Results 61 to 70 of about 2,972 (170)

Does calmodulin regulate the bicarbonate permeability of ANO1/TMEM16A or not? [PDF]

Journal of General Physiology, 2014
The role of calmodulin in the activation of Ca2+-activated Cl− channels (CaCCs) has been an important topic over the past three decades of CaCC research. Recently, the discovery of ANO1/TMEM16 as a component of CaCC raised the question of whether calmodulin modulates ANO1 activity ([Tian et al.,
Jung, Jinsei, Lee, Min Goo
openaire   +3 more sources

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]

PLoS ONE, 2014
Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
doaj   +1 more source

Detection of ANO1 mRNA in PBMCs is a promising method for GISTs diagnosis [PDF]

Scientific Reports, 2019
AbstractANO1 is a calcium-activated chloride channel protein that has been used to diagnose GISTs after tissue biopsy. Recently, ANO1 mRNA amplification in the blood has received considerable attention as a useful method for the diagnosis of GISTs. The aim of this study was to evaluate the diagnostic ability of ANO1 mRNA in distinguishing GIST patients
Li, Haini, Wu, Ancheng, Zhu, Wuhui, Hou, Feng, Cheng, Shaoyun, Cao, Jinpeng, Yan, Yufen, Zhang, Congxiao, Liu, Zongtao   +8 more
openaire   +2 more sources

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin [PDF]

Journal of General Physiology, 2014
The Ca2+-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to Ano1 or whether phosphorylation or additional Ca2+-binding subunits like calmodulin (CaM) are required. Here
Yu, Kuai, Zhu, Jinqiu, Qu, Zhiqiang, Cui, Yuan-Yuan, Hartzell, H. Criss   +4 more
openaire   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

ANO1 taking center stage: Blood pressure regulation in SHRs [PDF]

Journal of Molecular and Cellular Cardiology, 2015
Calcium-activated chloride channels (CaCCs) were first described in 1981, when injection of Ca2+ or Ca2+ ionophore into Rana pipiens eggs initiated a transient shift to positive membrane potentials in a chloride-dependent manner [1]. Major biophysical features of CaCCs include: 1) ability of being activated by cytosolic Ca2+ in the submicromolar range;
Qiang Li, Hua Cai
openaire   +2 more sources

Sympathetic Overactivation Drives Neurogenic Alveolar Epithelial Pyroptosis via the PIEZO2‐ER Stress Pathway in Acute Lung Injury Following Intracerebral Hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Following intracerebral hemorrhage, sympathetic overactivation drives acute lung injury via norepinephrine‐induced VPS35 upregulation. VPS35 promotes PIEZO2‐mediated calcium influx and impairs ATP2A2‐dependent ER calcium reuptake, triggering ER stress and NLRP3‐pyroptosis.
Shuai Han, Zirui Wang, Qiuyue Zheng, Feng Guo, Yinggang Xiao, Zi Wang, Tianfeng Huang, Yongxin Liang, Bingchun Yan, Ju Gao   +9 more
wiley   +1 more source