Results 51 to 60 of about 934,333 (350)

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

B cell activating factor (BAFF) levels are associated with failed remission after 12 months of treatment with benralizumab and mepolizumab in severe asthma

Respiratory Research
The introduction of biologicals interfering with the interleukin-5 (IL-5) pathway has revolutionized the treatment of severe eosinophilic asthma (SEA), rendering remission an achievable goal even in patients with previously uncontrolled disease.
Bettina Corinna Fischer, Nora Drick, Bin Liu, Lennart Riemann, Anika Habener, David DeLuca, Anna-Maria Dittrich, Marius M. Hoeper, Hendrik Suhling, Gesine Hansen, Ruth Grychtol   +10 more
doaj   +1 more source

A novel agarose-free, standardized generation and versatile ECM characterization of decellularized scaffolds from normal and fibrotic human lung tissue

Frontiers in Bioengineering and Biotechnology
BackgroundThe extracellular matrix (ECM) is a key regulator of tissue homeostasis and remodeling in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP).
Eike B. Preuß, Eike B. Preuß, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Charlotte Hähner, Jérôme A. von Bandemer, Christopher Werlein, Edith K. J. Schwarz, Edith K. J. Schwarz, Stephanie Schubert, Holger Schlüter, Matthew J. Thomas, Danny D. Jonigk, Danny D. Jonigk, Jan C. Kamp, Jan C. Kamp, Mark P. Kühnel, Mark P. Kühnel   +17 more
doaj   +1 more source

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. [PDF]

, 2014
BackgroundPreserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality.
Beaty, Terri H, Castaldi, Peter J, Cho, Michael H, COPDGene Investigators, Crapo, James D, Curran-Everett, Douglas, Curtis, Jeffrey L, DeMeo, Dawn L, Han, MeiLan K, Hokanson, John E, Lynch, David A, Make, Barry J, Regan, Elizabeth A, Silverman, Edwin K, Wan, Emily S   +14 more
core   +2 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Type 2 responses determine skin rash during recombinant interleukin-2 therapy

Journal of Immunotoxicology
The skin is the organ most often affected by adverse drug reactions. Although these cutaneous adverse drug reactions (CADRs) often are mild, they represent a major burden for patients.
Charline Sommer, Vanessa Neuhaus, Patricia Gogesch, Thierry Flandre, Susann Dehmel, Katherina Sewald   +5 more
doaj   +1 more source

Nanoparticles in the treatment of chronic lung diseases [PDF]

, 2019
Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G, Cosnarovici, Maria, Negrean, Vasile, Orasan, Olga H, Para, Ioana, Perne, Mirela G, Popovici, Ionela, Ruta, Victoria M, Tarmure, Simina, Todea, Doina A   +9 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection

Respiratory Research
Human parainfluenza virus 3 is a highly abundant RNA virus that primarily affects young children, the elderly, and immunocompromised individuals, leading to severe lower respiratory infections and pneumonia.
Olga Danov, Philippe Vollmer Barbosa, Helena Obernolte, Maximilian Fuchs, Patrice Guillon, Larissa Dirr, Ibrahim El-Deeb, Meik Kunz, Leonie Hose, Gaël Martin, Fabian Röpken, Anna Zimmer, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Sabine Wronski, Mark von Itzstein, Thomas Tschernig, Armin Braun, Katherina Sewald   +20 more
doaj   +1 more source