6 shows similar biophysical as well as pharmacological properties as those known for endogenous CaCCs.
Oh, Uhtaek, Tak, Min Ho, Yang, Yung Duk
openaire   +1 more source

Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]

, 2015
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair, Anja Godfrey, Bailey, Bark-Jones, Beatty, Ben-Bassat, Bergbauer, Bhende, Bhende, Broderick, Carey, Chang, Chi, Farnham, Feederle, Feng, Flemington, Flower, Gentleman, Gordon Peters, Grabherr, Gupta, Gustems, Halder, Harshil Patel, Heather, Hollyoake, Hsu, Huang da, Huang da, Ijiel B. Naranjo Perez-Fernandez, Inman, Israel, Jiang, Jianmin Zuo, Kalla, Kalla, Kay Osborn, Kenney, Kenney, Klug, Krig, Kuppers, Li, Lieberman, Lieberman, Lieberman, Longnecker, Ma, Machanick, Martin Rowe, McClellan, Miller, Molyneux, Nicolae Balan, Pruitt, Rajaei Al-Mohammad, Ramasubramanyan, Ramasubramanyan, Richard G. Jenner, Rickinson, Rowe, Rowe, Scacheri, Shannon-Lowe, Sharada Ramasubramanyan, Takada, Thorvaldsdottir, Tsai, Tsang, Vetsika, Whyte, Yang, Young, Young, Yuan, Zuo, Zuo   +77 more
core   +1 more source

Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1

Communications Biology, 2023
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li   +21 more
doaj   +1 more source

Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells [PDF]

PeerJ, 2023
Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription ...
Yasuhiro Kimura, Masahiro Shinoda, Masaharu Shinkai, Takeshi Kaneko   +3 more
doaj   +2 more sources

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source