Increased levels of α2-3- and α2-6-linked sialic acids during airway inflammation govern influenza A binding to peripheral airway mucins in a subtype-dependent manner [PDF]
Frontiers in ImmunologyBackgroundInfluenza infection increases the risk of pneumonia and respiratory failure in chronic obstructive pulmonary disease (COPD) and mucins play an important role in pulmonary host defense.MethodsLower airway mucins were obtained from long-term ...
John Benktander +9 more
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Airway Mucosal Defense: Mucins, Innate Immunity, and Contemporary Mucoactive Strategies [PDF]
BiomedicinesMucins are highly glycosylated proteins that form the structural basis of mucus and represent a key component of innate immunity at mucosal surfaces, particularly in the respiratory tract.
Almira Akparova +9 more
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Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections
Pathogens, 2013 Goblet cells reside throughout the gastrointestinal (GI) tract and are responsible for the production and preservation of a protective mucus blanket by synthesizing and secreting high molecular weight glycoproteins known as mucins.
Waliul I Khan, Janice J Kim
exaly +3 more sources
Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells. [PDF]
PLoS ONE, 2012 Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere.
Emma C Skoog +5 more
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Assay for Assessing Mucin Binding to Bacteria and Bacterial Proteins
Bio-Protocol, 2021 Legionella pneumophila, a Gram-negative bacterium and the causative agent of Legionnaires’ disease, exports over 300 effector proteins/virulence factors, through its type II (T2SS) and type IV secretion systems (T4SS).
Lubov Grigoryeva +4 more
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Comparison of the transmembrane mucins MUC1 and MUC16 in epithelial barrier function. [PDF]
PLoS ONE, 2014 Membrane-anchored mucins are present in the apical surface glycocalyx of mucosal epithelial cells, each mucosal epithelium having at least two of the mucins.
Ilene K Gipson +3 more
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Role of Anthocyanins in the Interaction between Salivary Mucins and Wine Astringent Compounds
Foods, 2023 Wine astringency is a very complex sensation whose complete mechanism has not been entirely described. Not only salivary proline-rich proteins (PRPs) are involved in its development; salivary mucins can also play an important role.
Bárbara Torres-Rochera +3 more
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PLoS Neglected Tropical Diseases, 2022 Host cell invasion is a critical step for infection by Trypanosoma cruzi, the agent of Chagas disease. In natural infection, T. cruzi metacyclic trypomastigote (MT) forms establish the first interaction with host cells.
Thiago Souza Onofre +4 more
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Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE:To evaluate the effects of sucralfate on tissue content of neutral and acids mucins in rats with diversion colitis.METHODS: Thirty-six rats were submitted to a proximal right colostomy and a distal mucous fistula.
Felipe Mendonça Chaim +6 more
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Stem Cell Research, 2015 The intestinal epithelium is a particularly attractive biological adult model to study epigenetic mechanisms driving adult stem cell renewal and cell differentiation.
Audrey Vincent +5 more
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