Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +1 more source
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.
PLoS ONE, 2016 Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression.
Yohan Seo +6 more
doaj +1 more source
HCO3- transport through anoctamin/transmembrane protein ANO1/TMEM16A, in pancreatic acinar cells, regulates luminal pH [PDF]
, 2016 The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Han, Yanfeng +2 more
core +1 more source
PLoS ONE, 2015 The calcium-activated chloride channel Ano1 (TMEM16A) is overexpressed in many tumors. Although Ano1 overexpression is found in breast cancer due to 11q13 amplification, it remains unclear whether signaling pathways are involved in Ano1 overexpression ...
Huizhe Wu +11 more
doaj +1 more source
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of Cajal [PDF]
, 2013 BACKGROUND: Hyperpolarization-activated cyclic nucleotide (HCN) channels are pacemaker channels that regulate heart rate and neuronal rhythm in spontaneously active cardiac and neuronal cells.
Chan Guk Park +9 more
core +1 more source
ANO1 plays a critical role in prostatic hyperplasia [PDF]
Proceedings of the National Academy of Sciences, 2015 Benign prostatic hyperplasia (BPH) is a troubling problem that affects many older men worldwide (1). This condition poses a treatment challenge because current pharmacologic therapies can have untoward side effects. A better understanding of the pathogenesis of BPH would allow for the development of novel therapies for this condition.
openaire +2 more sources
Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites [PDF]
, 2017 Ca2+ signaling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signaling precision requires localized rises in the ...
Courjaret, Raphael +2 more
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TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology, 2023 Abstract Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is highly permeable to calcium. This channel is strongly expressed in skin keratinocytes and is involved in warmth sensation, itch, wound healing and secretion of several cytokines ...
Yu Yamanoi +5 more
openaire +3 more sources
Cellular Expression Profile for Interstitial Cells of Cajal in Bladder - A Cell Often Misidentified as Myocyte or Myofibroblast [PDF]
, 2012 Background: Interstitial cells of Cajal (ICC) have been identified in urinary bladder of several species, but their presence in mice remains uncertain.
Hill, Warren Gary +2 more
core +2 more sources