Results 11 to 20 of about 434,754 (278)
Numerical and experimental investigation of mucociliary clearance breakdown in cystic fibrosis [PDF]
Journal of Biomechanics, 2017 The human tracheobronchial tree surface is covered with mucus. A healthy mucus is a heterogeneous material flowing toward the esophagus and a major defense actor against local pathogen proliferation and pollutant deposition. An alteration of mucus or its
Anne-Archard, Dominique +4 more
core +5 more sources
Clinics, 2016 OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (
Daniela Mitiyo Odagiri Utiyama +7 more
doaj +2 more sources
Airway Epithelial Differentiation and Mucociliary Clearance [PDF]
Annals of the American Thoracic Society, 2018 Abstract The lung is continuously exposed to particles, toxicants, and microbial pathogens that are cleared by a complex mechanical, innate, and acquired immune system. Mucociliary clearance, mediated by the actions of diverse conducting airway and submucosal gland epithelial cells, plays a critical role in a multilayered defense ...
J. Whitsett
openaire +3 more sources
Mathematical Modeling of Mucociliary Clearance: A Mini-Review
Cells, 2019 Mucociliary clearance is an important innate host defense of the mammalian respiratory system, as it traps foreign substances, including pollutants, pathogens, and allergens, and transports them out of the airway.
Ling Xu, Yi Jiang
doaj +2 more sources
Aging Diminishes Mucociliary Clearance of the Lung. [PDF]
Adv Geriatr Med Res, 2022 Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes.
Bailey KL.
europepmc +2 more sources
Regional Differences in Mucociliary Clearance in the Upper and Lower Airways. [PDF]
Front Physiol, 2022 As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must be removed to keep the lower airways sterile.
Rogers TD +7 more
europepmc +2 more sources
A quantitative interspecies comparison of the respiratory mucociliary clearance mechanism. [PDF]
Eur Biophys J, 2022 Collectively coordinated ciliary activity propels the airway mucus, which lines the luminal surface of the vertebrate respiratory system, in cranial direction. Our contemporary understanding on how the quantitative characteristics of the metachronal wave
Burn A +5 more
europepmc +2 more sources
Nature Communications, 2021 Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human ...
R. Robinot +24 more
semanticscholar +1 more source
Prediction of nasal spray drug absorption influenced by mucociliary clearance
PLoS ONE, 2021 Evaluation of nasal spray drug absorption has been challenging because deposited particles are consistently transported away by mucociliary clearance during diffusing through the mucus layer.
Y. Shang +5 more
semanticscholar +1 more source
Mutations in TP73 cause impaired mucociliary clearance and lissencephaly.
American Journal of Human Genetics, 2021 TP73 belongs to the TP53 family of transcription factors and has therefore been well studied in cancer research. Studies in mice, however, have revealed non-oncogenic activities related to multiciliogenesis. Utilizing whole-exome sequencing analysis in a
J. Wallmeier +18 more
semanticscholar +1 more source