Results 1 to 10 of about 434,754 (278)

Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread [PDF]

Nature Communications
SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate viral spread at
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope   +6 more
doaj   +3 more sources

Structure and function relationships of mucociliary clearance in human and rat airways [PDF]

Nature Communications
Mucociliary clearance is a vital defense mechanism of the human airways, protecting against harmful particles and infections. When this process fails, it contributes to respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma ...
Doris Roth, Ayşe Tuğçe Şahin, Feng Ling, Niels Tepho, Christiana N. Senger, Erik J. Quiroz, Ben A. Calvert, Anne M. van der Does, Tankut G. Güney, Sarah Glasl, Annemarie van Schadewijk, Laura von Schledorn, Ruth Olmer, Eva Kanso, Janna C. Nawroth, Amy L. Ryan   +15 more
doaj   +3 more sources

Nontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis [PDF]

Microorganisms
Nontuberculous mycobacteria (NTM) are environmental and ubiquitous, but only a few species are associated with disease, often presented as nodular/bronchiectatic or cavitary pulmonary forms. Bronchiectasis, airways dilatations characterized by chronic productive cough, is the main presentation of NTM pulmonary disease. The current Cole’s vicious circle
Miriam Retuerto-Guerrero, Ramiro López-Medrano, Elizabeth de Freitas-González, Octavio Miguel Rivero-Lezcano   +3 more
doaj   +5 more sources

Cilia and Mucociliary Clearance [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous ...
Ximena M, Bustamante-Marin, Lawrence E, Ostrowski   +1 more
openaire   +3 more sources

Human airway tuft cells influence the mucociliary clearance through cholinergic signalling [PDF]

Respiratory Research, 2023
Background Airway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies described a chemosensory cell population, which includes tuft cells, by a distinct gene transcription ...
Monika I. Hollenhorst, Thomas Husnik, Malin Zylka, Nele Duda, Veit Flockerzi, Thomas Tschernig, Stephan Maxeiner, Gabriela Krasteva-Christ   +7 more
doaj   +2 more sources

Impact of smoking on nasal mucociliary clearance time in Kano metropolis, Nigeria [PDF]

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2023
Background Mucociliary clearance is an important defense mechanism in human upper and lower respiratory airways. Impairment of this process by certain conditions such as cigarette smoking can predispose to chronic infection and neoplasm of the nose and ...
Ahmad Mahmud, Abubakar D. Salisu, Emmanuel S. Kolo, Muhammad G. Hasheem, Nafisatu Bello‐Muhammad, Ahmad R. Tukur, Yasir J. Nuhu, Rabiu I. Jalo   +7 more
doaj   +2 more sources

Pulmonary radioaerosol mucociliary clearance assessment: searching for genotype-specific differences and potential as an outcome measure in primary ciliary dyskinesia [PDF]

ERJ Open Research, 2023
Background Pulmonary radioaerosol mucociliary clearance (PRMC) is a reliable method for assessing in vivo whole lung mucociliary clearance and has been used at the Danish PCD Centre as a supplementary diagnostic test for primary ciliary dyskinesia (PCD ...
June K. Marthin, Mathias G. Holgersen, Kim G. Nielsen, Jann Mortensen   +3 more
doaj   +2 more sources

Mucociliary Transport Device Construction and Application to Study Mucociliary Clearance [PDF]

Methods Mol Biol, 2023
Well-differentiated air-liquid interface cultures of airway epithelial cells produce and secrete mucus and have abundant cilia that beat in the apical fluid. In cultures, this ciliary beating is not well coordinated or occurs in small focal areas so the resulting mucociliary transport (MCT) is only linear over short distances. We present a method which
Sears, Patrick R, Ostrowski, Lawrence E
openaire   +4 more sources

Mucociliary clearance in chronic sinusitis [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 1998
Mucociliary clearance is an important defence mechanism of upper and lower respiratory tracts. Any disturbance in the mechanism leads to stagnation of secretions and secondary infection with prolonged mucociliary clearance time. The present study was undertaken to establish normal mucociliary clearance time in our region and to evaluate its diagnostic ...
S M, Birdi, S, Singh, A, Singh
openaire   +4 more sources

Modelling mucociliary clearance [PDF]

Respiratory Physiology & Neurobiology, 2008
Mathematical modelling of the fluid mechanics of mucociliary clearance (MCC) is reviewed and future challenges for researchers are discussed. The morphology of the bronchial and tracheal airway surface liquid (ASL) and ciliated epithelium are briefly introduced. The cilia beat cycle, beat frequency and metachronal coordination are described, along with
Smith, D, Gaffney, E, Blake, JR
openaire   +4 more sources