Results 11 to 20 of about 184,952 (311)

Multifaceted Roles of Ferroptosis in Lung Diseases

Frontiers in Molecular Biosciences, 2022
Ferroptosis is a distinct type of programmed cell death (PCD) that depends on iron and is characterized by the accumulation of intracellular iron, exhaustion of glutathione, deactivation of glutathione peroxidase, and promotion of lipid peroxidation ...
Yi Li, Yi Li, Yi Li, Ying Yang, Ying Yang, Yongfeng Yang, Yongfeng Yang, Yongfeng Yang   +7 more
doaj   +1 more source

Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease [PDF]

, 2010
Background: there is accumulating evidence that oxidative stress plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD).
Treasure, Tom, Hackett Tillie L, Warner Jane A, Wan Tan, Tan Wan, Lu Zheng, Tom Treasure, Hackett, Tillie-Louise, Scarci Marco, Treasure Tom, Zheng Lu, Marco Scarci, Jane A Warner, Warner, Jane A., Tillie L Hackett, Scarci, Marco, Zheng, Lu, Tan, Wan   +17 more
core   +1 more source

Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group

Respiratory Research, 2022
Introduction Despite improvements in medical science and public health, mortality of community-acquired pneumonia (CAP) has barely changed throughout the last 15 years.
Mathias W. Pletz, Andreas Vestergaard Jensen, Christina Bahrs, Claudia Davenport, Jan Rupp, Martin Witzenrath, Grit Barten-Neiner, Martin Kolditz, Sabine Dettmer, James D. Chalmers, Daiana Stolz, Norbert Suttorp, Stefano Aliberti, Wolfgang M. Kuebler, Gernot Rohde   +14 more
doaj   +1 more source

Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1

Frontiers in Medicine, 2020
Smokers with apparently “healthy” lungs suffer from more severe and frequent viral respiratory infections, but the mechanisms underlying this observation are still unclear.
Olga Danov, Martin Wolff, Sabine Bartel, Sabine Bartel, Sebastian Böhlen, Helena Obernolte, Sabine Wronski, Danny Jonigk, Barbara Hammer, Draginja Kovacevic, Sebastian Reuter, Sebastian Reuter, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann, Katherina Sewald   +14 more
doaj   +1 more source

Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies

Scientific Reports, 2022
Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer   +12 more
doaj   +1 more source

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +1 more source

Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study

Frontiers in Oncology, 2022
In the last decade, targeting the immune system became a promising therapy in advanced lung cancer stages. However, in a clinical follow-up, patient responses to immune checkpoint inhibitors widely differ.
Marc A. Schneider, Marc A. Schneider, Adriana Rozy, Sabine Wrenger, Sabine Wrenger, Petros Christopoulos, Petros Christopoulos, Thomas Muley, Thomas Muley, Michael Thomas, Michael Thomas, Michael Meister, Michael Meister, Tobias Welte, Tobias Welte, Joanna Chorostowska-Wynimko, Sabina Janciauskiene, Sabina Janciauskiene, Sabina Janciauskiene   +18 more
doaj   +1 more source

Lung function in the general population : the complex interplay of variants in "Serpina1" and other genes with the environment [PDF]

, 2013
Background. One of the globally most frequent health problems are obstructive lung diseases such as asthma and chronic obstructive pulmonary disease.
Thun, Gian Andri
core   +1 more source

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Frontiers in Pharmacology, 2018
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes.
Sabina Janciauskiene, Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte, Joanna Chorostowska-Wynimko   +7 more
doaj   +1 more source

Phenotypes of obstructive lung disease [PDF]

The Clinical Respiratory Journal, 2008
AbstractRecently, there has been much emphasis on the fact that there are many different phenotypes in asthma and chronic obstructive pulmonary disease (COPD). The aim of this review is to investigate some aspects of phenotyping in these two diseases.Epidemiological studies show a quite different risk factor pattern in allergic and non‐allergic asthma.
openaire   +2 more sources