Results 31 to 40 of about 255,241 (301)
Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy.
Biotechnology Advances, 2023 Glycosylation-mediated post-translational modification is critical for regulating many fundamental processes like cell division, differentiation, immune response, and cell-to-cell interaction. Alterations in the N-linked or O-linked glycosylation pattern
Rashmi Bangarh +10 more
semanticscholar +1 more source
Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics
Molecules, 2023 Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety.
Renato Mastrangeli +2 more
doaj +1 more source
Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation
FEBS Open Bio, 2020 Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé +5 more
doaj +1 more source
Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2
bioRxiv, 2020 The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities.
A. Shajahan +3 more
semanticscholar +1 more source
N-Glycosylation and Inflammation; the Not-So-Sweet Relation
Frontiers in Immunology, 2022 Chronic inflammation is the main feature of many long-term inflammatory diseases such as autoimmune diseases, metabolic disorders, and cancer. There is a growing number of studies in which alterations of N-glycosylation have been observed in many ...
Barbara Radovani, I. Gudelj
semanticscholar +1 more source
Medical Mycology, 2001 O-Glycosylation in many fungal species is initiated in the endoplasmic reticulum by protein mannosyltransferases (Pmt-proteins), which transfer mannose to serine or threonine residues, and it is completed by mannosyltransferases (Mnt-proteins) in the Golgi.
J F, Ernst, S K, Prill
openaire +2 more sources
Nature Communications, 2021 Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein.
Yun Huang +17 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Glycosylation alterations, a key driver throughout tumorigenesis and tumor progression, could regulate the microenvironment and immune response as well as lead to harmful metabolism and cell signaling.
Guihua Tang +3 more
doaj +1 more source
eLife, 2021 Osteocalcin is a bone matrix protein that acts like a hormone when it reaches the blood, and has different effects in mice and humans.
Harry C Blair, Paul H Schlesinger
openaire +3 more sources
Frontiers in Microbiology, 2021 Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions.
Liubov Yakovlieva +2 more
doaj +1 more source