Results 21 to 30 of about 429,594 (295)

Current concepts on the role of inflammation in COPD and lung cancer [PDF]

, 2009
Chronic obstructive pulmonary disease (COPD) and lung cancer are leading cause of death, and both are associated with cigarette smoke exposure. It has been shown that 50–70% of patients diagnosed with lung cancer suffer from COPD, and reduced lung ...
Abdel-Aziz, Adenuga, Barnes, Bonomi, Brock, Campisi, Cao, Chen, Edirisinghe, Fong, Gebel, Goswami, Gozuacik, Gridelli, Hogg, Hogg, Hongwei Yao, Houghton, Irfan Rahman, Ito, Kamlah, Kasahara, Lee, Liu, Liu, Mannino, Marwick, Michaud, Moghaddam, Morris, Nozik-Grayck, Parimon, Pilette, Rajendrasozhan, Reiman, Rossi, Saitoh, Scherz-Shouval, Senderowicz, Siafakas, Sun, Takizawa, Tomita, Tsuji, van der Strate, van Houwelingen, Voelkel, Yamamoto, Yang, Yang, Yao, Yue   +51 more
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Addiction to tobacco smoking and vaping

Revista de Investigación Clínica, 2023
The tobacco epidemic has been one of the biggest public health threats, and smoking is one of the world’s largest preventable causes of premature death. An estimated 15.4% of all deaths in the world are attributable to tobacco smoking. The present review
Andrea Hernández-Pérez, Leonor García-Gómez, Robinson Robles-Hernández, Ireri Thirión-Romero, Jennifer Osio-Echánove, Sebastián Rodríguez-Llamazares, Ruben Baler, Rogelio Pérez-Padilla   +7 more
doaj   +1 more source

Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]

, 2016
Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya, Iguchi, Masaharu, Ishizaki, Takeshi, Kadowaki, Maiko, Kato, Ryo, Mizuno, Shiro, Nakagawa, Ken, Oikawa, Taku, Osanai, Kazuhiro, Shiozaki, Kohei, Toga, Hirohisa, Voelkel, Norbert F   +11 more
core   +2 more sources

Pulmonary artery stiffness in chronic obstructive pulmonary disease (copd) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study [PDF]

, 2018
Purpose: Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be
Balte, Pallavi, Barr, R. Graham, Bluemke, David A., Carr, James, Dashnaw, Stephen, Gomes, Antoinette S., Hoffman, Eric A., Kawut, Steven M., Lima, Joao A.C., Liu, Chia-Ying, McAllister, David A., Parikh, Megha, Poor, Hooman D.   +12 more
core   +1 more source

Prevalence of asthma and COPD and blood eosinophil count in a middle-aged Belgian population [PDF]

, 2019
Various phenotypes exist in asthma and Chronic Obstructive Pulmonary Disease (COPD). These are important to identify in order to guide treatment decisions.
Brusselle, Guy, De Buyzere, Marc, Lahousse, Lies, Rietzschel, Ernst, Wijnant, Sara   +4 more
core   +1 more source

Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote disease ...
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux   +7 more
doaj   +1 more source

Testing for alpha-1 antitrypsin in COPD in outpatient respiratory clinics in Spain: A multilevel, cross-sectional analysis of the EPOCONSUL study [PDF]

, 2018
Background Alpha-1 antitrypsin deficiency (AATD) is the most common hereditary disorder in adults, but is under-recognized. In Spain, the number of patients diagnosed with AATD is much lower than expected according to epidemiologic studies.
Alcázar Navarrete, Bernardino, Calle Rubio, Myriam, López-Campos Bodineau, José Luis, Rodríguez González-Moro, José Miguel, Rodríguez Hermosa, Juan Luis, Soler-Cataluña, Juan J., Soriano, Joan B.   +6 more
core   +1 more source

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

European Respiratory Review, 2015
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence ...
Bartolome R. Celli, Marc Decramer, Jadwiga A. Wedzicha, Kevin C. Wilson, Alvar A. Agustí, Gerard J. Criner, William MacNee, Barry J. Make, Stephen I. Rennard, Robert A. Stockley, Claus Vogelmeier, Antonio Anzueto, David H. Au, Peter J. Barnes, Pierre-Regis Burgel, Peter M. Calverley, Ciro Casanova, Enrico M. Clini, Christopher B. Cooper, Harvey O. Coxson, Daniel J. Dusser, Leonardo M. Fabbri, Bonnie Fahy, Gary T. Ferguson, Andrew Fisher, Monica J. Fletcher, Maurice Hayot, John R. Hurst, Paul W. Jones, Donald A. Mahler, François Maltais, David M. Mannino, Fernando J. Martinez, Marc Miravitlles, Paula M. Meek, Alberto Papi, Klaus F. Rabe, Nicolas Roche, Frank C. Sciurba, Sanjay Sethi, Nikos Siafakas, Don D. Sin, Joan B. Soriano, James K. Stoller, Donald P. Tashkin, Thierry Troosters, Geert M. Verleden, Johny Verschakelen, Jorgen Vestbo, John W. Walsh, George R. Washko, Robert A. Wise, Emiel F.M. Wouters, Richard L. ZuWallack   +53 more
doaj   +1 more source

STOP: an open label crossover trial to study ICS withdrawal in patients with a combination of obesity and low-inflammatory asthma and evaluate its effect on asthma control and quality of life

BMC Pulmonary Medicine, 2022
Background Asthma patients with obesity often have a high disease burden, despite the use of high-dose inhaled corticosteroids (ICS). In contrast to asthmatics with normal weight, the efficacy of ICS in patients with obesity and asthma is often ...
Jan A. Witte, Gert-Jan Braunstahl, Wouter J. B. Blox, Susan C. van ’t Westeinde, Johannes C. C. M. in ’t Veen, Jasper H. Kappen, Elisabeth F. C. van Rossum   +6 more
doaj   +1 more source

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Nature Communications, 2017
Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi   +6 more
doaj   +1 more source