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Muco-Obstructive Lung Diseases

New England Journal of Medicine, 2019
A spectrum of lung diseases that affect the airways, including chronic obstructive pulmonary disease (COPD), cystic fibrosis, primary ciliary dyskinesia, and non–cystic fibrosis bronchiectasis, can be characterized as muco-obstructive diseases. These diseases have the clinical features of cough, sputum production, and episodic exacerbations that are ...
Boyton, RJ, Altmann, DM
semanticscholar   +8 more sources

Diet and Obstructive Lung Diseases [PDF]

Epidemiologic Reviews, 2001
The results presented in this review suggest that the impact of nutrition on obstructive lung disease is most evident for antioxidant vitamins, particularly vitamin C and, to a lesser extent, vitamin E. By decreasing oxidant insults to the lung, antioxidants could modulate the development of chronic lung diseases and lung function decrement ...
I, Romieu, C, Trenga
openaire   +3 more sources

Sleep and Obstructive Lung Diseases [PDF]

Sleep Medicine Clinics, 2008
Asthma and chronic obstructive pulmonary disease (COPD) are common obstructive lung diseases affecting millions of people in the United States. As sleep disorders are also common, it is not surprising that many people with obstructive lung disease also suffer from sleep disorders. However, people with COPD and those with asthma have worse sleep quality
Michael E, Ezzie, Jonathan P, Parsons, John G, Mastronarde   +2 more
openaire   +3 more sources

Airway mucus in infection [PDF]

Frontiers in Physiology
The mucosa of the airways is under a near-constant barrage of contaminants, allergens, and pathogens that can accumulate and cause irritation or infection if not promptly removed.
Caitlin Costello, Caitlin Costello, Susan Birket, Susan Birket   +3 more
doaj   +2 more sources

Qualitative and quantitative evaluation of computed tomography changes in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor: a retrospective observational study

Frontiers in Pharmacology, 2023
Introduction: The availability of highly effective triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapy with elexacaftor–tezacaftor–ivacaftor (ETI) has improved pulmonary outcomes and quality of life of people ...
Sabine Dettmer, Sabine Dettmer, Oliver Weinheimer, Oliver Weinheimer, Annette Sauer-Heilborn, Oliver Lammers, Mark O. Wielpütz, Mark O. Wielpütz, Jan Fuge, Jan Fuge, Tobias Welte, Tobias Welte, Frank Wacker, Frank Wacker, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen   +16 more
doaj   +1 more source

Interleukin‐17A and interleukin‐22 production by conventional and non‐conventional lymphocytes in three different end‐stage lung diseases

Clinical & Translational Immunology, 2022
Objectives The contribution of adaptive vs. innate lymphocytes to IL‐17A and IL‐22 secretion at the end stage of chronic lung diseases remains largely unexplored. In order to uncover tissue‐ and disease‐specific secretion patterns, we compared production
Melanie Albrecht, Olga Halle, Svenja Gaedcke, Sophia T Pallenberg, Julia Camargo Neumann, Marius Witt, Johanna Roediger, Marina Schumacher, Adan Chari Jirmo, Gregor Warnecke, Danny Jonigk, Peter Braubach, David DeLuca, Gesine Hansen, Anna‐Maria Dittrich   +14 more
doaj   +1 more source

Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype

Cells, 2023
Whole-exome sequencing has expedited the diagnostic work-up of primary ciliary dyskinesia (PCD), when used in addition to clinical phenotype and nasal nitric oxide. However, it reveals variants of uncertain significance (VUS) in established PCD genes or (
Ben O. Staar, Jan Hegermann, Bernd Auber, Raphael Ewen, Sandra von Hardenberg, Ruth Olmer, Isabell Pink, Jessica Rademacher, Martin Wetzke, Felix C. Ringshausen   +9 more
doaj   +1 more source

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients

Biomolecules, 2022
Alpha-1-Antitrypsin (AAT) is a protein of the SERPINA1 gene. A single amino acid mutation (Lys342Glu) results in an expression of misfolded Z-AAT protein, which has a high propensity to intra- and extra-cellular polymerization.
Annelot D. Sark, Malin Fromme, Beata Olejnicka, Tobias Welte, Pavel Strnad, Sabina Janciauskiene, Jan Stolk   +6 more
doaj   +1 more source

Spirometric and anthropometric improvements in response to elexacaftor/tezacaftor/ivacaftor depending on age and lung disease severity

Frontiers in Pharmacology, 2023
Introduction: Triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) was introduced in August 2020 in Germany for people with CF (pwCF) ≥12 years (yrs.) of age and in ...
Katharina Schütz, Katharina Schütz, Sophia Theres Pallenberg, Sophia Theres Pallenberg, Julia Kontsendorn, David DeLuca, David DeLuca, Cinja Sukdolak, Cinja Sukdolak, Rebecca Minso, Rebecca Minso, Tina Büttner, Tina Büttner, Tina Büttner, Martin Wetzke, Christian Dopfer, Annette Sauer-Heilborn, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Burkhard Tümmler, Gesine Hansen, Gesine Hansen, Anna-Maria Dittrich, Anna-Maria Dittrich   +26 more
doaj   +1 more source

Getting it Right in Obstructive Lung Disease

Journal of Clinical Medicine, 2023
Chronic hypercapnic respiratory failure in obstructive lung diseases may benefit from nocturnal Home non-invasive ventilation (HNIV). It has been shown that in patients with persistence of hypercapnia after an acute episode of chronic obstructive pulmonary disease (COPD) exacerbation requiring mechanical ventilation, HNIV may improve the risk for new ...
Carlucci, Annalisa, Fusar Poli, Barbara
openaire   +2 more sources