Results 71 to 80 of about 8,763 (208)
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source
Under pressure: Ano1 mediates pressure sensing in the lymphatic system [PDF]
Journal of General Physiology, 2019 Tembo and Carlson reflect on recent work describing a new role for Ano1 in lymphatic collecting vessels.
Maiwase Tembo, Anne E. Carlson
openaire +2 more sources
Full configuration interaction calculation of BeH adiabatic states [PDF]
, 2008 An all-electron full configuration interaction (FCI) calculation of the adiabatic potential energy curves of some of the lower states of BeH molecule is presented.
A. M. Velasco +10 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington +4 more
wiley +1 more source
Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1 [PDF]
International Journal of Molecular Sciences, 2019 Receptor-type ion channels are critical for detection of noxious stimuli in primary sensory neurons. Transient receptor potential (TRP) channels mediate pain sensations and promote a variety of neuronal signals that elicit secondary neural functions (such as calcitonin gene-related peptide [CGRP] secretion), which are important for physiological ...
Takayama, Yasunori +3 more
openaire +2 more sources
PLoS ONE, 2015 Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl-
Linghan Jia +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley +1 more source
Transcriptional activation of ANO1 promotes gastric cancer progression
Biochemical and Biophysical Research Communications, 2019 The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. The GC-related molecular mechanisms underlying invasion and metastasis are not well understood. In this study, we investigated the functional role of ANO1 in GC progression.
Xiaoqing Zeng +7 more
openaire +2 more sources
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
Does calmodulin regulate the bicarbonate permeability of ANO1/TMEM16A or not? [PDF]
Journal of General Physiology, 2014 The role of calmodulin in the activation of Ca2+-activated Cl− channels (CaCCs) has been an important topic over the past three decades of CaCC research. Recently, the discovery of ANO1/TMEM16 as a component of CaCC raised the question of whether calmodulin modulates ANO1 activity ([Tian et al.,
Jung, Jinsei, Lee, Min Goo
openaire +3 more sources