Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources
Physiological Reports, 2020 A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization.
Vladimir V Matchkov +2 more
exaly +2 more sources
Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang +6 more
doaj +2 more sources
ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability [PDF]
The Journal of Headache and PainBackground Endoplasmic reticulum (ER) stress has been implicated in various chronic pain conditions, but its role in trigeminal neuropathic pain (TNP) remains unclear.
Huan-Jun Lu +14 more
doaj +2 more sources
ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions [PDF]
Scientific ReportsAnoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear.
Neha Gupta +10 more
doaj +2 more sources
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]
Frontiers in PharmacologyColorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo +15 more
doaj +2 more sources
Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 [PDF]
International Journal of Molecular Sciences, 2021 Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activated chloride channel (CaCC) overexpressed in various carcinomas.
Yohan Seo +10 more
openaire +2 more sources
Prognostic significance of ANO1 expression in cancers
Medicine, 2021 Abstract Background: Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of ANO1 in cancers. Methods: A total of 1760 patients from 7 eligible studies were included into the analysis.
Congxiao Zhang +5 more
openaire +2 more sources
Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]
PLoS ONE, 2015 The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo +6 more
doaj +1 more source
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. [PDF]
PLoS ONE, 2012 Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and sensitive marker for the diagnosis of gastrointestinal stromal tumors (GIST) and has recently ...
Christian Ruiz +10 more
doaj +1 more source