Results 11 to 20 of about 2,978 (169)

Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression [PDF]

Cells, 2020
ANO1, a Ca2+-activated chloride channel, is highly expressed in glioblastoma cells and its surface expression is involved in their migration and invasion. However, the regulation of ANO1 surface expression in glioblastoma cells is largely unknown.
Kyoung Mi Sim, Young-Sun Lee, Hee Jin Kim, Chang-Hoon Cho, Gwan-Su Yi, Myung-Jin Park, Eun Mi Hwang, Jae-Yong Park   +7 more
doaj   +3 more sources

Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer

International Journal of General Medicine, 2022
Jun Chen,1,* Hongli Wang,2,* Fang Peng,3,* Haiyan Qiao,1 Linfeng Liu,1 Liang Wang,1 Bingbing Shang4 1Laboratory Animal Center, Dalian Medical University, Dalian, 116044, Liaoning Province, People’s Republic of China; 2Cardiology Department ...
Chen J, Wang H, Peng F, Qiao H, Liu L, Wang L, Shang B   +6 more
doaj   +4 more sources

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions [PDF]

Scientific Reports
Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear.
Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm   +10 more
doaj   +2 more sources

Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]

Frontiers in Pharmacology
Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo, Yohan Seo, Sion Lee, Raju Das, Sung Baek Jeong, Chul Soon Park, Minuk Kim, Deok Kyu Yoon, Armin Sultana, Kantu Das, Jae-Eon Lee, Yong Hyun Jeon, Phan Thi Thanh Huong, Nguyen Xuan Nhiem, Joohan Woo, Joohan Woo   +15 more
doaj   +2 more sources

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma [PDF]

Scientific Reports
Human papilloma virus-negative head and neck squamous cell carcinoma (HNSCC) frequently harbors 11q13 amplifications. Among the oncogenes at this locus, CCND1 and ANO1 are linked to poor prognosis; however, their individual roles in treatment resistance ...
Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer   +5 more
doaj   +2 more sources

Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 [PDF]

International Journal of Molecular Sciences, 2021
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activated chloride channel (CaCC) overexpressed in various carcinomas.
Yohan Seo, Sung Baek Jeong, Joo Han Woo, Oh-Bin Kwon, Sion Lee, Hye In Oh, Sungwoo Jo, Seon Ju Park, Wan Namkung, Uk Yeol Moon, Sungwoo Lee   +10 more
openaire   +2 more sources

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Frontiers in Bioscience-Landmark, 2022
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei   +7 more
doaj   +1 more source

Prognostic significance of ANO1 expression in cancers

Medicine, 2021
Abstract Background: Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of ANO1 in cancers. Methods: A total of 1760 patients from 7 eligible studies were included into the analysis.
Congxiao Zhang, Haini Li, Jing Gao, Xiaoqing Cui, Shengmei Yang, Zongtao Liu   +5 more
openaire   +2 more sources

Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. [PDF]

PLoS ONE, 2012
Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and sensitive marker for the diagnosis of gastrointestinal stromal tumors (GIST) and has recently ...
Christian Ruiz, Joana Raquel Martins, Florian Rudin, Sandra Schneider, Tanja Dietsche, Claude A Fischer, Luigi Tornillo, Luigi M Terracciano, Rainer Schreiber, Lukas Bubendorf, Karl Kunzelmann   +10 more
doaj   +1 more source

Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]

PLoS ONE, 2015
The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo, Jinhong Park, Minseo Kim, Ho K Lee, Jin-Hee Kim, Jin-Hyun Jeong, Wan Namkung   +6 more
doaj   +1 more source