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Mucins and the Microbiome [PDF]
Annual Review of Biochemistry, 2020 Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two types, gel-forming and transmembrane, all characterized by large, highly O -glycosylated mucin domains that are diversely decorated by Golgi
Hansson, Gunnar C.,
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Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins [PDF]
Nature CommunicationsThe mucus lining wet body surfaces forms the interphase and barrier for the microbiota and resident microbiomes. Large mucin proteins densely decorated with O-glycans make up the mucus lining to entrap, feed and shape the microbiota, and repress biofilm ...
Thapakorn Jaroentomeechai +22 more
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Salivary mucins in host defense and disease prevention
Journal of Oral Microbiology, 2015 Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical ...
Erica Shapiro Frenkel, Katharina Ribbeck
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, 2015 Mucosal surfaces are exposed to the external environment and pathogens and are therefore protected by a secreted layer of mucus rich in mucin glycoproteins, which are the main components of mucus. Mucus provides physical protection and hydration, excludes pathogens, and is a reservoir for antimicrobial molecules.
McGuckin, Michael A. +2 more
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Identification and characterisation of mucin abnormalities in the ganglionic bowel in Hirschsprung's disease [PDF]
, 2010 MDHirschsprung’s disease (HD) is a congenital abnormality of unknown origin, characterised by a lack of ganglion cells in the distal colon which results in functional colonic obstruction.
Speare, Ruth Marian
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Annals of Dermatology, 2018 Mucinous nevus is an uncommon entity classified as either a cutaneous mucinosis or a connective tissue nevus. The condition presents as grouped papules and coalescent plaques growing in a unilateral or zosteriform manner. The key histopathological feature is a band-like deposition of mucin in the superficial dermis.
Min Young Lee +3 more
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Histochemical Assessment of Mucin-Secreting Cells from the Gastric Mucosa of Guinea Pigs
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2020 Stomach fragments from 3 guinea pigs were collected from the three regions: cardiac, fundic and pyloric, for histochemical investigations. The anatomical segments were processed by the classical method of inclusion in paraffin and the histological ...
Adriana CHENDE +6 more
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Journal of Translational Medicine, 2018 Background MUC4 is a membrane-bound mucin that promotes carcinogenetic progression and is often proposed as a promising biomarker for various carcinomas.
Nicolas Jonckheere +1 more
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Heterogeneity and persistence length in human ocular mucins [PDF]
, 2002 Atomic force microscopy (AFM) has been used to investigate the heterogeneity and flexibility of human ocular mucins and their subunits. We have paid particular attention, in terms of theory and experiment, to the problem of inducing the polymers to ...
Stoll, S. +23 more
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A potential role for Drosophila mucins in development and physiology. [PDF]
PLoS ONE, 2008 Vital vertebrate organs are protected from the external environment by a barrier that to a large extent consists of mucins. These proteins are characterized by poorly conserved repeated sequences that are rich in prolines and potentially glycosylated ...
Zulfeqhar A Syed +3 more
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