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Current Biology, 2021 Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades. As a barrier, it lubricates surfaces, protects our cells from physical stress, and selectively allows the passage of nutrients while clearing out ...
McShane, Abigail +7 more
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Stingray epidermal microbiomes are species-specific with local adaptations
Frontiers in Microbiology, 2023 Marine host-associated microbiomes are affected by a combination of species-specific (e.g., host ancestry, genotype) and habitat-specific features (e.g., environmental physiochemistry and microbial biogeography).
Emma N. Kerr +11 more
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Permeability Assessment of a High-Throughput Mucosal Platform
Pharmaceutics, 2023 Permeability across cellular membranes is a key factor that influences absorption and distribution. Before absorption, many drugs must pass through the mucus barrier that covers all the wet surfaces of the human body.
Cosmin Butnarasu +4 more
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Biomedicines, 2023 (1) Background: We have previously shown that sputum rheology can discriminate between patients with COPD and other muco-obstructive lung diseases, and that it is correlated with mucin content and sputum eosinophilia.
Jeremy Charriot +10 more
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The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
Frontiers in Medicine, 2022 Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants.
Youra Kang +3 more
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Mucus, Microbiomes and Pulmonary Disease
Biomedicines, 2021 The respiratory tract harbors a stable and diverse microbial population within an extracellular mucus layer. Mucus provides a formidable defense against infection and maintaining healthy mucus is essential to normal pulmonary physiology, promoting immune
Oliver W. Meldrum, Sanjay H. Chotirmall
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Frontiers in Physiology, 2022 Background: Airway mucus provides important protective functions in health and abnormal viscoelasticity is a hallmark of muco-obstructive lung diseases such as cystic fibrosis (CF).
Mirjam Völler +16 more
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Microorganisms, 2020 Amoebic gill disease (AGD) causes poor performance and death in salmonids. Mucins are mainly comprised by carbohydrates and are main components of the mucus covering the gill.
John Benktander +10 more
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Fishes, 2022 Continuous photoperiod is extensively used in fish farming, to regulate the reproductive cycle, despite evidence suggesting that artificial photoperiods can act as a stressor and impair the immune system.
Ariel Valenzuela +6 more
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Viruses, 2022 Respiratory pathogens can be spread though the transmission of aerosolised expiratory secretions in the form of droplets or particulates. Understanding the fundamental aerosol parameters that govern how such pathogens survive whilst airborne is essential
Robert W. Alexander +12 more
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