Results 41 to 50 of about 331,890 (216)

Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]

, 2014
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Musuamba, F.T., O. Della Pasqua, H. J. Maas, A. Facius, Della Pasqua, O., Della Pasqua, O, Yang, S., M. Danhof, D. Teutonico, Facius, A, Musuamba, FT, Teutonico, D, Yang, S, Facius, A., Danhof, M., S. Yang, Teutonico, D., Maas, H.J., Maas, HJ, Danhof, M, F. T. Musuamba   +20 more
core   +1 more source

Assessment and Management of Patients with Chronic Cough by Certified Respiratory Educators: A Randomized Controlled Trial

Canadian Respiratory Journal, 2009
BACKGROUND: The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most common reasons for consultation with a respirologist. In the present study,
Stephen K Field, Diane P Conley, Amin M Thawer, Richard Leigh, Robert L Cowie   +4 more
doaj   +1 more source

A study to assess COPD Symptom-based Management and to Optimise treatment Strategy in Japan (COSMOS-J) based on GOLD 2011 [PDF]

, 2013
Background and objective: The Global initiative for chronic Obstructive Lung Disease(GOLD) Committee has proposed a chronic obstructive pulmonary disease (COPD) assessment framework focused on symptoms and on exacerbation risk. This study will evaluate a
Hitosugi, H, James, M, Hagan, G, Kobayashi, A, Kato, M, Jones, PW, Betsuyaku, T, Fujimoto, K   +7 more
core   +1 more source

The relationship between the COPD Assessment Test score and airflow limitation in Japan in patients aged over 40 years with a smoking history. [PDF]

, 2014
BACKGROUND: A large number of chronic obstructive pulmonary disease (COPD) patients in Japan remain undiagnosed, primarily due to the underuse of spirometry. Two studies were conducted to see whether the COPD Assessment Test (CAT) in primary care has the
Hagan, G, Nakano, Y, Jones, P, Onishi, K, Yoshimoto, D   +4 more
core   +1 more source

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins [PDF]

, 2021
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP).
Heijink, Irene H, Woldhuis, Roy R; id_orcid, Timens, Wim; id_orcid, de Vries, Maaike, van den Berge, Maarten, Brandsma, Corry-Anke; id_orcid, Brandsma, Corry-Anke, Oliver, Brian G G, Woldhuis, Roy R, van den Berge, Maarten; id_orcid, Timens, Wim   +10 more
core   +2 more sources

NO: COPD and beyond [PDF]

Thorax, 1997
Background. Inhalation of nitric oxide (NO) causes selective pulmonary vasodilation and improves arterial oxygenation in acute respiratory distress syndrome. But some patients do not respond or gas exchange worsens when inhaling NO. We hypothesised that this detrimental effect might be related to the reversion of hypoxic vasconstriction in those ...
A T, Jones, T W, Evans
openaire   +2 more sources

The COPD Pipeline

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2009
Smoking Cessation. Nabi Biopharmaceuticals has received a NIDA grant of $4+ million in partial support of the next and, one hopes, final phases of a possible nicotine conjugate vaccine.
openaire   +3 more sources

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source

AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers

Respiratory Research, 2019
Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signaling is a key pathway in the pathophysiology of
Alen Faiz, Maarten van den Berge, Cornelis J. Vermeulen, Nick H. T. ten Hacken, Victor Guryev, Simon D. Pouwels   +5 more
doaj   +1 more source

Validation of new predictors of mortality and BODE index variants in patients with COPD at moderate altitude

ERJ Open Research
Background COPD ranks as the third leading global cause of mortality. Despite the widespread use of the BODE index and its variants for mortality prediction, their accuracy may be affected by factors like ethnicity, altitude and regional disparities ...
Robinson Robles-Hernández, Gustavo I. Centeno-Saenz, Alejandra Ramírez-Venegas, Ireri Thirion-Romero, Rafael Hernández-Zenteno, Sandra P. Guinto-Ramírez, María C. Maya-García, Diana Villegas-Trejo, Francisco Montiel-López, Lila M. Cordero-Silis, Rogelio Pérez-Padilla   +10 more
doaj   +1 more source