Results 41 to 50 of about 3,148,779 (255)

A data analytic model to determine regional variation of asthma incidence and other chronic obstructive lung diseases in Oman

Healthcare Analytics, 2022
This study examines how asthma and other chronic obstructive lung diseases vary in different regions. Information pertaining influence of region as a proxy for the environment on asthma is not well established, yet important for healthcare, travel, and ...
Khidir Abdelbasit, Ronald Wesonga
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

B cell activating factor (BAFF) levels are associated with failed remission after 12 months of treatment with benralizumab and mepolizumab in severe asthma

Respiratory Research
The introduction of biologicals interfering with the interleukin-5 (IL-5) pathway has revolutionized the treatment of severe eosinophilic asthma (SEA), rendering remission an achievable goal even in patients with previously uncontrolled disease.
Bettina Corinna Fischer, Nora Drick, Bin Liu, Lennart Riemann, Anika Habener, David DeLuca, Anna-Maria Dittrich, Marius M. Hoeper, Hendrik Suhling, Gesine Hansen, Ruth Grychtol   +10 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A novel agarose-free, standardized generation and versatile ECM characterization of decellularized scaffolds from normal and fibrotic human lung tissue

Frontiers in Bioengineering and Biotechnology
BackgroundThe extracellular matrix (ECM) is a key regulator of tissue homeostasis and remodeling in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP).
Eike B. Preuß, Eike B. Preuß, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Charlotte Hähner, Jérôme A. von Bandemer, Christopher Werlein, Edith K. J. Schwarz, Edith K. J. Schwarz, Stephanie Schubert, Holger Schlüter, Matthew J. Thomas, Danny D. Jonigk, Danny D. Jonigk, Jan C. Kamp, Jan C. Kamp, Mark P. Kühnel, Mark P. Kühnel   +17 more
doaj   +1 more source

Generation of two hiPSC lines (MHHi016-A, MHHi016-B) from a primary ciliary dyskinesia patient carrying a homozygous 5 bp duplication (c.248_252dup (p.Gly85Cysfs*11)) in exon 1 of the CCNO gene

Stem Cell Research, 2020
Cyclin O (CCNO) is involved in cell cycle regulation and mutations of CCNO are linked to the rare genetic disease primary ciliary dyskinesia (PCD).
Julia Dahlmann, Anais Sahabian, Nora Drick, Alexandra Haase, Gudrun Göhring, Nico Lachmann, Felix C. Ringshausen, Tobias Welte, Ulrich Martin, Ruth Olmer   +9 more
doaj   +1 more source

Automatic Screening of Lung Diseases by 3D Active Contour Method for Inhomogeneous Motion Estimation in CT Image Pairs

Walailak Journal of Science and Technology, 2021
Lung diseases are now the third leading cause of death worldwide because of the many risk factors we are exposed to daily, such as air pollution, tobacco use, viruses (such as COVID-19), and bacteria. This work introduces a new approach of the 3D Active
Pikul VEJJANUGRAHA, Kazunori KOTANI, Waree KONGPRAWECHNON, Toshiaki KONDO, Kanokvate TUNGPIMOLRUT   +4 more
doaj   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia

Journal of Translational Medicine
Background Distinguishing bacterial from viral community-acquired pneumonia (CAP) remains a major clinical challenge, often leading to inappropriate antimicrobial use. Alpha-1 antitrypsin (AAT) is an acute-phase protein that regulates neutrophil protease
Milad Pashai Fakhri, Friedemann R. Börner, Julia Held, Kokilavani Sivaraman, Jan Fuge, Jan Rupp, Grit Barten-Neiner, Mathias W. Pletz, Martin Witzenrath, Gernot Rohde, Jessica Rademacher, Christopher Alexander Hinze, Sabina Janciauskiene, CAPNETZ Study Group   +13 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source