Results 1 to 10 of about 255,241 (301)

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Nature Communications, 2016
Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination ...
Chia‐Wei Li, Seung-Oe Lim, W. Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, K. Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, J. Hsu, Yun Wu, Jung-Mao Hsu, H. Yamaguchi, Q. Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, A. Sahin, J. Allison, Dihua Yu, G. Hortobagyi, M. Hung   +23 more
semanticscholar   +1 more source

Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

Nature Medicine, 2020
The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood.
Hiroko Nagao-Kitamoto, Jhansi L. Leslie, Sho Kitamoto, C. Jin, K. Thomsson, Merritt G. Gillilland, Peter Kuffa, Y. Goto, R. Jenq, Chiharu Ishii, A. Hirayama, Anna M. Seekatz, E. Martens, K. Eaton, J. Kao, S. Fukuda, P. Higgins, N. Karlsson, V. Young, N. Kamada   +19 more
semanticscholar   +1 more source

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The novel SARS-CoV-2 coronavirus that is responsible for the global pandemic contains a unique insertion of four amino acids within the spike protein (S).
Liping Zhang, Matthew Mann, Zulfeqhar A. Syed, H. Reynolds, E. Tian, N. Samara, D. Zeldin, L. Tabak, K. T. Ten Hagen   +8 more
semanticscholar   +1 more source

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen

mBio, 2019
In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid, Simon J. North, Paul Hitchen, Prerna Vohra, Cosmin Chintoan-Uta, Mark Stevens, Anne Dell, Jon Cuccui, Brendan W. Wren   +8 more
doaj   +1 more source

New insight into protein glycosylation in the development of Alzheimer’s disease

Cell Death Discovery, 2023
Alzheimer’s disease (AD) is a chronic neurodegenerative disease that seriously endangers the physical and mental health of patients, however, there are still no effective drugs or methods to cure this disease up to now.
Jingwei Zhao, Minglin Lang
doaj   +1 more source

PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy

Journal for ImmunoTherapy of Cancer, 2021
Background Combination therapy has been explored for advanced head and neck squamous cell carcinoma (HNSCC) owing to the limited efficacy of anti-epidermal growth factor receptor (EGFR) therapy. Increased expression and glycosylation of immune checkpoint
Yiqi Xu, Zhenyue Gao, Ruxin Hu, Yuqing Wang, Yuhong Wang, Zheng Su, Xiaoyue Zhang, Jingxuan Yang, M. Mei, Yu Ren, Min Li, Xuan Zhou   +11 more
semanticscholar   +1 more source

Altered glycosylation in cancer: molecular functions and therapeutic potential

Cancer Communications
Glycosylation, a key mode of protein modification in living organisms, is critical in regulating various biological functions by influencing protein folding, transportation, and localization. Changes in glycosylation patterns are a significant feature of
Xuemeng Xu, Qiu Peng, Xianjie Jiang, Shiming Tan, Wenjuan Yang, Yaqian Han, L. Oyang, Jinguan Lin, Mengzhou Shen, Jiewen Wang, Haofan Li, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hui Wang, Q. Liao, Yujuan Zhou   +17 more
semanticscholar   +1 more source

Antibody Glycosylation in Autoimmune Diseases

Autoimmunity Reviews, 2021
The glycosylation of the fragment crystallizable (Fc) region of immunoglobulins (Ig) is critical for the modulation of antibody effects on inflammation. Moreover, antibody glycosylation may induce pathologic modifications and ultimately contribute to the
Xing Zhou, F. Motta, C. Selmi, W. Ridgway, M. Gershwin, Weici Zhang   +5 more
semanticscholar   +1 more source

DC-SIGN Binding Contributed by an Extra N-Linked Glycosylation on Japanese Encephalitis Virus Envelope Protein Reduces the Ability of Viral Brain Invasion

Frontiers in Cellular and Infection Microbiology, 2018
The major structural envelope (E) protein of Japanese encephalitis virus (JEV) facilitates cellular binding/entry and is the primary target of neutralizing antibodies.
Jian-Jong Liang, Min-Wei Chou, Yi-Ling Lin, Yi-Ling Lin   +3 more
doaj   +1 more source

Glycosylation site alteration in the evolution of influenza A (H1N1) viruses. [PDF]

PLoS ONE, 2011
Influenza virus typically alters protein glycosylation in order to escape immune pressure from hosts and hence to facilitate survival in different host environments.
Shisheng Sun, Qinzhe Wang, Fei Zhao, Wentian Chen, Zheng Li   +4 more
doaj   +1 more source