Results 71 to 80 of about 3,792 (162)
The Journal of Physiology, EarlyView.Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista +11 more
wiley +1 more source
Idebenone inhibits ANO1 in FRT-ANO1 and PC3 cells.
, 2015 (A) (left) Whole-cell ANO1 current recorded at a holding potential at 0 mV and pulsing to voltages between ± 80 mV (in steps of 20 mV) in the absence and presence of 10 μM idebenone. ANO1 was activated by 100 μM ATP.
Jinhong Park (161037) +6 more
core +1 more source
Comprehensive analysis of Ano1 protein expression in normal tissues.
, 2012 #Mucosa and mucous glands were negative.Summary of normal tissues with detectable Ano1 protein expression. Most normal tissues do not express Ano1. Only gall bladder, stomach and duodenum express Ano1 (A).
Karl Kunzelmann (80303) +10 more
core +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan +24 more
wiley +1 more source
Upregulation of ANO1 expression in human lung cancer cell lines.
, 2015 Top panel: representative western blot images of ANO1 expression in different lung cell lines. Bottom panel: statistical analysis bar chart (n = 3) of ANO1 relative levels in NCI-H520, GLC82, Calu-3, A549 and H1299 cell lines (compared with normal 2BS ...
Min Lu (238723) +4 more
core +1 more source
Cell-Specific Mechanisms of Microrna Modulation of Anoctamin-1 (ANO1) in Oral Cancer
, 2023 Anoctamin-1 (ANO1) is a calcium-gated chloride ion channel with multiple physiological roles, including transepithelial ion transport, smooth muscle contraction, salivary secretion, and nociception.
Hou, Daniel
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.Following intracerebral hemorrhage, sympathetic overactivation drives acute lung injury via norepinephrine‐induced VPS35 upregulation. VPS35 promotes PIEZO2‐mediated calcium influx and impairs ATP2A2‐dependent ER calcium reuptake, triggering ER stress and NLRP3‐pyroptosis.
Shuai Han +9 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Anoctamin1 (Ca2+-activated Cl- channel, ANO1) is a specific marker of the interstitial cells of Cajal (ICC) in the gastrointestinal tract, and are candidate proteins that can function as pacemaker channels. Recently, novel selective ANO1
Seok Choi +6 more
doaj +1 more source
Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
Frontiers in ImmunologyBackgroundAminooctylamine (ANO1) plays an oncogenic role in various cancers. However. its role in pancreatic cancer (PC) has rarely been studied. This study investigated the prognostic value of ANO1 and its correlation with the tumor microenvironment ...
Guangnian Zhang +12 more
doaj +1 more source