Results 11 to 20 of about 8,763 (208)

ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells [PDF]

Medicina Oral Patología Oral y Cirugia Bucal, 2013
Objectives: The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC. Study Design: Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues.
Hong, Suling, Li, Yadong, Zhang, Jinsong
core   +5 more sources

The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]

Frontiers in Cardiovascular Medicine
Cardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang, Jia-qi Zhang, Zeng-jin Wen, Xiao-hua Han, Zhen-kang Qiu, Qing-ya Yang, Yue Qiu   +6 more
doaj   +2 more sources

Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+ [PDF]

Nature Communications
ANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+
Wei-Yin Lin, Woo Young Chung, Seonghee Park, Ava Movahed Abtahi, Benjamin Leblanc, Malini Ahuja, Shmuel Muallem   +6 more
doaj   +2 more sources

Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer

International Journal of General Medicine, 2022
Jun Chen,1,* Hongli Wang,2,* Fang Peng,3,* Haiyan Qiao,1 Linfeng Liu,1 Liang Wang,1 Bingbing Shang4 1Laboratory Animal Center, Dalian Medical University, Dalian, 116044, Liaoning Province, People’s Republic of China; 2Cardiology Department ...
Chen J, Wang H, Peng F, Qiao H, Liu L, Wang L, Shang B   +6 more
doaj   +4 more sources

ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases [PDF]

Frontiers in Immunology
Anoctamin 1 (ANO1), also known as TMEM16A, is a multifunctional protein that serves as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed across various tissues, including epithelial cells, smooth muscle cells, and neurons, where ...
Yanghao Hu, Yanghao Hu, Yifei Zhang, Yifei Zhang, Jiali He, Jiali He, Huihuang Rao, Huihuang Rao, Duomi Zhang, Zhisen Shen, Chongchang Zhou   +10 more
doaj   +2 more sources

Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]

Scientific Reports
Calcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang, Kai Zheng, Liu Yang, Liying Liu, Haojian Han, Shuang Chen, Zhanning Qu, Kai Qin, Wansheng Zhang, Feng Hao   +9 more
doaj   +2 more sources

Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]

Frontiers in Immunology
Gastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang, Jie Lin, Hongpan Xu, Yan Zhou, Zhiyi Mu, Ruizhe Shi, Yalei Lv   +6 more
doaj   +2 more sources

Piezo1 in intestinal smooth muscle cells: Emerging perspectives [PDF]

The Journal of Physiology, Volume 604, Issue 1, Page 129-144, 1 January 2026.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +2 more sources

ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability [PDF]

The Journal of Headache and Pain
Background Endoplasmic reticulum (ER) stress has been implicated in various chronic pain conditions, but its role in trigeminal neuropathic pain (TNP) remains unclear.
Huan-Jun Lu, Jia-Wen Shen, Ning-Yi Ren, Nan Hu, Jian-Ke Cen, Meng-Xuan Huang, Si-Yuan Song, Ling-Jie Ma, Xiao-Bo Wu, Xia Li, Mei-Xian Li, Hao Wu, Gyu-Sang Hong, Uhtaek Oh, Yong-Jing Gao   +14 more
doaj   +2 more sources

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions [PDF]

Scientific Reports
Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear.
Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm   +10 more
doaj   +2 more sources