Results 11 to 20 of about 3,148,779 (255)

Qualitative and quantitative evaluation of computed tomography changes in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor: a retrospective observational study

Frontiers in Pharmacology, 2023
Introduction: The availability of highly effective triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapy with elexacaftor–tezacaftor–ivacaftor (ETI) has improved pulmonary outcomes and quality of life of people ...
Sabine Dettmer, Sabine Dettmer, Oliver Weinheimer, Oliver Weinheimer, Annette Sauer-Heilborn, Oliver Lammers, Mark O. Wielpütz, Mark O. Wielpütz, Jan Fuge, Jan Fuge, Tobias Welte, Tobias Welte, Frank Wacker, Frank Wacker, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen   +16 more
doaj   +1 more source

Interleukin‐17A and interleukin‐22 production by conventional and non‐conventional lymphocytes in three different end‐stage lung diseases

Clinical & Translational Immunology, 2022
Objectives The contribution of adaptive vs. innate lymphocytes to IL‐17A and IL‐22 secretion at the end stage of chronic lung diseases remains largely unexplored. In order to uncover tissue‐ and disease‐specific secretion patterns, we compared production
Melanie Albrecht, Olga Halle, Svenja Gaedcke, Sophia T Pallenberg, Julia Camargo Neumann, Marius Witt, Johanna Roediger, Marina Schumacher, Adan Chari Jirmo, Gregor Warnecke, Danny Jonigk, Peter Braubach, David DeLuca, Gesine Hansen, Anna‐Maria Dittrich   +14 more
doaj   +1 more source

Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype

Cells, 2023
Whole-exome sequencing has expedited the diagnostic work-up of primary ciliary dyskinesia (PCD), when used in addition to clinical phenotype and nasal nitric oxide. However, it reveals variants of uncertain significance (VUS) in established PCD genes or (
Ben O. Staar, Jan Hegermann, Bernd Auber, Raphael Ewen, Sandra von Hardenberg, Ruth Olmer, Isabell Pink, Jessica Rademacher, Martin Wetzke, Felix C. Ringshausen   +9 more
doaj   +1 more source

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients

Biomolecules, 2022
Alpha-1-Antitrypsin (AAT) is a protein of the SERPINA1 gene. A single amino acid mutation (Lys342Glu) results in an expression of misfolded Z-AAT protein, which has a high propensity to intra- and extra-cellular polymerization.
Annelot D. Sark, Malin Fromme, Beata Olejnicka, Tobias Welte, Pavel Strnad, Sabina Janciauskiene, Jan Stolk   +6 more
doaj   +1 more source

Comparative Study on the Quality of Life of Chronic Obstructive Pulmonary Disease Patients [PDF]

Objective: The main goal of this study is to compare the Quality of Life (QoL) of Chronic Obstructive Pulmonary Disease (COPD) patients between three different regions: the United Arab Emirates (UAE), the United Kingdom (UK) and Morocco. Another aim of
Bihi, Imane Ben
core   +6 more sources

Spirometric and anthropometric improvements in response to elexacaftor/tezacaftor/ivacaftor depending on age and lung disease severity

Frontiers in Pharmacology, 2023
Introduction: Triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) was introduced in August 2020 in Germany for people with CF (pwCF) ≥12 years (yrs.) of age and in ...
Katharina Schütz, Katharina Schütz, Sophia Theres Pallenberg, Sophia Theres Pallenberg, Julia Kontsendorn, David DeLuca, David DeLuca, Cinja Sukdolak, Cinja Sukdolak, Rebecca Minso, Rebecca Minso, Tina Büttner, Tina Büttner, Tina Büttner, Martin Wetzke, Christian Dopfer, Annette Sauer-Heilborn, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Burkhard Tümmler, Gesine Hansen, Gesine Hansen, Anna-Maria Dittrich, Anna-Maria Dittrich   +26 more
doaj   +1 more source

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

eLife, 2021
Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions.
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy König, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene   +14 more
doaj   +1 more source

Chronic obstructive pulmonary disease: a complex comorbidity of lung cancer [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a major burden throughout the world. It is associated with a significantly increased incidence of lung cancer and may influence treatment options and outcome.
Derek Grose MRCP, FRCR, Robert Milroy, Grose, Derek, Milroy, Robert   +3 more
core   +1 more source

Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease [PDF]

, 2010
Background: there is accumulating evidence that oxidative stress plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD).
Treasure, Tom, Hackett Tillie L, Warner Jane A, Wan Tan, Tan Wan, Lu Zheng, Tom Treasure, Hackett, Tillie-Louise, Scarci Marco, Treasure Tom, Zheng Lu, Marco Scarci, Jane A Warner, Warner, Jane A., Tillie L Hackett, Scarci, Marco, Zheng, Lu, Tan, Wan   +17 more
core   +1 more source

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +1 more source