Increased levels of α2-3- and α2-6-linked sialic acids during airway inflammation govern influenza A binding to peripheral airway mucins in a subtype-dependent manner. [PDF]
Front ImmunolBackgroundInfluenza infection increases the risk of pneumonia and respiratory failure in chronic obstructive pulmonary disease (COPD) and mucins play an important role in pulmonary host defense.MethodsLower airway mucins were obtained from long-term ...
Benktander J +6 more
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Comparison of the transmembrane mucins MUC1 and MUC16 in epithelial barrier function. [PDF]
PLoS ONE, 2014 Membrane-anchored mucins are present in the apical surface glycocalyx of mucosal epithelial cells, each mucosal epithelium having at least two of the mucins.
Ilene K Gipson +3 more
doaj +6 more sources
Frontiers in Immunology, 2020 Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly glycosylated proteins called mucins plays an essential role in providing lubrication for the passage of food, participating in cell signaling pathways and protecting ...
Yun Han Kwon, Sabah Haq, Waliul I Khan
exaly +3 more sources
Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines [PDF]
Frontiers in Chemistry, 2019 Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in many biological processes ...
Sandra Pinzón Martín +5 more
doaj +3 more sources
Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins. [PDF]
Nat CommunThe mucus lining wet body surfaces forms the interphase and barrier for the microbiota and resident microbiomes. Large mucin proteins densely decorated with O-glycans make up the mucus lining to entrap, feed and shape the microbiota, and repress biofilm ...
Jaroentomeechai T +22 more
europepmc +2 more sources
Annals of Dermatology, 2018 Mucinous nevus is an uncommon entity classified as either a cutaneous mucinosis or a connective tissue nevus. The condition presents as grouped papules and coalescent plaques growing in a unilateral or zosteriform manner. The key histopathological feature is a band-like deposition of mucin in the superficial dermis.
Min Young Lee +3 more
openaire +2 more sources
Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells. [PDF]
PLoS ONE, 2012 Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere.
Emma C Skoog +5 more
doaj +1 more source
Assay for Assessing Mucin Binding to Bacteria and Bacterial Proteins
Bio-Protocol, 2021 Legionella pneumophila, a Gram-negative bacterium and the causative agent of Legionnaires’ disease, exports over 300 effector proteins/virulence factors, through its type II (T2SS) and type IV secretion systems (T4SS).
Lubov Grigoryeva +4 more
doaj +1 more source
Role of Anthocyanins in the Interaction between Salivary Mucins and Wine Astringent Compounds
Foods, 2023 Wine astringency is a very complex sensation whose complete mechanism has not been entirely described. Not only salivary proline-rich proteins (PRPs) are involved in its development; salivary mucins can also play an important role.
Bárbara Torres-Rochera +3 more
doaj +1 more source
Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE:To evaluate the effects of sucralfate on tissue content of neutral and acids mucins in rats with diversion colitis.METHODS: Thirty-six rats were submitted to a proximal right colostomy and a distal mucous fistula.
Felipe Mendonça Chaim +6 more
doaj +2 more sources