Results 81 to 90 of about 8,763 (208)

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]

PLoS ONE, 2014
Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Detection of ANO1 mRNA in PBMCs is a promising method for GISTs diagnosis [PDF]

Scientific Reports, 2019
AbstractANO1 is a calcium-activated chloride channel protein that has been used to diagnose GISTs after tissue biopsy. Recently, ANO1 mRNA amplification in the blood has received considerable attention as a useful method for the diagnosis of GISTs. The aim of this study was to evaluate the diagnostic ability of ANO1 mRNA in distinguishing GIST patients
Li, Haini, Wu, Ancheng, Zhu, Wuhui, Hou, Feng, Cheng, Shaoyun, Cao, Jinpeng, Yan, Yufen, Zhang, Congxiao, Liu, Zongtao   +8 more
openaire   +2 more sources

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin [PDF]

Journal of General Physiology, 2014
The Ca2+-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to Ano1 or whether phosphorylation or additional Ca2+-binding subunits like calmodulin (CaM) are required. Here
Yu, Kuai, Zhu, Jinqiu, Qu, Zhiqiang, Cui, Yuan-Yuan, Hartzell, H. Criss   +4 more
openaire   +2 more sources

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Large‐scale calculations of excitation energies in coupled cluster theory : The singlet excited states of benzene [PDF]

, 1996
Algorithms for calculating singlet excitation energies in the coupled cluster singles and doubles (CCSD) model are discussed and an implementation of an atomic‐integral direct algorithm is presented.
Alfredo Sánchez de Merás, Asger Halkier, Bauschlicher C. W., Henrik Koch, Hirao K., Maurice J., Monkhorst H. J., Nakashima N., Oddershede J., Ove Christiansen, Palmer M. H., Parmenter C. S., Poul Jo/rgensen, Trygve Helgaker, Whetten R. L.   +14 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

ANO1 taking center stage: Blood pressure regulation in SHRs [PDF]

Journal of Molecular and Cellular Cardiology, 2015
Calcium-activated chloride channels (CaCCs) were first described in 1981, when injection of Ca2+ or Ca2+ ionophore into Rana pipiens eggs initiated a transient shift to positive membrane potentials in a chloride-dependent manner [1]. Major biophysical features of CaCCs include: 1) ability of being activated by cytosolic Ca2+ in the submicromolar range;
Qiang Li, Hua Cai
openaire   +2 more sources