Results 31 to 40 of about 331,890 (216)
European Respiratory Review, 2015 Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence ...
Bartolome R. Celli +53 more
doaj +1 more source
What is a COPD-Like Spirometry Test Result in Resource Constrained Settings? [PDF]
, 2019 The diagnosis of chronic obstructive pulmonary disease (COPD), a global health problem, is challenging in resource-constrained settings. Spirometry with an obstructive pattern after the administration of bronchodilators is required for the diagnosis of ...
Miranda, J. Jaime +5 more
core +1 more source
Does the BCL-2 family member BIK control lung carcinogenesis?
Molecular & Cellular Oncology, 2018 Hyperplastic airway epithelial cells may be the cause for increased risk for lung cancer in patients with chronic lung diseases. The B-cell lymphoma 2 (Bcl-2) family member, Bcl-2-interacting killer (BIK), triggers cell death specifically in these ...
Yohannes A. Mebratu, Yohannes Tesfaigzi
doaj +1 more source
Beyond FEV1 in COPD: a review of patient-reported outcomes and their measurement [PDF]
, 2012 : Patients with chronic obstructive pulmonary disease (COPD) present with a variety of symptoms and pathological consequences. Although primarily viewed as a respiratory disease, COPD has both pulmonary and extrapulmonary effects, which have an impact on
van der Molen, T +7 more
core +1 more source
Asthma Symptoms Do not Predict Spirometry
Canadian Respiratory Journal, 2007 BACKGROUND: Asthma is a disease characterized by variable airflow obstruction, but the measurement of airflow is often omitted in the process of diagnosis and management of the disease.
Robert L Cowie +2 more
doaj +1 more source
Creating scenarios of the impact of copd and their relationship to copd assessment test (CAT (TM)) scores [PDF]
, 2011 Background: The COPD Assessment Test (CAT™) is a new short health status measure for routine use. New questionnaires require reference points so that users can understand the scores; descriptive scenarios are one way of doing this.
Chen, WH +8 more
core +2 more sources
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF
Scientific Reports, 2021 The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF.
Susan Monkley +16 more
doaj +1 more source
European Respiratory Review, 2019 Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators
Raja Chandra Chakinala +4 more
openaire +3 more sources
Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD:implication for COPD-associated neuropathogenesis [PDF]
, 2014 The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological ...
Hongwei Yao +20 more
core +1 more source
F1000Research, 2017 Novel pharmacotherapies introduce additional options to providers and patients in how to best treat chronic obstructive pulmonary disease (COPD). Emerging data question the role of inhaled corticosteroids in COPD treatment, particularly as combination ...
Sharon R Rosenberg, Ravi Kalhan
doaj +1 more source