Results 41 to 50 of about 255,241 (301)
Orphanet Journal of Rare Diseases, 2018 Background Health-related Quality of Life (HrQoL) is a multidimensional measure, which has gained clinical and social relevance. Implementation of a patient-centred approach to both clinical research and care settings, has increased the recognition of ...
Carlota Pascoal +8 more
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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Nature Communications, 2020 Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential.
Yasunori Watanabe +10 more
semanticscholar +1 more source
Frontiers in Cardiovascular Medicine, 2022 High-density lipoprotein (HDL) particles, long known for their critical role in the prevention of cardiovascular disease (CVD), were recently identified to carry a wide array of glycosylated proteins, and the importance of this glycosylation in the ...
Eduardo Z. Romo, Angela M. Zivkovic
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Altered glycosylation in cancer: A promising target for biomarkers and therapeutics
Biochimica et biophysica acta. Reviews on cancer, 2020 Glycosylation is a well-regulated cell and microenvironment specific post-translational modification. Several glycosyltransferases and glycosidases orchestrate the addition of defined glycan structures on the proteins and lipids.
D. Thomas +2 more
semanticscholar +1 more source
Cells, 2021 Glycans are major constituents of extracellular vesicles (EVs). Alterations in the glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or increased synthesis of particular glycans.
Álvaro M Martins +3 more
semanticscholar +1 more source
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
Nature reviews: Gastroenterology & hepatology, 2020 Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors have been implicated in IBD pathogenesis, including host genetics, immune dysregulation and gut microbiota alterations.
M. Kudelka +3 more
semanticscholar +1 more source
Current Research in Pharmacology and Drug Discovery, 2022 Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development.
Ziyuan Gao +6 more
doaj +1 more source
IgA subclasses have different effector functions associated with distinct glycosylation profiles
Nature Communications, 2020 Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but the regulation of serum IgA effector functions is not well defined.
U. Steffen +21 more
semanticscholar +1 more source
Glycosylation in cellular mechanisms of health and disease.
Cell, 2006 Glycosylation produces an abundant, diverse, and highly regulated repertoire of cellular glycans that are frequently attached to proteins and lipids.
K. Ohtsubo, J. Marth
semanticscholar +1 more source
Exploitation of glycosylation in enveloped virus pathobiology
Biochimica et Biophysica Acta - General Subjects, 2019 Glycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication.
Yasunori Watanabe +3 more
semanticscholar +1 more source