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The role of goblet cells in Crohn’ s disease [PDF]
Cell & BioscienceThe prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, and bacterial factors.
Zichen Wang, Jun Shen
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Goblet cells need some stress [PDF]
The Journal of Clinical Investigation, 2022 The intestinal tract is protected by epithelium-covering mucus, which is constantly renewed by goblet cells, a specialized type of epithelial cell. Mucus is largely composed of MUC2 mucin, an enormous molecule that poses a high demand on the endoplasmic ...
Malin E.V. Johansson, Gunnar C. Hansson
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Inhibition of microRNA-328 Increases Ocular Mucin Expression and Conjunctival Goblet Cells [PDF]
Biomedicines, 2023 We previously reported anti-miR-328 therapy for dry eye disease (DED). Since decreased mucin secretion is a risk factor for DED, we aimed to explore whether anti-miR-328 affects mucin expression and goblet cells.
Jackson Choo +6 more
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DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation [PDF]
Advanced ScienceThe colonic mucus barrier, dependent on goblet cell‐secreted mucin2 (Muc2), prevents microbial invasion. Compound exocytosis enables the rapid, high‐volume release of mucus from goblet cells; its underlying mechanisms, however, remain unclear.
Ying Wang +9 more
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Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Journal of Inflammation Research, 2021 Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery ...
Yang S, Yu M
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Detecting Intestinal Goblet Cells of the Broadgilled Hagfish Eptatretus cirrhatus (Forster, 1801): A Confocal Microscopy Evaluation [PDF]
Biology, 2022 The fish intestine operates as a complicated interface between the organism and the environment, providing biological and mechanical protections as a result of a viscous layer of mucus released by goblet cells, which serves as a barrier against bacteria,
Alessio Alesci +10 more
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ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions [PDF]
Experimental and Molecular Medicine, 2023 Inflammatory bowel disease: A protective enzyme in intestinal goblet cells Studies of inflammatory bowel disease (IBD) in mice reveal the role of an enzyme that assists the degradation of mis-folded proteins in the ‘goblet’ cells involved in producing ...
Hyunjin Jeong +13 more
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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
Life Science Alliance, 2022 The histone methyltransferase Mll1 controls intestinal secretory cell fate by promoting Wnt-driven Paneth and restricting Mapk-dependent goblet cell differentiation through regulation of Gata4/6 transcription factors Differentiation and lineage ...
Johanna Grinat +8 more
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Mucus and the Goblet Cell [PDF]
Digestive Diseases, 2013 The discovery of an inner mucus layer normally impervious to bacteria has changed our way of understanding the interaction between commensal bacteria and the host epithelial cells. This inner colon mucus layer is rapidly renewed and converted into the outer mucus layer by host controlled endogenous proteolytic processing.
Malin E V, Johansson, Gunnar C, Hansson
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Goblet Cell Carcinoids of the Appendix [PDF]
The Scientific World Journal, 2013 Goblet cell carcinoid (GCC) tumors are a rare subgroup of neuroendocrine tumors almost exclusively originating in the appendix. The tumor most often presents in the fifth or sixth decade with a clinical picture of appendicitis or in advanced cases an abdominal mass associated with abdominal pain.
Holt, Nanna; id_orcid 0000-0002-2032-1691 +1 more
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