Results 21 to 30 of about 434,754 (278)

Effect of lumacaftor-ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis: Results from the PROSPECT MCC sub-study

Journal of Cystic Fibrosis, 2021
CFTR function is required for normal mucociliary clearance (MCC) and cough-assisted clearance (CC). Lumacaftor-ivacaftor is approved for use in people with cystic fibrosis (CF) carrying two copies of F508del-CFTR. In this observational study performed at
S. Donaldson, B. Laube, P. Mogayzel, T. Corcoran, J. Pilewski, A. Ceppe, Jihong Wu, P. Bhambhvani, F. Ratjen, S. Sagel, J. Clancy, S. Rowe, W. Bennett   +12 more
semanticscholar   +1 more source

The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]

, 2016
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie, Devos, Simon, Devreese, Bart   +2 more
core   +4 more sources

Air Pollution and Nasal Mucociliary Clearance Time among Urban and Rural Residents in Two Philippine Communities

Philippine Journal of Otolaryngology Head and Neck Surgery, 2020
Objective: To measure the nasal mucociliary clearance (NMC) time among adults residing in two Philippine communities with different air quality indices using the saccharin and methylene blue test.
Soraya Joson, Joman Laxamana
doaj   +1 more source

Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis. [PDF]

J Cyst Fibros, 2023
Background: The cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor/tezacaftor/ivacaftor (E/T/I) is highly effective clinically for those with at least one F508del-CFTR allele.
Donaldson SH, Corcoran TE, Pilewski JM, Mogayzel P, Laube BL, Boitet ER, Harris ES, Ceppe A, Edwards LJ, Zeman K, Wu J, Esther CR, Nichols DP, Bennett WD, Rowe SM.   +14 more
europepmc   +2 more sources

Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro

Materials Today Bio, 2023
Human lung function is intricately linked to blood flow and breathing cycles, but it remains unknown how these dynamic cues shape human airway epithelial biology.
Janna C. Nawroth, Doris Roth, Annemarie van Schadewijk, Abilash Ravi, Tengku Ibrahim Maulana, Christiana N. Senger, Sander van Riet, Dennis K. Ninaber, Amy M. de Waal, Dorothea Kraft, Pieter S. Hiemstra, Amy L. Ryan, Anne M. van der Does   +12 more
doaj   +1 more source

Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography [PDF]

, 2012
We demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia.
A Crews, AB Lansley, AL Oldenburg, AS Shah, B Kerem, Bradford J. Diephuis, C Azbell, CJ Martens, CJ Martens, CS Rogers, D Huang, D Huang, D Li, EN Worthington, Eric J. Sorscher, Eric J. Wilsterman, F Van Goor, F Van Goor, G Di Benedetto, G Häusler, Grace H. Houser, Gregory Dierksen, Guillermo J. Tearney, H Matsui, H Matsui, HJ Cho, JF de Boer, JH Chen, JR Riordan, Kengyeh K. Chu, L Liu, Linbo Liu, MA Chilvers, MA Choma, MA Sleigh, Marina Mazur, Michael Myerburg, MJ Sanderson, MJ Sanderson, MJ Sanderson, MJ Sanderson, NS Joo, NS Joo, PJ Barnes, R Leitgeb, R Tarran, R Tarran, RG Michel, S Hayashi, S Jayaraman, SH Donaldson, SH Donaldson, SK Lai, SM Rowe, SM Rowe, ST Ballard, ST Ballard, Steven M. Rowe, Suresh Shastry, Susan E. Birket, Suzanne Byan-Parker, William E. Grizzle, WM Foster, Yao Li   +63 more
core   +11 more sources

The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study. [PDF]

Clin Physiol Funct Imaging
Abstract Background Inhaled saline may improve mucus transport in respiratory diseases, for example, cystic fibrosis. This randomised, placebo‐controlled, crossover study examined the effect of inhaled dry NaCl on mucociliary clearance in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty‐five patients with GOLD stage I‐III COPD
Thomsen RS, Mikkelsen C, Olsen NE, Einarsdóttir HS, Attauabi M, Berg RMG, Harboe H, Mortensen J.   +7 more
europepmc   +2 more sources

ENERGY PROCESSES OF MUCOCILIARY CLEARANCE [PDF]

Journal of IMAB, 2019
The main objective of the paper is to describe in detail the physiology and pathophysiology of the mucociliary transport system. Mucociliary clearance (MCC) is a principal component of the respiratory tract. As an important defence mechanism, it provides
Vadim S. Isachenko, Lubov V. Minaeva, Vladimir V. Dvorianchikov, Vasiliy G. Mironov, Ksenia V. Vinichenko, Andrey V. Shafigulin, Iliyan Doykov, Dilyana Vicheva   +7 more
doaj   +1 more source

Olfactory evaluation in obstructive sleep apnoea patients [PDF]

, 2018
The sense of smell has a high impact on the quality of life. The aim of the present study was to investigate olfactory dysfunction in patients with obstructive sleep apnoea syndrome (OSAS) and correlate the severity of disease with olfactory dysfunction.
ANGELETTI, DILETTA, CIOFALO, Andrea, de Vincentiis, M., Iannella, G., Magliulo, Giuseppe, Manno, A., PASQUARIELLO, BENEDETTA, Polimeni, A.   +7 more
core   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source