Results 21 to 30 of about 29,585 (261)

Is the colon mucosa affected by ten days of gastric restriction in an animal model? [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats.
Flávia Emi Akamatsu, Luiz Gustavo Fontes, Ana Maria Itezerote, Samir Saleh, Walcy Paganelli Rosolia Teodoro, Everson Artifon, Flávio Hojaij, Mauro Andrade, José Aires Pereira, Carlos Augusto Real Martinez, Alfredo Luiz Jacomo   +10 more
doaj   +1 more source

Mucins as diagnostic and prognostic biomarkers in a fish-parasite model: transcriptional and functional analysis. [PDF]

PLoS ONE, 2013
Mucins are O-glycosylated glycoproteins present on the apex of all wet-surfaced epithelia with a well-defined expression pattern, which is disrupted in response to a wide range of injuries or challenges.
Jaume Pérez-Sánchez, Itziar Estensoro, María José Redondo, Josep Alvar Calduch-Giner, Sadasivam Kaushik, Ariadna Sitjà-Bobadilla   +5 more
doaj   +1 more source

Fish pathogen binding to mucins from Atlantic salmon and Arctic char differs in avidity and specificity and is modulated by fluid velocity.

PLoS ONE, 2019
Disease outbreaks are limiting factors for an ethical and economically sustainable aquaculture industry. The first point of contact between a pathogen and a host occurs in the mucus, which covers the epithelial surfaces of the skin, gills and ...
János Tamás Padra, Abarna V M Murugan, Kristina Sundell, Henrik Sundh, John Benktander, Sara K Lindén, Sara K Lindén   +6 more
doaj   +1 more source

Salivary mucins in host defense and disease prevention

Journal of Oral Microbiology, 2015
Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical ...
Erica Shapiro Frenkel, Katharina Ribbeck
doaj   +1 more source

Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile

BMC Genomics, 2011
Background Mucins are large glycoproteins implicated in protection of all mucosal surfaces. In humans and rodents, the mucin gene family has been well described and previous studies have investigated the distribution and function of mucins in the ...
Vercruysse Jozef, Claerebout Edwin, Goddeeris Bruno, Li Robert W, Rinaldi Manuela, Hoorens Prisca R, Geldhof Peter   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Airway Mucins Inhibit Oxidative and Non-Oxidative Bacterial Killing by Human Neutrophils

Frontiers in Pharmacology, 2020
Neutrophil killing of bacteria is mediated by oxidative and non-oxidative mechanisms. Oxidants are generated through the NADPH oxidase complex, whereas antimicrobial proteins and peptides rank amongst non-oxidative host defenses.
André M. Cantin, Cristine Ouellet, Alexandre Cloutier, Patrick P. McDonald   +3 more
doaj   +1 more source

The protective role of conjunctival goblet cell mucin sialylation

Nature Communications, 2023
Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.
Moe Matsuzawa, Tomoaki Ando, Saaya Fukase, Meiko Kimura, Yasuharu Kume, Takuma Ide, Kumi Izawa, Ayako Kaitani, Mutsuko Hara, Eri Nakamura, Anna Kamei, Akira Matsuda, Nobuhiro Nakano, Keiko Maeda, Norihiro Tada, Hideoki Ogawa, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura   +19 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

State Functions in Latvia Through an Institutional Prism: The Constitution as a Pedestal

Baltic Journal of Law & Politics
The article offers a conceptual perspective on the relevance of the theory of state organs developed in the 19th century in Germany for contemporary state theory in Latvia.
Šulmane Dace, Muciņš Linards
doaj   +1 more source