Results 11 to 20 of about 386,514 (347)

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction [PDF]

Journal of Clinical Investigation, 2018
Castro, Mario, et al,, Gierada, David S
core   +3 more sources

Intestinal mucus and their glycans: A habitat for thriving microbiota.

Cell Host and Microbe, 2023
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to bacteria and an outer mucus layer that is expanded to allow microbiota colonization.
A. Luis, G. Hansson
semanticscholar   +1 more source

Intestinal mucus components and secretion mechanisms: what we do and do not know

Experimental and Molecular Medicine, 2023
Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs.
Chunyan Song, Zhenglong Chai, Si Chen, Hui Zhang, Xiaohong Zhang, Yuping Zhou   +5 more
semanticscholar   +1 more source

Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease.

Journal of the American Medical Association (JAMA), 2023
Importance Airway mucus plugs are common in patients with chronic obstructive pulmonary disease (COPD); however, the association of airway mucus plugging and mortality in patients with COPD is unknown.
A. Díaz, J. Orejas, S. Grumley, H. Nath, Wei Wang, W. Dolliver, A. Yen, S. Kligerman, K. Jacobs, Padma Manapragada, M. Abozeed, M. U. Aziz, M. Zahid, Asmaa N Ahmed, N. Terry, Rúben San José Estépar, V. Kim, B. Make, M. Han, S. Sonavane, G. Washko, M. Cho, Raúl San José Estépar   +22 more
semanticscholar   +1 more source

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Gut, 2020
The gastrointestinal tract is often considered as a key organ involved in the digestion of food and providing nutrients to the body for proper maintenance. However, this system is composed of organs that are extremely complex.
P. Paone, Patrice D Cani
semanticscholar   +1 more source

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers.

International journal of pharmaceutics, 2023
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their removal via mucociliary clearance (MCC).
R. Pangeni, Tuo Meng, Sagun Poudel, Divya Sharma, Hallie Hutsell, Jonathan Ma, B. Rubin, Worth Longest, M. Hindle, Qingguo Xu   +9 more
semanticscholar   +1 more source

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.

NEJM Evidence, 2023
Tezepelumab and Mucus Plugs in Patients with AsthmaMucus plugs in airways of asthma patients are associated with airway obstruction and the activity of inflammatory cytokines.
L. Nordenmark, A. Hellqvist, Claire L. Emson, S. Diver, C. Porsbjerg, J. Griffiths, John D Newell, S. Peterson, Beata Pawlikowska, J. R. Parnes, A. Megally, G. Colice, Christopher E. Brightling   +12 more
semanticscholar   +1 more source

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

Journal of Nanobiotechnology, 2022
Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence.
D. Subramanian, R. Langer, G. Traverso
semanticscholar   +1 more source

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Science, 2021
Goblet cell diversity An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström et al.
Elisabeth E. L. Nyström, B. Martinez-Abad, L. Arike, G. Birchenough, Eric B. Nonnecke, P. A. Castillo, Frida Svensson, C. Bevins, G. Hansson, M. Johansson   +9 more
semanticscholar   +1 more source

Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment

Mediators of Inflammation, 2023
Most patients diagnosed with chronic obstructive pulmonary disease (COPD) present with hallmark features of airway mucus hypersecretion, including cough and expectoration.
B. Shah, Bivek Singh, Yukun Wang, Shuanshuan Xie, Chang-Feng Wang   +4 more
semanticscholar   +1 more source