Results 101 to 110 of about 8,763 (208)

Caracterização e dissimilaridade entre populações de cenoura. [PDF]

open access: yes, 2013
Verificou-se a efetividade de caracteres fenotipicos na caracterização e dissimilaridade, bem como a distânica genética entre populações melhoradas e cultivares de ...
CARVALHO, A. D. F. de   +2 more
core   +2 more sources

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han   +8 more
wiley   +1 more source

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

open access: yes, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah   +6 more
core   +2 more sources

Effects of Ca2+-Activated Cl- Channel ANO1inhibitors on Pacemaker Activity in Interstitial Cells of Cajal

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: Anoctamin1 (Ca2+-activated Cl- channel, ANO1) is a specific marker of the interstitial cells of Cajal (ICC) in the gastrointestinal tract, and are candidate proteins that can function as pacemaker channels. Recently, novel selective ANO1
Seok Choi   +6 more
doaj   +1 more source

Beyond Laparotomy: Multimodal Strategies and Emerging Evidence in Minimally Invasive Management of Gastric Gastrointestinal Stromal Tumors

open access: yesBioMed Research International, Volume 2026, Issue 1, 2026.
Background Gastrointestinal stromal tumor (GIST) is a type of potentially malignant mesenchymal tumor, thought to arise from the interstitial cells of the gut. More than half of all GIST cases occur primarily in the stomach. Currently, radical resection remains the only curative treatment for this disease.
Wenjing Sun, Song Zhao, Li Kun
wiley   +1 more source

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. [PDF]

open access: yes, 2018
OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical ...
Barcellos, Lisa F   +13 more
core   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

open access: yesPhysiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri   +8 more
wiley   +1 more source

TRPC1 regulates calcium-activated chloride channels in salivary gland cells [PDF]

open access: yes, 2015
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion channels such as CaCC to ...
Birnbaumer, Lutz   +2 more
core   +1 more source

Isolation and long‐term culture of primary mouse cholangiocytes that retain biophysical properties and distinct Cl‐conductances: An initial study

open access: yesPhysiological Reports, Volume 14, Issue 2, January 2026.
Mouse cholangiocytes are isolated from bile ducts and cultured in conditioned medium containing ROCK inhibitor. Cells maintain expression of biliary markers & ion channel activity for >50 passages. Abstract Cultures of primary mouse bile duct epithelial cells are a valuable tool to study cholangiocyte secretion and bile formation.
Qin Li   +4 more
wiley   +1 more source

Context-dependent compensation among phosphatidylserine-recognition receptors [PDF]

open access: yes, 2017
Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance.
Han, Claudia Z   +11 more
core   +3 more sources

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