Modulation of Conjunctival Goblet Cell Function by Inflammatory Cytokines
Mediators of Inflammation, 2013 Ocular surface inflammation associated with Sjögren’s syndrome is characterized by a loss of secretory function and alteration in numbers of mucin secreting goblet cells.
L. Contreras-Ruiz +4 more
doaj +1 more source
Toll-like receptor 4 damages the intestinal epithelial cells by activating endoplasmic reticulum stress in septic rats [PDF]
PeerJBackground The severity of acute gastrointestinal injury (AGI) is a critical determinant of survival in sepsis. However, there is no specifically interventional management for gastrointestinal dysfunction.
Xue Wu, Jilin Yang, Xin Bao, Yijie Wang
doaj +2 more sources
Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
The EMBO Journal, 2023 Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots +9 more
doaj +1 more source
Intestinal epithelial cell-intrinsic deletion of Setd7 identifies role for developmental pathways in immunity to helminth infection [PDF]
, 2016 The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems.
Antignano, Frann +7 more
core +9 more sources
Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. [PDF]
PLoS ONE, 2013 Intestinal epithelial cells (IECs) regulate the absorption and secretion of anions, such as HCO3(-) or Cl(-). Bestrophin genes represent a newly identified group of calcium-activated Cl(-) channels (CaCCs).
Go Ito +15 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC).
Annika Sünderhauf +16 more
doaj +1 more source
Mucosal immune responses following intestinal nematode infection. [PDF]
, 2014 In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Else KJ +11 more
core +4 more sources
The infection of chicken tracheal epithelial cells with a H6N1 avian influenza virus. [PDF]
PLoS ONE, 2011 Sialic acids (SAs) linked to galactose (Gal) in α2,3- and α2,6-configurations are the receptors for avian and human influenza viruses, respectively. We demonstrate that chicken tracheal ciliated cells express α2,3-linked SA, while goblet cells mainly ...
Ching-I Shen +5 more
doaj +1 more source
Aldose reductase inhibition prevents metaplasia of airway epithelial cells. [PDF]
PLoS ONE, 2010 Goblet cell metaplasia that causes mucus hypersecretion and obstruction in the airway lumen could be life threatening in asthma and chronic obstructive pulmonary disease patients.
Umesh C S Yadav +4 more
doaj +1 more source
Colon adenocarcinoma diagnosis in human samples by multicontrast nonlinear optical microscopy of hematoxylin and eosin stained histological sections [PDF]
, 2014 Combined multimodal nonlinear optical (NLO) microscopies were used to detect and quantify morphological changes associated with stroma and epithelial transformation in colon cancer.
Adur, Javier Fernando +7 more
core +1 more source