Results 31 to 40 of about 184,952 (311)

Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation

Stem Cell Research, 2020
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia.
Sylvia Merkert, Madline Schubert, Alexandra Haase, Hettie M. Janssens, Bob Scholte, Nico Lachmann, Gudrun Göhring, Ulrich Martin   +7 more
doaj   +1 more source

Processed meat consumption and lung function: modification by antioxidants and smoking [PDF]

, 2014
Unhealthy dietary patterns are associated with poorer lung function. It is not known whether this is due to low consumption of antioxidant-rich fruit and vegetables, or is a consequence of higher intakes of harmful dietary constituents such as processed ...
Okubo, H., Syddall, H.E., Aihie Sayer, A., Sayer, AA, Shaheen, S.O., Grp, HCS, Cooper, C., Ntani, G, Jameson, KA, Robinson, SM, Dennison, E.M., Dennison, EM, Cooper, Cyrus, Cooper, C, Shaheen, SO, Syddall, HE, Okubo, H, Robinson, S.M., Ntani, G.   +18 more
core   +1 more source

When clearance fails: the role of efferocytosis in COPD

European Respiratory Review
Despite the enormous global burden associated with chronic obstructive pulmonary disease (COPD), its precise underlying mechanisms remain incompletely understood. A key feature of COPD is persistent, nonresolving inflammation, traditionally attributed to
Iris S. Tournoy, Silke Geirnaert, Dmitry V. Krysko, Ken R. Bracke   +3 more
doaj   +1 more source

Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial [PDF]

, 2010
Background Acute exacerbations contribute to the morbidity and mortality associated with chronic obstructive pulmonary disease (COPD). This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of ...
Jones, PW, Badenhorst J., Sethi S., Cukier A., Miravitlles, M, Sethi, S, Clancy L., Marlize Schmitt Theron, Bitter-Suermann S., Miravitlles Marc, Bettendorf A., Nadar R., Sanjay Sethi, Queguiner A., Rubinstein, E, Potena A., Naude G., PULSE Study group, Abenhaim N., Schroder-Babo W., Di Bartolo C., null null, Theron, MS, Kroemer B., Ferreyra R., del Campo F., de Oliveira J. A., Wedzicha J. A., Jones P. W., Killian J., Watz H., Millar A., Toubis M., Jadwiga A Wedzicha, Molitor S., Anzueto A., Gebhardt R., Groth G., Sanchez R. P., Peraza R. B., Sharafkhaneh A., Bassaris H., Smith C., Wilson Robert, Merida F. C., Fritscher C., Joubert J., Sethi Sanjay, Llamas F. S., Parada M., Alvarez-Sala L., Rubinstein Ethan, Raz P., Cote C., Vlastos F., Legnani D., Richter K., Menendez R., Barnes N. C., Viljoen J., Hasan S., Lalanne G., Wilson, R, Rubinstein E., Rastogi P., Elliott M., Bolio F. T., Fernandez P., Gaines S., Colberg K., Schaberg T., Harari S., Triot P., Monso E., Nieuwoudt G., Westerhausen U., Paul W Jones, Mans W., O'Connell F., Prins M., Dichmann R., Miravitlles M., Taminau D., Raz M., Ignacio J. M., Plautz M., Jones Paul W, Theron M. S., Zeltser D., Habib M., Kawley F., Jardim J. B., Linnhoff A., Weiler Z., Cutillas J. R., Wedzicha Jadwiga A, Robert Wilson, Barros M., Stockley R., Ethan Rubinstein, Wedzicha, JA, Wilson R., Mahutte C. K., Bugnas B., Littner M., Marc Miravitlles, Luna C., Theron Marlize, Hosp H. A., Pozzi E., Groth J.   +110 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

B cell activating factor (BAFF) levels are associated with failed remission after 12 months of treatment with benralizumab and mepolizumab in severe asthma

Respiratory Research
The introduction of biologicals interfering with the interleukin-5 (IL-5) pathway has revolutionized the treatment of severe eosinophilic asthma (SEA), rendering remission an achievable goal even in patients with previously uncontrolled disease.
Bettina Corinna Fischer, Nora Drick, Bin Liu, Lennart Riemann, Anika Habener, David DeLuca, Anna-Maria Dittrich, Marius M. Hoeper, Hendrik Suhling, Gesine Hansen, Ruth Grychtol   +10 more
doaj   +1 more source

A novel agarose-free, standardized generation and versatile ECM characterization of decellularized scaffolds from normal and fibrotic human lung tissue

Frontiers in Bioengineering and Biotechnology
BackgroundThe extracellular matrix (ECM) is a key regulator of tissue homeostasis and remodeling in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP).
Eike B. Preuß, Eike B. Preuß, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Charlotte Hähner, Jérôme A. von Bandemer, Christopher Werlein, Edith K. J. Schwarz, Edith K. J. Schwarz, Stephanie Schubert, Holger Schlüter, Matthew J. Thomas, Danny D. Jonigk, Danny D. Jonigk, Jan C. Kamp, Jan C. Kamp, Mark P. Kühnel, Mark P. Kühnel   +17 more
doaj   +1 more source

Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review [PDF]

, 2009
Exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the natural history of this prevalent and devastating condition. This review provides a concise, state of the art summary on prevention and management of exacerbations.
Hurst, JR, Hurst John R, Wedzicha Jadwiga A, Wedzicha, JA, John R Hurst, Jadwiga A Wedzicha   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Type 2 responses determine skin rash during recombinant interleukin-2 therapy

Journal of Immunotoxicology
The skin is the organ most often affected by adverse drug reactions. Although these cutaneous adverse drug reactions (CADRs) often are mild, they represent a major burden for patients.
Charline Sommer, Vanessa Neuhaus, Patricia Gogesch, Thierry Flandre, Susann Dehmel, Katherina Sewald   +5 more
doaj   +1 more source