Abnormal Airway Mucus Secretion Induced by Virus Infection [PDF]
Frontiers in Immunology, 2021 The airway mucus barrier is a primary defensive layer at the airway surface. Mucins are the major structural components of airway mucus that protect the respiratory tract.
Xiao Xiao Tang
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Xenopus: An alternative model system for identifying muco-active agents. [PDF]
PLoS ONE, 2018 The airway epithelium in human plays a central role as the first line of defense against environmental contaminants. Most respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections, disturb normal muco ...
Hyo Jung Sim +5 more
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Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo [PDF]
Journal of Ginseng Research, 2022 Background: Cigarette smoke (CS) is considered a principal cause of chronic obstructive pulmonary disease (COPD) and is associated with mucus hypersecretion and airway inflammation.
Jae-Won Lee +13 more
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Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis [PDF]
Gut MicrobesColonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare +12 more
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Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine [PDF]
Scientific ReportsThe Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion.
Jiraporn Ousingsawat +10 more
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Stressing out over mucus secretion [PDF]
Cell Host & Microbe, 2023 In this issue of Cell Host & Microbe, Naama et al. show that autophagy controls mucus secretion in the colons of mice. They demonstrate that autophagy reduces ER stress in mucus-producing goblet cells to enhance mucus production, which shapes the gut microbial community and protects against colitis.
Grey MJ.
openaire +3 more sources
Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma [PDF]
Journal of Experimental Pharmacology, 2023 Pawin Pongkorpsakol,1,* Chantapol Yimnual,2,* Wilasinee Satianrapapong,3 Nichakorn Worakajit,4 Suchada Kaewin,2 Praphatsorn Saetang,5 Vatcharin Rukachaisirikul,5 Chatchai Muanprasat2 1Princess Srisavangavadhana College of Medicine, Chulabhorn ...
Pongkorpsakol P +7 more
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Coordinated regulation of colonic fluid and mucus secretion [PDF]
Frontiers in PharmacologyThe human colon, unlike the small intestine which is relatively sterile, contains a diverse microbiome which contributes to host metabolism. The luminal environment is constantly changing and responds to epithelial absorption and secretion which occurs ...
Alan W. Baird
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Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic InflammationSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms.
Rainelli Koumangoye +3 more
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CD147 increases mucus secretion induced by cigarette smoke in COPD [PDF]
BMC Pulmonary Medicine, 2019 Background CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COPD), which results in severe airway
Qiao Yu +3 more
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