Results 61 to 70 of about 4,075,359 (296)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Fully Defined GelMA‐Based Matrix Allows Fine Tuning of Tissue‐Relevant Biomechanical and Biochemical Cues for Organoid Culture

Advanced Healthcare Materials, EarlyView.
A fully defined GelMA‐based ECM platform integrates tunable tissue‐relevant stiffness with laminin–entactin biochemical supplementation to support mouse small intestinal organoid growth. Coordinated control of mechanical and biochemical cues promotes robust proliferation, budding morphogenesis, differentiation, and passaging, providing a reproducible ...
Junyi Liu, Su Su Htwe, Lay Poh Tan, Yen Choo   +3 more
wiley   +1 more source

Peningkatan Jumlah Sel Goblet Aktif pada Duodenum Broiler yang Dipapar Heat Stress

, 2011
The purpose of this study was to know the intestinal barrier response by observing number ofactivated goblet cells as mucin producer in the duodenum of broiler exposed by heat stress.
Yunus, Muchammad, Yuliati, M.G.A, Annisa, Mutiara, Arimbi   +3 more
core   +1 more source

Secretagogue Response of Goblet Cells and Columnar Cells in Human Colonic Crypts

, 1999
Crypts of Lieberkühn were isolated from human colon, and differential interference contrast microscopy distinguished goblet and columnar cells.
Halm, Dan R., Halm, Susan T.
core   +2 more sources

Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis

Gut Microbes
Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare, Graham A. D. Blyth, Rita Hannawayya, Karina M. Cirone, Geeta Kilari, Priyoshi Lahiri, Yi Lin Tan, Aydin Ivan Herik, Yongpeng Fu, Hayley Gorman, Björn Petri, Kris Chadee, Eduardo R. Cobo   +12 more
doaj   +1 more source

Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants.

PLoS ONE, 2019
To use human limbal explants as an alternative source for generating conjunctival epithelium and to determine the effect of interleukin-13 (IL-13) on goblet cell number, mucin expression, and stemness. Human limbal explants prepared from 17 corneoscleral
Andrea Stadnikova, Peter Trosan, Pavlina Skalicka, Tor Paaske Utheim, Katerina Jirsova   +4 more
doaj   +1 more source

Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.

PLoS ONE, 2013
The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can ...
Victoria E McGilligan, Meredith S Gregory-Ksander, Dayu Li, Jonathan E Moore, Robin R Hodges, Michael S Gilmore, Tara C B Moore, Darlene A Dartt   +7 more
doaj   +1 more source

Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. [PDF]

PLoS ONE, 2015
Epithelial remodelling in asthma is characterised by goblet cell hyperplasia and mucus hypersecretion for which no therapies exist. Differentiated bronchial air-liquid interface cultures from asthmatic children display high goblet cell numbers. Epidermal
Jeremy C Parker, Isobel Douglas, Jennifer Bell, David Comer, Keith Bailie, Grzegorz Skibinski, Liam G Heaney, Michael D Shields   +7 more
doaj   +1 more source

Is the Intestinal Goblet Cell a Major Immune Cell? [PDF]

Cell Host & Microbe, 2014
Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis.
Johansson, Malin E.V., Hansson, Gunnar C.   +1 more
openaire   +2 more sources

Nanoporous Silica Embedded in Nanoporous Platinum: A Versatile Composite Coating for Implant‐Associated Drug Delivery From Neuronal Electrodes

Advanced Materials Technologies, EarlyView.
Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib, Tim‐Joshua Strauß, Jennifer Harre, Madeleine Goblet, Florian Klodwig‐Kirstein, Jana Schwieger, Michaela Kreienmeyer, Verena Scheper, Athanasia Warnecke, Nina Ehlert, Peter Behrens   +10 more
wiley   +1 more source