Results 1 to 10 of about 654,486 (255)

Human airway tuft cells influence the mucociliary clearance through cholinergic signalling [PDF]

Respiratory Research, 2023
Background Airway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies described a chemosensory cell population, which includes tuft cells, by a distinct gene transcription ...
Monika I. Hollenhorst, Thomas Husnik, Malin Zylka, Nele Duda, Veit Flockerzi, Thomas Tschernig, Stephan Maxeiner, Gabriela Krasteva-Christ   +7 more
doaj   +3 more sources

Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread [PDF]

Nature Communications
SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate viral spread at
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope   +6 more
doaj   +3 more sources

Structure and function relationships of mucociliary clearance in human and rat airways [PDF]

Nature Communications
Mucociliary clearance is a vital defense mechanism of the human airways, protecting against harmful particles and infections. When this process fails, it contributes to respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma ...
Doris Roth, Ayşe Tuğçe Şahin, Feng Ling, Niels Tepho, Christiana N. Senger, Erik J. Quiroz, Ben A. Calvert, Anne M. van der Does, Tankut G. Güney, Sarah Glasl, Annemarie van Schadewijk, Laura von Schledorn, Ruth Olmer, Eva Kanso, Janna C. Nawroth, Amy L. Ryan   +15 more
doaj   +3 more sources

Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis. [PDF]

J Cyst Fibros, 2023
Background: The cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor/tezacaftor/ivacaftor (E/T/I) is highly effective clinically for those with at least one F508del-CFTR allele.
Donaldson SH, Corcoran TE, Pilewski JM, Mogayzel P, Laube BL, Boitet ER, Harris ES, Ceppe A, Edwards LJ, Zeman K, Wu J, Esther CR, Nichols DP, Bennett WD, Rowe SM.   +14 more
europepmc   +2 more sources

Aging Diminishes Mucociliary Clearance of the Lung. [PDF]

Adv Geriatr Med Res, 2022
Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes.
Bailey KL.
europepmc   +2 more sources

The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response. [PDF]

J Clin Invest, 2023
Pathogens and inflammatory conditions rapidly induce the expression of immune-responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate decarboxylase (ACOD1) that produces the immunomodulatory metabolite itaconate (ITA). In addition
Zeng YR, Song JB, Wang D, Huang ZX, Zhang C, Sun YP, Shu G, Xiong Y, Guan KL, Ye D, Wang P.   +10 more
europepmc   +2 more sources

A quantitative interspecies comparison of the respiratory mucociliary clearance mechanism. [PDF]

Eur Biophys J, 2022
Collectively coordinated ciliary activity propels the airway mucus, which lines the luminal surface of the vertebrate respiratory system, in cranial direction. Our contemporary understanding on how the quantitative characteristics of the metachronal wave
Burn A, Schneiter M, Ryser M, Gehr P, Rička J, Frenz M.   +5 more
europepmc   +2 more sources

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides

Immunity, 2020
Mucociliary clearance through coordinated ciliary beating is a major innate defense removing pathogens from the lower airways, but the pathogen sensing and downstream signaling mechanisms remain unclear.
Shuya Liu, Jochen Klein, Thomas Timm
exaly   +2 more sources

Pulmonary radioaerosol mucociliary clearance assessment: searching for genotype-specific differences and potential as an outcome measure in primary ciliary dyskinesia [PDF]

ERJ Open Research, 2023
Background Pulmonary radioaerosol mucociliary clearance (PRMC) is a reliable method for assessing in vivo whole lung mucociliary clearance and has been used at the Danish PCD Centre as a supplementary diagnostic test for primary ciliary dyskinesia (PCD ...
June K. Marthin, Mathias G. Holgersen, Kim G. Nielsen, Jann Mortensen   +3 more
doaj   +2 more sources

The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation

Clinics, 2016
OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (
Daniela Mitiyo Odagiri Utiyama, Carolina Tieko Yoshida, Danielle Miyuki Goto, Tômas de Santana Carvalho, Ubiratan de Paula Santos, Andreas Rembert Koczulla, Paulo Hilário Nascimento Saldiva, Naomi Kondo Nakagawa   +7 more
doaj   +2 more sources