The role of goblet cells in Crohn’ s disease [PDF]
Cell & BioscienceThe prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, and bacterial factors.
Zichen Wang, Jun Shen
doaj +2 more sources
Goblet cells need some stress [PDF]
The Journal of Clinical Investigation, 2022 The intestinal tract is protected by epithelium-covering mucus, which is constantly renewed by goblet cells, a specialized type of epithelial cell. Mucus is largely composed of MUC2 mucin, an enormous molecule that poses a high demand on the endoplasmic ...
Malin E.V. Johansson, Gunnar C. Hansson
doaj +2 more sources
Inhibition of microRNA-328 Increases Ocular Mucin Expression and Conjunctival Goblet Cells [PDF]
Biomedicines, 2023 We previously reported anti-miR-328 therapy for dry eye disease (DED). Since decreased mucin secretion is a risk factor for DED, we aimed to explore whether anti-miR-328 affects mucin expression and goblet cells.
Jackson Choo +6 more
doaj +2 more sources
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. [PDF]
PLoS ONE, 2013 The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can ...
Victoria E McGilligan +7 more
doaj +8 more sources
DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation [PDF]
Advanced ScienceThe colonic mucus barrier, dependent on goblet cell‐secreted mucin2 (Muc2), prevents microbial invasion. Compound exocytosis enables the rapid, high‐volume release of mucus from goblet cells; its underlying mechanisms, however, remain unclear.
Ying Wang +9 more
doaj +2 more sources
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Journal of Inflammation Research, 2021 Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery ...
Yang S, Yu M
doaj +2 more sources
Detecting Intestinal Goblet Cells of the Broadgilled Hagfish Eptatretus cirrhatus (Forster, 1801): A Confocal Microscopy Evaluation [PDF]
Biology, 2022 The fish intestine operates as a complicated interface between the organism and the environment, providing biological and mechanical protections as a result of a viscous layer of mucus released by goblet cells, which serves as a barrier against bacteria,
Alessio Alesci +10 more
doaj +2 more sources
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions [PDF]
Experimental and Molecular Medicine, 2023 Inflammatory bowel disease: A protective enzyme in intestinal goblet cells Studies of inflammatory bowel disease (IBD) in mice reveal the role of an enzyme that assists the degradation of mis-folded proteins in the ‘goblet’ cells involved in producing ...
Hyunjin Jeong +13 more
doaj +2 more sources
Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
Life Science Alliance, 2022 The histone methyltransferase Mll1 controls intestinal secretory cell fate by promoting Wnt-driven Paneth and restricting Mapk-dependent goblet cell differentiation through regulation of Gata4/6 transcription factors Differentiation and lineage ...
Johanna Grinat +8 more
doaj +1 more source
Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture
BMJ Open Ophthalmology, 2020 Objective To determine the effect of povidone iodine (PI), an antiseptic commonly used prior to ocular surgery, on viability of mixed populations of conjunctival stratified squamous and goblet cells, purified conjunctival goblet cells and purified ...
Miriam Kolko +12 more
doaj +1 more source