Revista Portuguesa de Pneumologia, 2008 Resumo: As sociedades cientÃficas respiratórias europeia e americana (ERS e ATS) constituÃram um grupo de trabalho sobre a âAvaliação dos resultados nos ensaios clÃnicos na DPOC: da função pulmonar aos marcadores biológicosâ para informar a ...
M. Cazzola +3 more
doaj +1 more source
Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]
, 2016 BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K +14 more
core +2 more sources
Does the BCL-2 family member BIK control lung carcinogenesis?
Molecular & Cellular Oncology, 2018 Hyperplastic airway epithelial cells may be the cause for increased risk for lung cancer in patients with chronic lung diseases. The B-cell lymphoma 2 (Bcl-2) family member, Bcl-2-interacting killer (BIK), triggers cell death specifically in these ...
Yohannes A. Mebratu, Yohannes Tesfaigzi
doaj +1 more source
Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) [PDF]
, 2014 Objectives: The optimal method of identifying people with chronic obstructive pulmonary disease (COPD) from electronic primary care records is not known. We assessed the accuracy of different approaches using the Clinical Practice Research Datalink, a UK
Davis, K +7 more
core +2 more sources
The UK quality and outcomes framework pay-for-performance scheme and spirometry: rewarding quality or just quantity? A cross-sectional study in Rotherham, UK [PDF]
, 2009 Background: Accurate spirometry is important in the management of COPD. The UK Quality and Outcomes Framework pay-for-performance scheme for general practitioners includes spirometry related indicators within its COPD domain. It is not known whether high
A Downing +11 more
core +4 more sources
Asthma Symptoms Do not Predict Spirometry
Canadian Respiratory Journal, 2007 BACKGROUND: Asthma is a disease characterized by variable airflow obstruction, but the measurement of airflow is often omitted in the process of diagnosis and management of the disease.
Robert L Cowie +2 more
doaj +1 more source
The Laboratory-Based Intermountain Validated Exacerbation (LIVE) Score Identifies Chronic Obstructive Pulmonary Disease Patients at High Mortality Risk. [PDF]
, 2018 Background: Identifying COPD patients at high risk for mortality or healthcare utilization remains a challenge. A robust system for identifying high-risk COPD patients using Electronic Health Record (EHR) data would empower targeting interventions aimed ...
Arjomandi, Mehrdad +9 more
core +1 more source
Heme metabolism genes Downregulated in COPD Cachexia. [PDF]
, 2020 IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes.
Agusti, Alvar +21 more
core +3 more sources
Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? [PDF]
, 2017 Differentiating between chronic obstructive pulmonary disease (COPD) patients with normal (PiMM) or deficient (PiZZ) genetic variants of alpha-1 antitrypsin (A1AT) is important not only for understanding the pathobiology of disease progression but also ...
Carleo, Alfonso +7 more
core +2 more sources
Telemonitoring of daily activity and symptom behavior in patients with COPD [PDF]
, 2012 Objectives. This study investigated the activity behavior of patients with COPD in detail compared to asymptomatic controls, and the relationship between subjective and objective activities (awareness), and readiness to change activity behavior. Methods.
Hermens, H.J. +5 more
core +3 more sources