Results 61 to 70 of about 184,952 (311)

Obstructive lung disease

, 2018
Abstract This chapter guides the reader on the diagnosis and management of obstructive lung disease in hospitalized patients.
Yuranga Weerakkody, Andrew Murphy, David Luong   +2 more
openaire   +2 more sources

Exploring the effects of tinzaparin and cisplatin on lung cancer cells in vitro

Cancer Cell International
Background Low molecular weight heparins (LMWH) are widely used to prevent or treat cancer- and thrombosis-related conditions. However, their direct effects on cancer cells remain unclear. Methods Nine non-small cell lung cancer (NSCLC) cell lines (H1437,
Julia Held, Marc A. Schneider, Beatriz Martinez-Delgado, Bin Liu, David S. DeLuca, Elena Korenbaum, Sabina Janciauskiene, Thomas Muley   +7 more
doaj   +1 more source

Spirometry and Obstructive Lung Disease in Manitoba

Canadian Respiratory Journal, 2001
BACKGROUND: Spirometry, the measurement of forced expiratory volume in 1 s and forced vital capacity, is recommended in the diagnosis and management of the obstructive lung diseases asthma and chronic obstructive pulmonary disease (COPD).
NR Anthonisen, N Dik, J Manfreda, LL Roos   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The healthcare needs of chronic obstructive pulmonary disease patients in the last year of life

, 2005
Chronic obstructive pulmonary disease (COPD) causes almost as many deaths as lung cancer, yet evidence about the impact of COPD in the latter stages of illness is limited. We assessed the healthcare needs of COPD patients in the last year of life through
White, P; id_orcid, Edmonds, P, Elkington, H., Addington-Hall, J., Higgs, R., Higgs, R, White, P., Edmonds, P., Elkington, H, ddington-Hall, J   +9 more
core   +1 more source

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Groneberg, David A., David A Groneberg, Fischer, Axel, Frank R Scholz, Springer, Jochen, Jochen Springer, Groneberg, Jan David Alexander, Christian Peiser, Scholz, Frank R., Axel Fischer, Peiser, Christian, Q Dinh, Quarcoo, David, David Quarcoo, Dinh, Q. Thai   +14 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Models of chronic obstructive pulmonary disease

, 2004
Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments ...
David A Groneberg, Chung K Fan, Chung, K. Fan, Groneberg, Jan David Alexander, Groneberg David A, K Fan Chung   +5 more
core   +1 more source