Results 41 to 50 of about 2,978 (169)
Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells [PDF]
PeerJ, 2023 Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription ...
Yasuhiro Kimura +3 more
doaj +2 more sources
PLoS ONE, 2015 The calcium-activated chloride channel Ano1 (TMEM16A) is overexpressed in many tumors. Although Ano1 overexpression is found in breast cancer due to 11q13 amplification, it remains unclear whether signaling pathways are involved in Ano1 overexpression ...
Huizhe Wu +11 more
doaj +1 more source
ANO1 plays a critical role in prostatic hyperplasia [PDF]
Proceedings of the National Academy of Sciences, 2015 Benign prostatic hyperplasia (BPH) is a troubling problem that affects many older men worldwide (1). This condition poses a treatment challenge because current pharmacologic therapies can have untoward side effects. A better understanding of the pathogenesis of BPH would allow for the development of novel therapies for this condition.
openaire +2 more sources
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj +1 more source
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology, 2023 Abstract Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is highly permeable to calcium. This channel is strongly expressed in skin keratinocytes and is involved in warmth sensation, itch, wound healing and secretion of several cytokines ...
Yu Yamanoi +5 more
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TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries [PDF]
Circulation Research, 2012 Rationale: Pressure-induced arterial depolarization and constriction (the myogenic response) is a smooth muscle cell (myocyte)-specific mechanism that controls regional organ blood flow and systemic blood pressure.
Simon, Bulley +6 more
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The Function and Mechanism of TMEM16A/ANO1 in Pancreatic Cancer [PDF]
Biophysical Journal, 2017 Pancreatic cancer is the eighth leading cause of cancer death and is difficult to treat because clinical presentation is often late, and the disease is resistant to conventional chemotherapy. About 57% of pancreatic cancer patients are diagnosed at distant metastasis status and five-year survival rate is only 2%.
Yonjung Kim, Hyung Soon Park
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Andrology, EarlyView.ABSTRACT Background Spontaneous phasic contractions (SPCs) in the epididymal duct play an important role in transport and maturation of sperm. In proximal cauda of the rat epididymis, platelet‐derived growth factor receptor α (PDGFRα)‐positive smooth muscle cells (SMCs) generate ANO1 Ca2+‐activated chloride channels (CaCCs)‐dependent spontaneous ...
Wataru Kudo +5 more
wiley +1 more source
PLoS ONE, 2015 Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl-
Linghan Jia +4 more
doaj +1 more source