Results 81 to 90 of about 2,972 (170)

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Mechanisms underlying gastric antral slow waves – a human perspective

The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley   +1 more source

TMEM16A Contributes to Calcium‐Activated Chloride Currents and Membrane Potential Changes in the Mouse Oocyte

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT Oscillations in intracellular Ca2+ [Ca2+]i are essential for mouse oocyte activation following fertilization. These [Ca2+]i oscillations also induce repetitive hyperpolarizations in the membrane potential (Em). The present study aimed to identify the channels underlying the Em hyperpolarizations.
Sarah Dalati, Vanessa J. Jones, Margot L. Day   +2 more
wiley   +1 more source

ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway

Scientific Reports, 2017
As a newly identified factor in calcium-activated chloride channel, ANO1 participates in various physiological processes like proliferation and differentiation, and expresses in human cardiac fibroblasts.
Yao Gao, Yan Mei Zhang, Li Jun Qian, Ming Chu, Jian Hong, Di Xu   +5 more
doaj   +1 more source

Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands

Heliyon, 2019
Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou, Yoshiyuki Shibukawa, Maki Kimura, Naoki Sugihara   +3 more
doaj   +1 more source

Integrated analysis of genomic and transcriptomic profiles identified a prognostic immunohistochemistry panel for esophageal squamous cell cancer

Cancer Medicine, 2020
Background The poor outcome of patients with esophageal squamous cell carcinoma (ESCC) highlights the importance of the identification of novel effective prognostic biomarkers. We aimed to identify a clinically applicable prognostic immunohistochemistry (
Yue Yu, Zhihua Li, Chenjun Huang, Haisheng Fang, Fei Zhao, Yue Zhou, Xianglong Pan, Qifan Li, Yu Zhuang, Liang Chen, Jing Xu, Wei Wang   +11 more
doaj   +1 more source

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma

Scientific Reports
Human papilloma virus-negative head and neck squamous cell carcinoma (HNSCC) frequently harbors 11q13 amplifications. Among the oncogenes at this locus, CCND1 and ANO1 are linked to poor prognosis; however, their individual roles in treatment resistance ...
Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer   +5 more
doaj   +1 more source

Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells

Animal Cells and Systems, 2019
Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear.
Jae-Young Kim, Hwa Young Youn, June Choi, Seung Kuk Baek, Soon Young Kwon, Bok Kee Eun, Jae-Yong Park, Kyoung Ho Oh   +7 more
doaj   +1 more source

Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells

Frontiers in Physiology, 2017
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues.
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa   +6 more
doaj   +1 more source

Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis

Scientific Reports
Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the metastatic potential of prostate cancer and the possible significance of epigenetic alteration in this process ...
Yonghwan Shin, Sungmin Kim, Woojin An
doaj   +1 more source