Results 81 to 90 of about 2,978 (169)

Mechanisms underlying gastric antral slow waves – a human perspective

The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley   +1 more source

ANO1 stabilizes partial EMT to drive colorectal cancer metastasis through PI3K/AKT/mTOR and ERK signaling pathways

Scientific Reports
Colorectal cancer (CRC) metastasis remains a clinically intractable challenge, where the partial epithelial-mesenchymal transition (partial EMT) state is a key driver of metastatic plasticity and treatment resistance.
Fei Wu, Kun Zhang, Zhenwu Du, Xin Li, Longfei Yang, Linxian Zhao, Bo Cheng, Lili Nie, Qiwei Yang, Yujie Sui   +9 more
doaj   +1 more source

Integrated analysis of genomic and transcriptomic profiles identified a prognostic immunohistochemistry panel for esophageal squamous cell cancer

Cancer Medicine, 2020
Background The poor outcome of patients with esophageal squamous cell carcinoma (ESCC) highlights the importance of the identification of novel effective prognostic biomarkers. We aimed to identify a clinically applicable prognostic immunohistochemistry (
Yue Yu, Zhihua Li, Chenjun Huang, Haisheng Fang, Fei Zhao, Yue Zhou, Xianglong Pan, Qifan Li, Yu Zhuang, Liang Chen, Jing Xu, Wei Wang   +11 more
doaj   +1 more source

Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands

Heliyon, 2019
Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou, Yoshiyuki Shibukawa, Maki Kimura, Naoki Sugihara   +3 more
doaj   +1 more source

ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway

Scientific Reports, 2017
As a newly identified factor in calcium-activated chloride channel, ANO1 participates in various physiological processes like proliferation and differentiation, and expresses in human cardiac fibroblasts.
Yao Gao, Yan Mei Zhang, Li Jun Qian, Ming Chu, Jian Hong, Di Xu   +5 more
doaj   +1 more source

Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells

Animal Cells and Systems, 2019
Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear.
Jae-Young Kim, Hwa Young Youn, June Choi, Seung Kuk Baek, Soon Young Kwon, Bok Kee Eun, Jae-Yong Park, Kyoung Ho Oh   +7 more
doaj   +1 more source

Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells

Frontiers in Physiology, 2017
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues.
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa   +6 more
doaj   +1 more source

Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis

Scientific Reports
Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the metastatic potential of prostate cancer and the possible significance of epigenetic alteration in this process ...
Yonghwan Shin, Sungmin Kim, Woojin An
doaj   +1 more source

Low dose cadmium exposure regulates miR-381–ANO1 interaction in airway epithelial cells

Scientific Reports
Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death worldwide. Cigarette smoke which has approximately 2–3 µg of Cadmium (Cd) per cigarette contributes to the environmental exposure and development and severity of COPD.
Pooja Singh, Fu Jun Li, Kevin Dsouza, Crystal T Stephens, Huaxiu Zheng, Abhishek Kumar, Mark T. Dransfield, Veena B Antony   +7 more
doaj   +1 more source

Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin

Experimental and Molecular Medicine, 2019
Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee, Gyu-Sang Hong, Sung Hoon Lee, Hyungsup Kim, Ajung Kim, Eun Mi Hwang, Jiyoon Kim, Min Goo Lee, Jin-Young Yang, Mi-Na Kweon, Chung-Ming Tse, Donowitz Mark, Uhtaek Oh   +12 more
doaj   +1 more source